Combined exposure to electrochemical lysis and photodynamic therapy.

abstract：:We studied the effect of melatonin (10 mg/kg intraperitoneally) on behavioral indexes reflecting changes in nociceptive sensitivity of rats in response to thermal stimulation in the hot plate test. Administration of melatonin to animals suppressed the perceptual component of nociception, which was manifested in an inc...

journal_title：Bulletin of experimental biology and medicine

authors： Zhuravlev BV,Murtazina EP,Pertsov SS

更新日期：2015-12-01 00:00:00

abstract：:Taftsin, an endogenous peptide immunostimulator, exhibits also high antiulcer activity. In a dose of 0.6 micromol/kg Taftsin decreases the area of ulcerative lesions in albino rats on various models of ulceration. ...

journal_title：Bulletin of experimental biology and medicine

authors： Pavlov TS,Samonina GE

更新日期：2004-08-01 00:00:00

abstract：:Comparative investigation of effects of antioxidant agents histochrom and emoxypin on biophysical characteristics of isolated neurons from shell Lymnaea stagnalis under normal conditions and during oxidative stress was performed. Differently directed effects of these compounds on resting potential and transmembrane io...

journal_title：Bulletin of experimental biology and medicine

authors： Mischenko NP,Fedoreev SA,Zapara TA,Ratushnyak AS

更新日期：2009-02-01 00:00:00

abstract：:We studied processes of proliferation and differentiation of hemopoietic precursor cells in mice treated with granulocyte CSF under conditions of cytostatic myelodepression. It was found that the hemostimulating effect of original granulocyte CSF preparation consists in accelerated maturation of hemopoietic precursors...

journal_title：Bulletin of experimental biology and medicine

authors： Goldberg ED,Dygai AM,Zhdanov VV,Guryantseva LA,Udut EV,Popova NO,Simanina EV,Khrichkova TY

更新日期：2005-01-01 00:00:00

abstract：:We studied the influence of the characteristics of oxide porous coatings on osteogenesis and integration of new bone tissue and titanium implant surface in the ectopic osteogenesis test. Implants with coating with pore size 2-20 μ exhibit better osteogenic and osteoconductive characteristics than implants with homogen...

journal_title：Bulletin of experimental biology and medicine

authors： Nadezhdin SV,Zubareva EV,Burda YE,Kolobov YR,Ivanov MB,Khramov GV,Afanas'ev AY

更新日期：2017-04-01 00:00:00

abstract：:We studied the effect of Herceptin therapy on the population composition of lymphocytes and percentage of CD4+CD25+ cells (regulatory T cells) in breast cancer patients. Herceptin treatment decreased the number of "professional" T suppressors (CD4+CD25+ cells and regulatory T cells) in the peripheral blood. ...

journal_title：Bulletin of experimental biology and medicine

authors： Slavina EG,Chertkova AI,Zabotina TN,Gan'shina IP,Lichinitser MR

更新日期：2006-03-01 00:00:00

abstract：:We studied in vitro cytostatic effect of doxorubicin on bone marrow cells preincubated with NAD and reduced glutathione. The presence of NAD and glutathione in the medium potentiated membrane toxicity of this antibiotic, but prevented its toxic effects on intracellular pool of pyridine nucleotides during oxidative str...

journal_title：Bulletin of experimental biology and medicine

authors： Egorova AB,Uspenskaya YA,Nefedov VP

更新日期：2001-07-01 00:00:00

abstract：:We studied the effects of dopamine D1/D2 receptor antagonists on the dynamics of acquisition and extinction of active avoidance responses and open field behavior in ovariectomized female rats. Dopamine D1 receptor antagonist SCH-23390 (0.1 mg/kg intraperitoneally) and dopamine D2 receptor antagonist sulpiride (10.0 mg...

journal_title：Bulletin of experimental biology and medicine

authors： Fedotova YO,Sapronov NS

更新日期：2014-03-01 00:00:00

abstract：:Age-associated changes in the concentrations of glucose, insulin, and DHEAS in peripheral blood plasma of female rhesus macaques were studied in intact animals and in response to a standard dose of glucose and insulin. Basal levels of insulin and glucose increased, insulin sensitivity and glucose tolerance decreased, ...

journal_title：Bulletin of experimental biology and medicine

authors： Goncharova ND,Vengerin AA,Oganyan TE,Lapin BA

更新日期：2004-03-01 00:00:00

abstract：:Cytochemical activity of succinate dehydrogenase and lactate dehydrogenase in blood lymphocytes, activity of hydroperoxides, MDA, and blood plasma antioxidants were studied in experimental animals during immobilization stress after preliminary injection of doxazosin. Preliminary adrenergic receptor blockade prevented ...

journal_title：Bulletin of experimental biology and medicine

authors： Vishnevskii EL,Vishnevskii AE,Shabel'nikova EI,Safronova ON,Dreval AA,Topchieva GV,Sukhorukov VS

更新日期：2004-11-01 00:00:00

abstract：:Behavioral responses of 90-day-old male offspring from female Wistar rats exposed to restraint stress during the last week of pregnancy were studied in the formalin test. Specific biphasic behavioral response characterized acute (phase 1) and persistent tonic pain (phase 2). The intensity of nociceptive responses (eva...

journal_title：Bulletin of experimental biology and medicine

authors： Butkevich IP

更新日期：2002-02-01 00:00:00

abstract：:Taurine is an important endogenous agonist of glycine receptors (GlyR). Using the patchclamp technique, we measured chloride current induced by a short (600 msec) application of taurine (ITau) on isolated rat pyramidal neurons. pH of taurine solution in the applicator pipette was neutral (7.4) or acidic (7.0-5.0). App...

journal_title：Bulletin of experimental biology and medicine

authors： Solntseva EI,Bukanova YV,Kondratenko RV,Skrebitsky VG

更新日期：2019-06-01 00:00:00

abstract：:We studied secretory activity of adrenal zona fasciculata cells in pubertal rats exposed to low doses of endocrine disrupter DDT during prenatal and postnatal periods and only during postnatal period. In exposed animals, circulatory disturbances leading to degeneration and necrosis of cells as well as regeneration foc...

journal_title：Bulletin of experimental biology and medicine

authors： Yaglova NV,Tsomartova DA,Obernikhin SS,Nazimova SV,Yaglov VV

更新日期：2018-12-01 00:00:00

abstract：:We studied properties of cloned BACE mRNA (beta-site of the enzyme cleaving amyloid precursor protein) and evaluated the possibility of using this clone for identification and/or prediction of neurodegenerative disorders associated with cholinergic deficiency. Wistar rats subjected to immunohistochemical destruction o...

journal_title：Bulletin of experimental biology and medicine

authors： Lushchekina EA,Bigl M,Apelt J,Lange-Dohna C,Rossner S,Schliebs R

更新日期：2002-09-01 00:00:00

abstract：:We studied the effects of SNK-411, a new 5-pyrimidinol derivative, on serum cytokine profile of C57Bl/6 mice with Lewis lung carcinoma. The compound was injected intraperitoneally in doses of 25 and 50 mg/kg. A significant (by 3.5 times) increase in serum IL-4 content was detected in mice with tumors on day 9 of tumor...

journal_title：Bulletin of experimental biology and medicine

authors： Kuznetsova OS,Tallerova AV,Nikitin SV,Kovalenko LP

更新日期：2016-02-01 00:00:00

abstract：:An integrative systemic model of pharmacological reaction to a phytopreparation was created as a result of conceptual structurization of facts and formalization of causal relations. The use of the new methodological approach to the choice, primary screening, and profound studies of plants for prospective addition ther...

journal_title：Bulletin of experimental biology and medicine

authors： Mitrofanova IY,Yanitskaya AV,Butenko DV

更新日期：2013-09-01 00:00:00

abstract：:The molecular mechanism of atherosclerosis is based on decreased expression of signal molecules connexin (Cx37 and Cx40), vascular endothelial growth factor (VEGF), and proliferative protein Ki-67, which characterize the processes of cell-cell interactions and proliferation of vascular endotheliocytes. Lys-Glu-Trp pep...

journal_title：Bulletin of experimental biology and medicine

authors： Malinin VV,Durnova AO,Polyakova VO,Kvetnoi IM

更新日期：2014-07-01 00:00:00

abstract：:The morphology of neural and glial cells in different cerebral areas and in various experimental models was quantitatively studied by methods of computer morphometry combined with video image analysis systems. The following parameters were obtained: density of neurons and glial cells per 1 mm(2), number of satellite p...

journal_title：Bulletin of experimental biology and medicine

authors： Khudoerkov RM,Voronkov DN

更新日期：2010-07-01 00:00:00

abstract：:Glycine stabilizes energetics of brain mitochondria under conditions of brain hypoxia in vivo modeled by ligation of the common carotid artery in rats. Hypoxia reduced respiratory control in brain cortex mitochondria from 7.7 ± 0.5 to 4.5 ± 0.3. Preliminary oral administration of glycine almost completely prevented th...

journal_title：Bulletin of experimental biology and medicine

authors： Selin AA,Lobysheva NV,Vorontsova ON,Tonshin AA,Yaguzhinsky LS,Nartsissov YR

更新日期：2012-05-01 00:00:00

abstract：:Blood levels of stem cell marker proteins CD34 and osteonectin were studied in male patients with coronary atherosclerosis by direct biomagnetic separation of proteins with magnetic microspheres using the PureProteome Protein A and Protein G Magnetic Beads proteomic technology. High concentration of osteonectin in the...

journal_title：Bulletin of experimental biology and medicine

authors： Ragino YI,Kashtanova EV,Chernjavski AM,Volkov AM,Polonskaya YV,Tsimbal SY,Eremenko NV,Ivanova MV

更新日期：2011-07-01 00:00:00

abstract：:The dose-dependent effect of intranasal administration of antibodies to glutamate on acute generalized epileptic activity was studied in C57Bl/6 mice. It was shown that pretreatment with antibodies in doses of 100, 300, and 500 μg/kg 1 h before titration with convulsant pentylenetetrazole had anticonvulsant effects. T...

journal_title：Bulletin of experimental biology and medicine

authors： Karpova MN,Kuznetsova LV,Vetrile LA,Klishina NJ

更新日期：2013-07-01 00:00:00

abstract：:Comparative analysis of the efficiency of PCR and microbiological methods for deciphering of the etiological structure of non-nosocomial pneumonias demonstrated the diagnostic significance of detecting Streptococcus pneumoniae DNA in the blood, but not sputum. Mechanisms of penetration of S. pneumoniae into the blood ...

journal_title：Bulletin of experimental biology and medicine

authors： Artemova LV,Beskhlebnaya VA,Ezhova LG,Kirillov MY,Kravtsov EG,Dalin MV

更新日期：2003-10-01 00:00:00

abstract：:We studied changes in the blood cytokine profile of rats 3 h, 1 day, and 8 days after acute stress on the model of 24-h immobilization followed by LPS administration (100 μg/kg intraperitoneally). The concentration of proinflammatory cytokines (particularly of IL-1β and TNFα) significantly decreased at the early stage...

journal_title：Bulletin of experimental biology and medicine

authors： Abramova AY,Pertsov SS,Alekseeva IV,Nikenina EV,Kozlov AY,Chekhlov VV,Chukhnina ME

更新日期：2020-04-01 00:00:00

abstract：:The absence of negative effects of anoceptin on the liver tissue and detoxifying function was proven experimentally in vitro and in vivo. It was proven for the first time that comenic acid (anoceptin active substance) in concentrations of 10(-4)-10(-12) does not modulate the growth of liver explants from 10-12-day chi...

journal_title：Bulletin of experimental biology and medicine

authors： Kipenko AV,Penniyaynen VA,Lopatina EV,Tsyrlin VA,Lobov GI,Krylov BV

更新日期：2010-12-01 00:00:00

abstract：:We studied electrophysiological parameters and morphological changes in the adrenal glands and spleen of CBA mice feeding a low-choline diet and/or ethanol-containing diet. The polarization coefficient underwent similar changes in the adrenal glands and spleen, which was associated with different contribution of imped...

journal_title：Bulletin of experimental biology and medicine

authors： Tornuev YV,Nepomnyashchikh LM,Koldysheva EV

更新日期：2005-11-01 00:00:00

abstract：:We studied the effect of carbon monoxide (60-, 75-, and 90-min exposure) on the expression of antiapoptotic proteins (survivin and Bcl-2) in human blood lymphocytes in the presence of recombinant IL-2 in an apoptosis-inducing dose (0.1 ng/ml). Incubation of cells in atmosphere with carbon monoxide in the presence of r...

journal_title：Bulletin of experimental biology and medicine

authors： Artyukhov VG,Tyunina OI

更新日期：2017-01-01 00:00:00

abstract：:The concentrations of proinflammatory cytokines (IL-1beta, IL-6), vascular endothelium growth factor, tumor growth factor-beta, and insulin-like growth factor-1 were measured in the peritoneal fluid of patients with external genital endometriosis and healthy women by enzyme immunoassay. The effect of peritoneal fluid ...

journal_title：Bulletin of experimental biology and medicine

authors： Sokolov DI,Solodovnikova NG,Pavlov OV,Niauri DA,Volkov NN,Sel'kov SA

更新日期：2005-11-01 00:00:00

abstract：:Coagulation and optical (based on chromogenic substrate) methods were employed to examine antithrombin activity of erythrocytes and erythrocyte-derived microvesicles isolated days 7, 14, 21, and 28 on erythrocyte storage. The erythrocyte-derived microvesicles decelerated fibrin clot formation from fibrinogen in the pr...

journal_title：Bulletin of experimental biology and medicine

authors： Levin GY,Sukhareva EG

更新日期：2017-04-01 00:00:00

abstract：:We studied the effect of continuous vibration and treatment with licorice root (Glycyrrhiza glabra L.) on peripheral blood red cells in rabbits. Active substances of licorice root accelerated metabolism in cells of the bone marrow erythroid stem, enhanced compensatory reserve of the organism, and increased animal's re...

journal_title：Bulletin of experimental biology and medicine

authors： Adamyan TI,Gevorkyan ES,Minasyan SM,Oganesyan KR,Kirakosyan KA

更新日期：2005-08-01 00:00:00

abstract：:In acute experiments on cats neural inotropic and lusitropic reactions of the heart to enhancement of pre- and afterload were assessed by changes in contractility and relaxation indices, which were preliminary chosen for their maximum specificity and sensitivity. The control cardiac responses to increased pre- and aft...

journal_title：Bulletin of experimental biology and medicine

authors： Alipov NN,Sokolov AV,Trubetskaya LV,Kuznetsova TE

更新日期：2003-04-01 00:00:00