Adaptation to hypoxia prevents disturbances in cerebral blood flow during neurodegenerative process.

abstract：:The relative content of myocyte-active factors and endogenous muscarinic receptor blocker in the blood increased, while the concentration of endogenous beta-adrenoceptor sensitizer decreased in coronary patients with a history of acute myocardial infarction. Physical training produced a therapeutic effect, normalized ...

journal_title：Bulletin of experimental biology and medicine

authors： Tsirkin VI,Nozdrachev AD,Sizova EN,Mal'chikova SV,Gulyaeva SF

更新日期：2003-07-01 00:00:00

abstract：:The paper analyzes theoretical models of the adaptive modes of generation and stability of human heart as a nonlinear point source. The analysis encompasses only ECG time-domain dynamics. To solve the general problem of the study of the adaptive changes of the cardiosignal under the action of external periodic force a...

journal_title：Bulletin of experimental biology and medicine

authors： Pipin VV,Ragulskaya MV,Chibisov SM

更新日期：2010-10-01 00:00:00

abstract：:Study was performed by counting cells with chromosomal aberrations in C57Bl/6 mice. Bark dry extract was given perorally in doses of 50, 150, 450, and 1500 mg/kg. Mutagens dioxidine and cyclophosphamide were injected intraperitoneally in doses of 200 and 20 mg/kg, respectively. Bark dry extract in doses of 150 and 150...

journal_title：Bulletin of experimental biology and medicine

authors： Zhanataev AK,Presnova GA,Chistyakov AN,Durnev AD

更新日期：2004-11-01 00:00:00

abstract：:We propose a noninvasive method of in vivo examination the hemostasis system based on speckle pattern analysis of coherent light scattering from the skin. We compared the results of measuring basic blood coagulation parameters by conventional invasive and noninvasive methods. A strict correlation was found between the...

journal_title：Bulletin of experimental biology and medicine

authors： Kuznik BI,Fine IW,Kaminsky AV

更新日期：2011-09-01 00:00:00

abstract：:We studied morphological changes in the myocardium during experimental myocardial infarction in rats with different resistance to hypoxia. Microscopic examination showed that morphological changes in the ischemic zone and adjacent tissues are different in rats with high and low resistance to acute ischemia. In highly ...

journal_title：Bulletin of experimental biology and medicine

authors： Karimov KY,Saidov AB,Israilov RI

更新日期：2001-10-01 00:00:00

abstract：:A variety of clinical manifestations of vertebrobasilar insufficiency in virtually the same anatomical disorders of the vertebral arteries indicates the multilevel regulation of the cerebral bloodflow aimed at its stabilization and maintenance. The main arteries of the head and peripheral arteries were studied by Dopp...

journal_title：Bulletin of experimental biology and medicine

authors： Vokina TA,Tkachenko SB,Beresten NF,Tvalavadze VV

更新日期：2008-10-01 00:00:00

abstract：:Effects of pentobarbital on spectral characteristics and phase ratios of wave oscillations of the cardiac contraction period (RR interval) and time of atrioventricular conduction (AV interval) were studied in experiments of cats. Pentobarbital moderately reduced the mean values of both intervals and significantly redu...

journal_title：Bulletin of experimental biology and medicine

authors： Alipov NN,Sergeeva OV,Smirnov VM,Kuznetsova TE,Bobrova NA

更新日期：2006-03-01 00:00:00

abstract：:The degree of oxygen consumption in rats was determined after intraperitoneal injection of morphine in a single dose of 5 mg/kg. Some animals were injected with morphine and perorally received morphine or antibodies to mu-opiate receptors in ultralow doses obtained by the technology of potentiation. Potentiated substa...

journal_title：Bulletin of experimental biology and medicine

authors： Pavlov IF,Epstein OI

更新日期：2003-01-01 00:00:00

abstract：:We studied the effects of selective delta-opiate receptor agonists and antagonists on the phosphoinositide pathway in lymphocytes from healthy donors and patients with diabetes mellitus. The test compounds probably play a role in changes in the sensitivity to pharmacological substances binding to delta-opiate receptor...

journal_title：Bulletin of experimental biology and medicine

authors： Agadjanov MI,Vartanian GS,Tadevosyan YV,Batikyan TB,Agadjanova EM

更新日期：2004-02-01 00:00:00

abstract：:Tenoten is a new anxiolytic and antidepressant based on antibodies to brain-specific protein S-100B. Experimental studies demonstrated the effect of tenoten on mechanisms of neuronal plasticity and manifestations of higher nervous activity. Tenoten is clinically comparable with amitryptiline, sertraline, and phenazepa...

journal_title：Bulletin of experimental biology and medicine

authors： Duma SA,Shishkin SV

更新日期：2009-08-01 00:00:00

abstract：:Spontaneous and stimulated reaction of lymphocyte proliferation and blood levels of CD25- and CD120-expressing lymphocytes were studied in patients with autoimmune thyroiditis and diffuse toxic goiter. Activation of CD25- and CD120-presenting function of blood lymphocytes was revealed. The findings indicate that the c...

journal_title：Bulletin of experimental biology and medicine

authors： Urazova OI,Kravets EB,Nedosekova YV,Rogaleva AV,Kuznecova VN,Rumpel OA

更新日期：2008-09-01 00:00:00

abstract：:We studied properties of cloned BACE mRNA (beta-site of the enzyme cleaving amyloid precursor protein) and evaluated the possibility of using this clone for identification and/or prediction of neurodegenerative disorders associated with cholinergic deficiency. Wistar rats subjected to immunohistochemical destruction o...

journal_title：Bulletin of experimental biology and medicine

authors： Lushchekina EA,Bigl M,Apelt J,Lange-Dohna C,Rossner S,Schliebs R

更新日期：2002-09-01 00:00:00

abstract：:We studied the effects of lithium carbonate on the cell cycle, apoptosis, and autophagy in hepatocellular carcinoma-29 cells (HCC-29) in vitro. Flow cytofluorometry analysis revealed accumulation of G2/M-phase HCC-29 cells and increase in the number of apoptotic cells in 48 h after administration of 5 mM lithium carbo...

journal_title：Bulletin of experimental biology and medicine

authors： Taskaeva YS,Bgatova NP,Dossymbekova RS,Solovieva AO,Miroshnichenko SM,Sharipov KO,Tungushbaeva ZB

更新日期：2020-12-01 00:00:00

abstract：:Intensive exercise triggers the cascade processes of body adaptation, including modulation of splisosome functioning, and can lead to modification of its activity and choice of alternative exons. We studied the effect of exercise of the maximum aerobic power on activation of transcription of genes involved in the spli...

journal_title：Bulletin of experimental biology and medicine

authors： Tonevitsky EA,Trushkin EV,Shkurnikov MU,Akimov EB,Sakharov DA

更新日期：2009-06-01 00:00:00

abstract：:Single intramuscular injection of selective of NMDA receptor blocker memantine in the maximum dose of 20 mg/kg prevented the development of acute generalized tonic-clonic kainate seizures in 60% rats, but did not alleviate clonic kainate seizures and prevented chronic kainate lethality in only 30% rats. Intramuscular ...

journal_title：Bulletin of experimental biology and medicine

authors： Serdyuk SE,Gmiro VE,Veselkina OS

更新日期：2014-05-01 00:00:00

abstract：:We studied the effect of sodium hydrosulfite (NaHS), a donor of hydrogen sulfide (H2S), on spontaneous contractive activity of isolated preparations of rat stomach and jejunum under isometric conditions. NaHS in concentrations of 10-200 μM reduced the amplitude, tonic tension, and frequency of contractions of the prep...

journal_title：Bulletin of experimental biology and medicine

authors： Shafigullin MY,Zefirov RA,Sabirullina GI,Zefirov AL,Sitdikova GF

更新日期：2014-07-01 00:00:00

abstract：:We studied the effect of terahertz radiation at NO frequencies 150.176-150.664 GHz on gaseous and electrolyte composition of the blood in albino rats during stress. Partial or complete recovery of the studied parameters of blood gases and electrolytes in stressed animals was observed after 15- and 30-min terahertz irr...

journal_title：Bulletin of experimental biology and medicine

authors： Kirichuk VF,Tsymbal AA

更新日期：2010-12-01 00:00:00

abstract：:Nanocrystalline particles of chitin in the form of hydrosol in a concentration of 0.63 mg/ml have no effect on aggregation of human platelets and clotting time of platelet-poor plasma in coagulation tests. ADP-induced aggregation of human platelets was inhibited by these nanoparticles in concentrations of 0.63 and 1.0...

journal_title：Bulletin of experimental biology and medicine

authors： Drozd NN,Torlopov MA,Udoratina EV,Logvinova YS

更新日期：2018-04-01 00:00:00

abstract：:We studied sterility and toxicity of vaccine LS1 containing aberrant gangliosides isolated from brain bioptates of 48 patients with gliomas of different malignancy and covalently bound to keyhole limpet hemocyanin. The vaccine was safe. This preparation produced no side effects in experimental animals. Our findings su...

journal_title：Bulletin of experimental biology and medicine

authors： Lombardi V,Shnaar R,Minev B,Misasi R,Gitstsi Kh,Sorice M,Troncone A

更新日期：2002-10-01 00:00:00

abstract：:The tissue engineering construction was developed from human bone marrow multipotent stromal cells and 3D porous foamed-ceramic carriers of a zirconium oxide-aluminum oxide system. The carriers had no cytotoxic activity and were potent in maintaining the cell adhesion and proliferation. We developed the method for ino...

journal_title：Bulletin of experimental biology and medicine

authors： Bukharova TB,Fatkhudinov TKh,Tsedik LV,Ilyushchenko AF,Goldshtein DV

更新日期：2009-01-01 00:00:00

abstract：:Delayed consequences of acute hypoxia were studied in 60-day-old rat pups. The animals were exposed to acute hypobaric hypoxia on day 10 of embryogenesis. The offspring of intact females served as the control. Reactivity of mesenteric lymphatic vessels to norepinephrine was studied by vital microscopy. The frequency a...

journal_title：Bulletin of experimental biology and medicine

authors： Sanzhieva LTs,Graf AS,Maslova MV,Lelekova TV,Sokolova NA

更新日期：2004-07-01 00:00:00

abstract：:The animals were adapted to intermittent hypoxic hypoxia in a flow pressure chamber for 3 days. Each one-day training session consisted of 4 elevations to an altitude of 6000 m for 20 min (15 m/sec, 20-min intervals between assents). Trekrezan (25 mg/kg intraperitoneally) was injected immediately after the end of dail...

journal_title：Bulletin of experimental biology and medicine

authors： Zarubina IV

更新日期：2008-01-01 00:00:00

abstract：:We compared the efficiency of different stereoisomers of organic magnesium salts (Mg DL-, Mg D-, and Mg L-aspartate and Mg L- and Mg DL-glutamate) after oral administration under conditions of furosemide-induced magnesium deficiency. The time to complete compensation of erythrocyte magnesium level was 5 days for Mg L-...

journal_title：Bulletin of experimental biology and medicine

authors： Spasov AA,Ozerov AA,Iezhitsa IN,Kharitonova MV,Kravchenko MS,Zheltova AA

更新日期：2011-07-01 00:00:00

abstract：:C57Bl/6 mice were intranasally infected with influenza virus A/H5N1 A/goose/Krasnoozerskoye/627/05. The mortality rate of animals reached 70% on day 14 of the disease. The lungs of animals were characterized by necroses, destruction of vessels, hemorrhagic and thrombotic complications, edematous syndrome, and early fi...

journal_title：Bulletin of experimental biology and medicine

authors： Kovner AV,Anikina AG,Potapova OV,Sharkova TV,Cherdanceva LA,Shkurupy VA,Shestopalov AM

更新日期：2012-06-01 00:00:00

abstract：:Sulfamide-resistant (SulR) natural strains of enterobacteria (11.9% of a total of 797 cultures, isolated with enteric microflora of honeybee gut, bee-fermented pollen, and plant issues) were tested for class 1 antibiotic resistance integrons (MRI). Only 5.3% of SulR strains were MRI-positive. Mutability of weak (wild ...

journal_title：Bulletin of experimental biology and medicine

authors： Solomenny AP,Lyapunov YE,Kuzyaev RZ

更新日期：2011-09-01 00:00:00

abstract：:The prooxidant-antioxidant balance in rats with oxidative stress was studied during correction of the L-arginine-NO system. Oxidative stress was induced by intravenous injection of E. coli lipopolysaccharide. Under conditions of oxidative stress the prooxidant-antioxidant imbalance was least pronounced during selectiv...

journal_title：Bulletin of experimental biology and medicine

authors： Glebov AN,Zinchuk VV

更新日期：2006-04-01 00:00:00

abstract：:The relationships between open field behavior, initial nociceptive thresholds, and immunoreactivity assessed according to the development of hyperthermia triggered by LPS pyrogenal were examined in Wistar rats. Behaviorally active animals demonstrated higher nociceptive thresholds and greater immunoreactivity in compa...

journal_title：Bulletin of experimental biology and medicine

authors： Abramova AY,Abramov YB

更新日期：2011-12-01 00:00:00

abstract：:Fucoidans isolated from Fucus evanescens and Laminaria cichorioides kelp can inhibit thrombin and factor Xa of the blood coagulation system. In rats, intravenous injection of fucoidans dose-dependently increased anticoagulant activity of the plasma. Fucoidans can form complexes with protamine sulfate. The observed qua...

journal_title：Bulletin of experimental biology and medicine

authors： Drozd NN,Tolstenkov AS,Makarov VA,Kuznetsova TA,Besednova NN,Shevchenko NM,Zvyagintseva TN

更新日期：2006-11-01 00:00:00

abstract：:The effect of panavir on Parkinson's syndrome induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine was studied in C57Bl/6 mice and outbred albino rats. Two injections of panavir significantly reduced the severity of oligokinesia and autonomic manifestations of experimentally induced Parkinson's syndrome. ...

journal_title：Bulletin of experimental biology and medicine

authors： Kalinina TS,Nerobkova LN,Voronina TA,Stovbun SV,Litvin AA,Sergienko VI

更新日期：2005-07-01 00:00:00

abstract：:More than 70% malignant mammary tumors contain steroid hormone receptors; this suggests the possibility of hormone therapy in the majority of patients with breast cancer (BC). The main cause of inefficiency of hormone therapy in BC is hormone resistance (tumor resistance to hormonal cytostatics). Here we discuss the m...

journal_title：Bulletin of experimental biology and medicine

authors： Scherbakov AM,Krasil'nikov MA,Kushlinskii NE

更新日期：2013-07-01 00:00:00