Prooxidant-antioxidant state of the organism during oxidative stress and correction of the L-arginine-NO system.

Abstract:

:The prooxidant-antioxidant balance in rats with oxidative stress was studied during correction of the L-arginine-NO system. Oxidative stress was induced by intravenous injection of E. coli lipopolysaccharide. Under conditions of oxidative stress the prooxidant-antioxidant imbalance was least pronounced during selective correction of the L-arginine-NO system. L-Arginine and nonselective NO synthase inhibitor had little protective effect.

journal_name

Bull Exp Biol Med

authors

Glebov AN,Zinchuk VV

doi

10.1007/s10517-006-0178-0

subject

Has Abstract

pub_date

2006-04-01 00:00:00

pages

387-9

issue

4

eissn

0007-4888

issn

1573-8221

journal_volume

141

pub_type

杂志文章
  • Count and phagocytic activity of leukocytes in rats with experimental depressive syndrome caused by systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

    abstract::Leukocyte count decreased, relative content of neutrophils and monocytes increased, and their phagocytic activity was suppressed in rats with 1-methyl-4-phenyl-1,2,3,4-tetrahydropyridine-induced depressive syndrome at the stage of acute behavioral depression. The severity of behavioral depression inversely correlated ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:

    authors: Krupina NA,Davydova TV,Fomina VG,Kryzhanovskii GN,Orlova IN

    更新日期:2000-11-01 00:00:00

  • Tenoten in the therapy of patients with moderate cognitive impairment.

    abstract::Tenoten is a new anxiolytic and antidepressant based on antibodies to brain-specific protein S-100B. Experimental studies demonstrated the effect of tenoten on mechanisms of neuronal plasticity and manifestations of higher nervous activity. Tenoten is clinically comparable with amitryptiline, sertraline, and phenazepa...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 临床试验,杂志文章

    doi:10.1007/s10517-009-0679-8

    authors: Duma SA,Shishkin SV

    更新日期:2009-08-01 00:00:00

  • Tissue- and urokinase-type plasminogen activators and type 1 plasminogen activator inhibitor in melanomas and benign skin pigment neoplasms.

    abstract::The content of urokinase- and tissue-type plasminogen activators and plasminogen activator inhibitor PAI-1 in the cytosol of primary and metastatic melanomas and benign skin pigment neoplasms was estimated by enzyme immunoassay. It was shown that local growth and invasion of melanomas are related to suppressed express...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/a:1012532412896

    authors: Gershtein ES,Medvedeva SV,Babkina IV,Kushlinskii NE,Trapeznikov NN

    更新日期:2001-07-01 00:00:00

  • Delayed effects of long-term administration of granulocyte colony-stimulating factor to mice.

    abstract::We studied the effects of chronic administration of granulocyte colony-stimulating factor in nonmobilizing doses to mice. Over 18 months of the study, 55% animals of the treatment group died of unknown cause, blood diseases and tumors were found in 20% mice, and in 5% animals pathological changes were absent. Control ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-008-0166-7

    authors: Nifontova IN,Svinareva DA,Chertkov IL,Drize NI,Savchenko VG

    更新日期:2008-05-01 00:00:00

  • Effect of Liposome-Encapsulated Zoledronic Acid on Microenvironment of Hepatocellular Carcinoma May Depend on the Ratio Between M1 and M2 Polarized Macrophages.

    abstract::We studied the effect of zoledronic acid encapsulated into liposomes (L-ZOL) on tumorassociated macrophages in the stroma of hepatocellular carcinoma xenograft. Liposomes were prepared from 1,2-dipalmitoyl-sn-glycero-3-phosphocholine, 1,2-dipalmitoyl-snglycero-3-phospho-sn-1-glycerol, and 1,2-distearoyl-sn-glycero-3-p...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-020-05006-1

    authors: Wu S,Lin X,Cui X

    更新日期:2020-11-01 00:00:00

  • Correction to: Comparative Analysis of the Expression of Glutathione Peroxidase and Glutathione Reductase Genes in Human Sperm after Cryopreservation.

    abstract::The second author's name should read A. Yu. Romanov. ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章,已发布勘误

    doi:10.1007/s10517-018-4152-4

    authors: Makarova NP,Romanov AY,Dolgushina NV,Parker MM,Krasnyi AM

    更新日期:2018-06-01 00:00:00

  • Isolation of toxins from Buthus occitanus sp. scorpion and their action on excitability of myelinated nerve.

    abstract::A series of short neurotoxins (molecular weight 3500-5000 D) was isolated from Vietnamese scorpion B. occitanus sp. All these toxins blocked generation of action potentials (this effect depended on their molecular weight), but did not change conduction velocity and excitation threshold of the nerve. ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/a:1013659026064

    authors: Hoang NA,Maksimov GV,Berezin BB,Piskarev VE,Yamskov IA

    更新日期:2001-10-01 00:00:00

  • Activity of the Hypothalamic-Pituitary-Adrenal System in Prenatally Stressed Male Rats on the Experimental Model of Post-Traumatic Stress Disorder.

    abstract::Using the experimental model of post-traumatic stress disorder (stress-restress paradigm), we studied the dynamics of activity of the hypothalamic-pituitary-adrenal system (HPAS) in adult male rats, whose mothers were daily subjected to restraint stress on days 15-19 of pregnancy. Prenatally stressed males that were s...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-016-3227-3

    authors: Pivina SG,Rakitskaya VV,Akulova VK,Ordyan NE

    更新日期:2016-03-01 00:00:00

  • Reaction of rat tissues to implantation of lactic acid-based biodegradable polymer.

    abstract::Polylactide degradation processes after its implantation into the subcutaneous fat of rats were studied by microscopy. After implantation polylactide was encapsulated in connective tissue. If a fragment of polylactide had sharp edges, injuring the tissue, a thick capsule formed with pronounced inflammatory infiltratio...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-014-2473-5

    authors: Maiborodin IV,Kuznetsova IV,Beregovoi EA,Shevela AI,Barannik MI,Maiborodina VI,Manaev AA

    更新日期:2014-04-01 00:00:00

  • Role of CD40-dependent signal in induction of recombinase RAG-1 expression in peripheral T cells of patients with autoimmune diabetes mellitus.

    abstract::We studied the mechanisms of induction of recombinase activity in peripheral T cells of patients with autoimmune type 1 diabetes mellitus. It was shown that the presence of CD40 on T cell membrane (not typical of these cells) is crucial for this process: expression of recombinase RAG-1 in diabetic patients was detecte...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-012-1522-1

    authors: Kuklina EM,Gorbunova OL,Smirnova EN

    更新日期:2012-01-01 00:00:00

  • Biocompatibility and Bioresorption of 3D-Printed Polylactide and Polyglycolide Tissue Membranes.

    abstract::We studied biocompatibility and bioresorption of 3D-printed polylactide and polyglycolide tissue membranes. Ultrasound microscopy and histological examination showed that membranes fabricated of a copolymer of lactic and glycolic acids in a mass ratio of 1:9 are bioresorbed and have good biocompatibility with soft tis...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-021-05066-x

    authors: Kim EV,Petronyuk YS,Guseynov NA,Tereshchuk SV,Popov AA,Volkov AV,Gorshenev VN,Olkhov AA,Levin VM,Dymnikov AB,Rodionov VE,Tumanyan GA,Ivashkevich SG,Bonartsev AP,Borozdkin LL

    更新日期:2021-01-01 00:00:00

  • Effect of Selank on Spontaneous Synaptic Activity of Rat Hippocampal CA1 Neurons.

    abstract::Application of anxiolytic drug Selank to hippocampal slices increased the amplitude and discharge rate of spontaneous inhibitory postsynaptic currents in rat hippocampal pyramidal CA1 neurons. In some neurons, Selank-induced up-regulation of spontaneous inhibitory postsynaptic currents was preceded by a transient decr...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-017-3676-3

    authors: Povarov IS,Kondratenko RV,Derevyagin VI,Myasoedov NF,Skrebitsky VG

    更新日期:2017-03-01 00:00:00

  • Effect of Coenzyme Q10 on Expression of UbiAd1 Gene in Rat Model of Local Cerebral Ischemia.

    abstract::The study examined the effect of endogenous lipid-soluble antioxidant coenzyme Q10 on the expression of UbiA gene of prenyltransferase domain-containing protein 1 (UbiAd1) involved in synthesis of vitamin K2 (and probably of coenzyme Q10) on a rat model of ischemic stroke provoked by ligation of the middle cerebral ar...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-018-4101-2

    authors: Povarova OV,Balatsky AV,Gusakov VS,Medvedev OS

    更新日期:2018-05-01 00:00:00

  • Effect of Interchain Disulfide Crosslinking in the Tropomyosin Molecule on Actin-Myosin Interaction in the Atrial Myocardium.

    abstract::Tropomyosin (Tpm) is one of the main regulatory proteins in the myocardium. In some heart pathologies, interchain disulfide crosslinking in the Tpm molecule occurs. In the ventricle, this change in the structural properties of the Tpm molecule affects calcium regulation of the actin-myosin interaction. Using an in vit...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-019-04462-8

    authors: Shchepkin DV,Matyushenko AM,Bershitsky SY,Kopylova GV

    更新日期:2019-05-01 00:00:00

  • Selective Cytotoxicity of Manganese Nanoparticles against Human Glioblastoma Cells.

    abstract::Toxicity of different types of manganese nanoparticles against glioblastoma U-87MG and U-251 cells and normal human cells was studied using MTT test. The selectivity of the toxic effect of nanoparticles was evaluated as the ratio of 50% cytotoxic concentration (СС50) for human embryos fibroblasts (FECh-15) to their СС...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-017-3849-0

    authors: Razumov IA,Zav'yalov EL,Troitskii SY,Romashchenko AV,Petrovskii DV,Kuper KE,Moshkin MP

    更新日期:2017-08-01 00:00:00

  • Effect of glyprolines on homeostasis of gastric mucosa in rats with stress ulcers.

    abstract::Pro-Gly-Pro and its metabolite Gly-Pro effectively prevented the development of erosive and ulcerative lesions of the gastric mucosa in rats under conditions of water-immersion restraint stress by restoring the oxidatant-antioxidant balance in the total fraction of gastric mucosa cells. Pro-Gly was least effective in ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-010-0866-7

    authors: Falalyeyeva TM,Samonina GE,Beregovaya TV,Andreeva LA,Dvorshchenko EV

    更新日期:2010-07-01 00:00:00

  • Comparison of the Effect of Platinum (IV) Complexes on Spheroids and Monolayer Culture of HeLa Cells.

    abstract::We performed a comparative study of the cytotoxicity of cisplatin, JM216 complex, and aminonitroxyl platinum(IV) complexes for HeLa cells grown in monolayer and 3D culture. The growth dynamics of spheroids was studied and optimal conditions for evaluation of cytotoxicity were determined. Spheroids were less sensitive ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-020-04757-1

    authors: Trigub ММ,Filatova NV,Areshidze DА,Sen' VD,Terentiev АА

    更新日期:2020-02-01 00:00:00

  • Models of reactions of human heart as nonlinear dynamic system to cosmic and geophysical factors.

    abstract::The paper analyzes theoretical models of the adaptive modes of generation and stability of human heart as a nonlinear point source. The analysis encompasses only ECG time-domain dynamics. To solve the general problem of the study of the adaptive changes of the cardiosignal under the action of external periodic force a...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-010-0977-1

    authors: Pipin VV,Ragulskaya MV,Chibisov SM

    更新日期:2010-10-01 00:00:00

  • Influence of 5-HT(2) receptor agonist on cardiac pumping function of trained offspring of trained rats.

    abstract::We studied cardiac pumping function in the offspring of rats subjected to swimming exercise and the offspring of untrained rats. The rat pups were adapted for swimming with stepwise increasing load from day 21 to 70 life. At the age of 21 and 70 days, offspring of trained rats showed lower HR and significantly higher ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-012-1704-x

    authors: Valeev AM,Abzalov NI,Abzalov RA,Nigmatullina RR,Abzalov RR,Nikitin AS

    更新日期:2012-07-01 00:00:00

  • Morphological changes in immune and endocrine organs of mice injected with a gonadotropin-releasing hormone analog.

    abstract::Infection of surfagon (gonadotropin-releasing hormone analog) in a dose of 0.1 microg/kg to male CBA mice stimulated lymphocyte migration from splenic B zones, caused moderate thinning of the thymic cortex, thickening of the zona fasciculata of the adrenal cortex with signs of corticocyte activation. After administrat...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-005-0225-2

    authors: Bobyntsev II,Dolzhikov AA,Severyanova LA

    更新日期:2005-01-01 00:00:00

  • Effect of iron ions on functional activity of thrombin.

    abstract::The kinetics of thrombin inhibition by irons ions was studied in the thrombin time test with normal plasma. The kinetic and concentration characteristics for recovery of thrombin activity by desferal were evaluated at various periods of thrombin incubation with iron ions. The thrombin time test showed that incubation ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-010-0814-6

    authors: Azizova OA,Shvachko AG,Aseichev AV

    更新日期:2009-11-01 00:00:00

  • Bacterial markers of periodontal diseases and their practical significance in dentistry.

    abstract::The incidence and prevalence of Actinobacillus actinomycetemcomitans, Porphyronmonas gingivalis, and Tannerella forsythensis in specimens of subgingival dental deposit were evaluated in 495 residents of St. Petersburg aged 6-82 years. The microorganisms were detected by gene-specific PCR of 16S rDNA. In accordance wit...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-007-0374-6

    authors: Chukhlovin AB,Solovyova AM,Matelo SK,Kobiyasova IV,Morosova EB,Hokhlacheva AV,Teplyakov BG,Syssoev KA,Konstantinova VE,Matelo LN,Totolian AA

    更新日期:2007-10-01 00:00:00

  • DMSO-Free Cryopreservation of Human Umbilical Cord Tissue.

    abstract::Human umbilical cord represents a source of multipotent stromal cells of a supreme therapeutic potential. The cells can be isolated from either fresh or cryopreserved umbilical cord tissues. DMSO is a cryoprotectant most commonly used for preservation of umbilical cord tissues; however, cyto- and genotoxicity of this ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-018-4305-5

    authors: Arutyunyan IV,Strokova SО,Makarov АV,Mullabaeva SМ,Elchaninov АV,Lokhonina АV,Abramov АА,Fatkhudinov ТK

    更新日期:2018-11-01 00:00:00

  • Effect of ladasten on the content of cytokine markers of inflammation and behavior of mice with experimental depression-like syndrome.

    abstract::The effects of ladasten and reference product imipramine (10 mg/kg) on the content of cytokines TNF-α, IL-6, IL-10, IL-1α, IL-2, IL-4, IL-5, IL-17, IFN-γ, and GM-CSF and behavior of male C57Bl/6 mice were studied on the model of a depression-like state induced by a single intraperitoneal injection of bacterial LPS in ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-011-1453-2

    authors: Tallerova AV,Kovalenko LP,Durnev AD,Seredenin SB

    更新日期:2011-11-01 00:00:00

  • Inhibition of norepinephrine reuptake and size of myocardial infarction during focal ischemia and after preconditioning.

    abstract::Experiments on rats showed that blockade of norepinephrine reuptake in the early reperfusion period after focal myocardial ischemia aggravates myocardial injury and abolishes the protective effect of ischemic preconditioning. ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-010-1056-3

    authors: Naumenko SE,Latysheva TV,Gilinskii MA

    更新日期:2010-12-01 00:00:00

  • Estimation of Expression of Oral Fluid Biomarkers in the Diagnosis of Pretumor Diseases of Oral Mucosa.

    abstract::Complex clinical, dental, and morphological investigation, and ELISA of levels of MMP-2, 8, 9, and TIMP-1 and 2 in the saliva was performed during primary examination of patients with premalignant lesions of maxillofacial area and practically healthy volunteers. Levels of all study MMP in the saliva significantly diff...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-017-3744-8

    authors: Kochurova EV,Nikolenko VN

    更新日期:2017-05-01 00:00:00

  • Experimental study of hepatoprotective activity of hydroxymethyluracil.

    abstract::Hepatoprotective activity of pyrimidine derivative hydroxymethyluracil was studied on the model of acute paracetamol-induced liver damage in rats. Hydroxymethyluracil was shown to produce a strong hepatoprotective effect. ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-007-0183-y

    authors: Mirsaev TR

    更新日期:2007-05-01 00:00:00

  • Content of steroid hormones in the blood and adrenal glands of mice in the dynamics of BCG- and SiO2-induced granulomatous inflammation.

    abstract::Individual or combined administration of BCG vaccine and silicon dioxide to male mice induced a nonspecific stress response of the adrenal glands and gonads judging from changes in the concentration of blood cortisol and testosterone. The dynamics of cortisol concentration in the adrenal glands was similar, while chan...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-009-0396-3

    authors: Palchikova NA,Kuzminova OI,Utkina NV,Selyatitskaya VG,Shkurupiy VA

    更新日期:2008-12-01 00:00:00

  • Immunocytochemical analysis of proliferative activity of endometrial and myometrial cell populations in focal and stromal adenomyosis.

    abstract::Immunocytochemical study has shown that Ki-67 antigen is detected in adenomyosis in both endometrial and myometrial cell populations (in the eutopic and ectopic endometrial glandular epithelium, stromal cells, smooth muscle cells, and vascular endotheliocytes of the endometrium and myometrium), the label index differi...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-013-2190-5

    authors: Nepomnyashchikh LM,Lushnikova EL,Molodykh OP,Pichigina AK

    更新日期:2013-08-01 00:00:00

  • Role of NF-κB-dependent signaling in the realization of growth potential of mesenchymal progenitor cells in vitro.

    abstract::Signal pathways of realization of growth potential of mesenchymal progenitor cells related to transcription factor NF-κB were studied in vitro. NF-κB was found to participate in the proliferation and differentiation of progenitor elements that can be blocked by its specific inhibitor oridonin. NF-κB inhibitor aurothio...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-013-2236-8

    authors: Zyuz'kov GN,Danilets MG,Ligacheva AA,Zhdanov VV,Udut EV,Miroshnichenko LA,Simanina EV,Trofimova ES,Minakova MY,Chaikovskii AV,Agafonov VI,Dygai AM

    更新日期:2013-10-01 00:00:00