Abstract:
:We studied the effect of bone marrow Thy 1,2+ cells on the growth of erythroid colonies and the role of monoamine in the regulation of proliferation and differentiation of erythroid precursor cells in experimental neuroses. Under conditions of conflict situation Thy 1,2+ cells stimulated the growth of erythropoietic precursors (directly and via interaction with adherent cells of the hemopoiesis-inducing environment). Under conditions of paradoxical sleep deprivation the absence of interaction between Thy 1,2+ cells and adherent bone marrow fraction disturbs erythroid colony formation. In experimental neuroses the state of erythropoietic precursors and secretory activity of elements of the hemopoiesis-inducing microenvironment are controlled by monoamines. The regulatory effect of monoamines is realized via adrenergic and erythropoietin-sensitive receptors on erythroid precursors and cells of the hemopoiesis-inducing microenvironment.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Skurikhin EG,Provalova NV,Pershina OV,Minakova MYdoi
10.1007/s10517-006-0039-xsubject
Has Abstractpub_date
2005-11-01 00:00:00pages
621-6issue
5eissn
0007-4888issn
1573-8221journal_volume
140pub_type
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