Parmacological regulation of erythropoietic precursor pool in experimental neuroses.

Abstract:

:We studied the effect of bone marrow Thy 1,2+ cells on the growth of erythroid colonies and the role of monoamine in the regulation of proliferation and differentiation of erythroid precursor cells in experimental neuroses. Under conditions of conflict situation Thy 1,2+ cells stimulated the growth of erythropoietic precursors (directly and via interaction with adherent cells of the hemopoiesis-inducing environment). Under conditions of paradoxical sleep deprivation the absence of interaction between Thy 1,2+ cells and adherent bone marrow fraction disturbs erythroid colony formation. In experimental neuroses the state of erythropoietic precursors and secretory activity of elements of the hemopoiesis-inducing microenvironment are controlled by monoamines. The regulatory effect of monoamines is realized via adrenergic and erythropoietin-sensitive receptors on erythroid precursors and cells of the hemopoiesis-inducing microenvironment.

journal_name

Bull Exp Biol Med

authors

Skurikhin EG,Provalova NV,Pershina OV,Minakova MY

doi

10.1007/s10517-006-0039-x

subject

Has Abstract

pub_date

2005-11-01 00:00:00

pages

621-6

issue

5

eissn

0007-4888

issn

1573-8221

journal_volume

140

pub_type

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