Abstract：
:Changes in cerebral neurogenesis provoked by ischemia and the effect of fluoxetine on this process were studied using a three-vessel occlusion model of global transient cerebral ischemia. The global transient cerebral ischemia was modeled on male Wistar rats by transient occlusion of three major vessels originating from the aortic arch and supplying the brain (brachiocephalic trunk, left subclavian artery, and left common carotid artery). The cells expressing doublecortin (DCX, a marker of young neurons) were counted in the hippocampal dentate gyrus on day 31 after ischemia modeling. It was found that ischemia inhibited neurogenesis in the dentate gyrus in comparison with sham-operated controls (p<0.05), while fluoxetine (20 mg/kg/day) injected over 10 days after surgery restored neurogenesis to the control level (p<0.001).
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Khodanovich MY,Kisel' AA,Chernysheva GA,Smol'yakova VI,Savchenko RR,Plotnikov MBdoi
10.1007/s10517-016-3412-4subject
Has Abstractpub_date
2016-07-01 00:00:00pages
351-4issue
3eissn
0007-4888issn
1573-8221pii
10.1007/s10517-016-3412-4journal_volume
161pub_type
杂志文章abstract：:The effects of two derivatives of 2-aminoadamantane, enantiomers J447H and J579, on the behavior of male and female C57Bl/6J mice were studied using a modified light/dark test. The substances differed by their effects on the behavior of male mice. J579 reduced the number of rearings. J447H in a dose of 1 mg/kg affecte...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-014-2725-4
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abstract：:The myogenic differentiation capacity of prenatal mesenchymal stem cells from the main sites of hemopoiesis (bone marrow, thymus, liver, and spleen) was studied. Myogenesis was observed in all studied cell cultures except splenic mesenchymal stem cells. Differentiating cells from the thymus, bone marrow, and liver wer...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-006-0208-y
更新日期：2006-04-01 00:00:00
abstract：:The intensity of calcium and phosphate accumulation in regenerating bone tissue decreased significantly during the posttraumatic period in 54 male CBA mice with acute hepatic intoxication. The formation of organic components of the bone decreased to a lesser degree. Creatine metabolism in the muscles of damaged segmen...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-010-0996-y
更新日期：2010-10-01 00:00:00
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journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-007-0261-1
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journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-011-1196-0
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journal_title：Bulletin of experimental biology and medicine
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doi：10.1007/s10517-007-0023-0
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doi：10.1007/s10517-018-4268-6
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journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-019-04521-0
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journal_title：Bulletin of experimental biology and medicine
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doi：10.1007/s10517-016-3567-z
更新日期：2016-11-01 00:00:00
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journal_title：Bulletin of experimental biology and medicine
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journal_title：Bulletin of experimental biology and medicine
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journal_title：Bulletin of experimental biology and medicine
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doi：10.1007/s10517-008-0248-6
更新日期：2008-08-01 00:00:00
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journal_title：Bulletin of experimental biology and medicine
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doi：10.1007/s10517-005-0017-8
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doi：10.1007/s10517-007-0251-3
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journal_title：Bulletin of experimental biology and medicine
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更新日期：2015-10-01 00:00:00
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journal_title：Bulletin of experimental biology and medicine
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journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
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journal_title：Bulletin of experimental biology and medicine
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journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-008-0134-2
更新日期：2008-04-01 00:00:00
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journal_title：Bulletin of experimental biology and medicine
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