Abstract:
:The incidence of 5 polymorphisms of N-acetyltransferase-2 gene was evaluated in patients with lung cancer. A803G polymorphism is a factor of lung cancer resistance in tobacco smoking Caucasians in Novosibirsk. Opposite effects of NAT2 gene polymorphisms on the risk of lung cancer are possible.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Nikishina MV,Vavilin VA,Makarova SI,Lyakhovich VVdoi
10.1007/s10517-007-0023-0subject
Has Abstractpub_date
2007-01-01 00:00:00pages
83-6issue
1eissn
0007-4888issn
1573-8221journal_volume
143pub_type
杂志文章abstract::The dependence of daily vitamin excretion with breast milk on dietary vitamin content and blood vitamin level was studied in nursing women. Breast mils vitamins were assayed in women supplied with vitamins. We identified the criteria for adequate vitamin supply in nursing women over the 1st month after labor (vitamins...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-006-0161-9
更新日期:2006-03-01 00:00:00
abstract::Forty patients with severe asthenia were subjected to clinical, neurological, psychometric, and neurophysiologic examination before and after Enerion therapy. Psychoneurophysiological assessment with cognitive evoked potentials P300 and psychometric tests revealed serious impairment of cognitive functions in patients ...
journal_title:Bulletin of experimental biology and medicine
pub_type: 临床试验,杂志文章
doi:10.1023/b:bebm.0000017083.58029.ca
更新日期:2003-11-01 00:00:00
abstract::Clinical and laboratory studies were carried out in 38 pregnant women with antiphospholipid syndrome. Increased functional activity of platelets and decreased protein-producing function of the placenta were observed starting from the early terms of gestation. These disorders were followed by the development of hyperco...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1023/a:1021928903012
更新日期:2002-10-01 00:00:00
abstract::Experiments on rats showed that high-intensity light exposure (6000 lux, 6 h) caused focal injuries in the retina. The most sensitive structures were neurosensory cells, pigmented epithelium, radial gliocytes, and choroid capillaries. Injection of ascovertin led to disappearance of foci of injuries, limited blood supp...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-006-0029-z
更新日期:2005-11-01 00:00:00
abstract::Stimulation of lymph circulation and microcirculation and increase in contractile activity of the wall and cusps of valves in lymphatic microvessels are the mechanisms for a therapeutic effect of dimephosphon. These changes improve resorption and transport of tissue and cell metabolites from the interstitial space. ...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-005-0377-0
更新日期:2005-06-01 00:00:00
abstract::Glutathione S-transferase activity increased in rats with acute pancreatitis: 2.2 times on day 2, 2-fold on day 4, and 1.5 times on day 10. Inducers of microsomal enzymes aroclor 1254 and phenobarbital notably inhibited glutathione S-transferase activity in animals with experimental pancreatitis on days 2-4 of the dis...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/BF02439801
更新日期:2000-05-01 00:00:00
abstract::Acute experiments on anesthetized rabbits were performed to compare dilator responses of the carotid arteries in a wide range of blood flow rates. In males, the reactivity of vessels to changes in blood flow rate was higher than in females. Thirty percent of the revealed sex differences are due to various blood viscos...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/BF02439791
更新日期:2000-05-01 00:00:00
abstract::The third author's name should read: V. V. Matchkov. ...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章,已发布勘误
doi:10.1007/s10517-019-04487-z
更新日期:2019-05-01 00:00:00
abstract::Chinese hamster cells in culture were blocked in prometaphase by the addition of chloral hydrate. After 2 h the chloral hydrate was removed and the ultrastructural changes in the kinetochore studied during recovery of mitosis. The kinetochore in the blocked cells is a disc measuring 300-350 nm in diameter and 30-35 nm...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/BF00799327
更新日期:1975-01-01 00:00:00
abstract::Potential created by electrogenic ionic pumps under conditions of maximum activation in a warm standard ionic medium with K(+) after preincubation in cold potassium-free solution has two components: a higher ouabaine-insensitive "stationary" component, and a lower "regulatory" component sensitive to ouabaine, furosemi...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-006-0461-0
更新日期:2006-12-01 00:00:00
abstract::Fucoidans isolated from Fucus evanescens and Laminaria cichorioides kelp can inhibit thrombin and factor Xa of the blood coagulation system. In rats, intravenous injection of fucoidans dose-dependently increased anticoagulant activity of the plasma. Fucoidans can form complexes with protamine sulfate. The observed qua...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-006-0426-3
更新日期:2006-11-01 00:00:00
abstract::Initiation of apoptosis by chemotherapeutic drugs is one of the most effective approaches to the treatment of cancers. Caspases, the main enzymes of apoptosis, undergo activation to initiate cell death. Activation of initiator caspases requires their binding to special protein complexes. For elucidation of the mechani...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-019-04663-1
更新日期:2019-11-01 00:00:00
abstract::Monoamine metabolism in the hypothalamus and striatum of BALB/c and C57Bl/6 mice (intact and stressed in the open field test) was studied using single- and multidimensional statistical methods. It is suggested that the revealed difference in neurotransmitter metabolism is associated with genetically controlled behavio...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/BF02439811
更新日期:2000-05-01 00:00:00
abstract::Adequate circulation in the transplanted autologous deferent duct can be restored by anastomosing the testicular artery and vein in the transplanted organ with the inferior epigastric vessels on the donor side of the intervention. An obligatory condition to preparation of the graft to transplantation is the presence o...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-007-0384-4
更新日期:2007-10-01 00:00:00
abstract::We studied the role of DNA methylation in the mechanisms of amnesia in edible snails, which was induced by impairment of conditioned food aversion memory reconsolidation with NMDA glutamate receptor antagonist. The effects of DNA methyltransferase inhibitors were shown to depend on the stage of amnesia. At the early s...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-014-2367-6
更新日期:2014-02-01 00:00:00
abstract::Characteristics of distribution of cholinergic and adrenoceptor structures along the sinoatrial node artery in rat heart were evaluated by autoradiography on semithin sections by determining the density of (3)H-dihydroalprenolol and (3)H-quinuclidinyl benzilate binding sites. The relative density of binding sites for ...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-005-0420-1
更新日期:2005-07-01 00:00:00
abstract::Levosimendan is effective in the therapy of chronic heart failure in both mature and old rats, but the duration of its therapeutic effect differs in these age groups. In 15 days after treatment, the myocardium in old rats maintained augmented functionality, whereas in old animals, functional potencies returned to the ...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-020-04815-8
更新日期:2020-05-01 00:00:00
abstract::We performed morphofunctional analysis of cultured rabbit buccal epithelial cells in the primary culture, during passaging, and upon interaction with collagen substrates. Three different morphological types were identified. It was demonstrated that precursors of rabbit buccal epithelium were characterized by high prol...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-015-2915-8
更新日期:2015-05-01 00:00:00
abstract::No appreciable disorders of cellular immunity were detected in patients with glandular cystic endometrial hyperplasia. Atypical endometrial hyperplasia was associated with quantitative changes in T lymphocytes and their subpopulations, decreased level of lymphocytes carrying activation antigens, and increased count of...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1023/a:1023410332246
更新日期:2003-01-01 00:00:00
abstract::Functional activity of the thyroid gland is reduced in Wistar rats with acute experimental endotoxicosis developing in response to sublethal dose of LPS and paralleled by polarization of the immune response by the Th-1 type. This decrease does not depend on the level of thyrotropic hormone and correlates with the prod...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-009-0603-2
更新日期:2009-06-01 00:00:00
abstract::We studied the effect of carbon monoxide (60-, 75-, and 90-min exposure) on the expression of antiapoptotic proteins (survivin and Bcl-2) in human blood lymphocytes in the presence of recombinant IL-2 in an apoptosis-inducing dose (0.1 ng/ml). Incubation of cells in atmosphere with carbon monoxide in the presence of r...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-017-3616-2
更新日期:2017-01-01 00:00:00
abstract::We studied the formation and cytophysiological characteristics of polynuclear macrophages in primary cultures of peritoneal cells from C57Bl/6 mice. Production of reactive oxygen species and phagocytic activity in polynuclear macrophages were higher than in mononuclear macrophages. The formation of polynuclear macroph...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-009-0405-6
更新日期:2008-12-01 00:00:00
abstract::We revealed a significant positive correlation between the concentrations of tissue VEGF and its receptor VEGFR2 in the primary tumor. The degree and direction of changes in the content of VEGF and VEGFR2 in cytosols of tumors from patients with locally spread breast cancer during the preoperation therapy depended on ...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-008-0061-2
更新日期:2008-02-01 00:00:00
abstract::We developed a multiplexed DNA microarray-based assay allowing identification of 12 causative agents of reproductive tract infections with the simultaneous detection of 47 genetic determinants of resistance to antimicrobial substances. The microarray was tested on 93 isolates of Neisseria gonorrhoeae, 32 isolates of T...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-017-3925-5
更新日期:2017-11-01 00:00:00
abstract::We studied daily dynamics of proliferative activity of embryonic fibroblast-like cells in culture during the logarithmic growth phase. Daily increase in cell count in the culture showed a 4-day rhythm that persisted over 3 weeks of culturing. In cultures from different animals, the phase of this rhythm was synchronous...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-020-04962-y
更新日期:2020-09-01 00:00:00
abstract::Kinetics of DNA synthesis in mitotic cycle of in mouse corneal epithelial cells after γ-irradiation in different S phase points was studied by the method of autoradiography. Normally, S phase of corneal epithelial cells consists of two phases (S1 and S2) separated by an interval without DNA synthesis. Each phase, in t...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-014-2715-6
更新日期:2014-11-01 00:00:00
abstract::We studied the effect of experimental liver injury of various origins (toxic, autoimmune, alcoholic, and mesenchymal) in the females on motility of spermatozoa in the offspring. The number of infertile (jerking and immotile) spermatozoa increased, whereas the number of fertile spermatozoa (progressive motile and slow ...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-014-2683-x
更新日期:2014-11-01 00:00:00
abstract::Daily (for 3 days) 1-hour immobilizations were followed by an increase in protein oxidative modification and leukocyte infiltration in the liver, and a decrease in monoamine oxidase B activity. Receptor antagonist of glucocorticoids RU38486 limited the stress-induced increase in protein carbonylation and decrease in m...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-013-2269-z
更新日期:2013-11-01 00:00:00
abstract::MEK, PI3, p38, tyrosine, and mTOR kinases are not involved in the regulation of heart resistance to the arrhythmogenic action of short-term ischemia/reperfusion in non-adapted rats. ...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-015-2848-2
更新日期:2015-04-01 00:00:00
abstract::In vivo cytogenetic effects of cyclophosphamide was simultaneously evaluated in 7 mouse organs. Cyclophosphamide produced most pronounced changes in the urinary bladder and bone marrow, the main target organs for this carcinogen. Mutagenic effects of the preparation were also detected in the lungs, large intestine, an...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1023/a:1017916622451
更新日期:2001-04-01 00:00:00