Effects of cytotoxins on intracellular na/K balance in mouse embryonic cell.

Abstract:

:Cytoplasmic Na/K imbalance induced by cytotoxic substances (ethylene glycol and cytochalasin B) was studied. Incubation in Dulbecco's medium with these cytotoxins caused changes in K and Na concentrations in the mouse two-cell embryo blastomer. The effects of both substances resulted in a drop of Na content in the embryonic cell. Washing from cytochalasin B restored the initial Na/K balance in the cytoplasm. Possible adaptive mechanisms involved in the regulation of intracellular ionic homeostasis are discussed.

journal_name

Bull Exp Biol Med

authors

Pogorelov AG,Goldshtein DV,Pogorelova VN

doi

10.1007/s10517-008-0134-2

subject

Has Abstract

pub_date

2008-04-01 00:00:00

pages

531-4

issue

4

eissn

0007-4888

issn

1573-8221

pii

doi

journal_volume

145

pub_type

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