Polymorphism of Matrix Metalloproteinases Genes MMP1, MMP2, MMP3, and MMP7 and the Risk of Varicose Veins of Lower Extremities.

Abstract:

:We studied the effects of single nucleotide polymorphisms in the promoter regions of matrix metalloproteinase genes rs1799750 (-1607dupG) MMP1, rs243865 (C-1306T) MMP2, rs3025058 (-1171dupA) MMP3, and rs11568818 (A-181G) MMP7 on the risk of varicose vein of the lower extremities in ethnical Russians, residents of the Russian Federation. We genotyped 536 patients with this pathology and 273 healthy participants without history of chronic venous disease. Association was examined using logistic regression analysis. None of the studied polymorphisms showed statistically significant association with the risk of varicose veins of the lower extremities. Our results provide evidence that these polymorphisms are not involved in the pathogenesis of varicose veins and cannot serve as markers of predisposition to this pathology.

journal_name

Bull Exp Biol Med

authors

Shadrina AS,Smetanina MA,Sevost'yanova KS,Shevela AI,Seliverstov EI,Zakharova EA,Voronina EN,Ilyukhin EA,Zolotukhin IA,Kirienko AI,Filipenko ML

doi

10.1007/s10517-017-3871-2

subject

Has Abstract

pub_date

2017-09-01 00:00:00

pages

650-654

issue

5

eissn

0007-4888

issn

1573-8221

pii

10.1007/s10517-017-3871-2

journal_volume

163

pub_type

杂志文章
  • Effect of opioids on mechanoreflexive respiration control.

    abstract::The effects of opioids (morphine and fentanyl) on the function of mechanoreceptive respiration regulatory loop were demonstrated. In most opioid-treated rats (74% cases) vagotomy was followed by apneustic respiration with inspiration pause. Excess of opioids in rat CNS produced minor disturbances in the respiration rh...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-005-0301-7

    authors: Tarakanov IA,Tikhomirova LN,Safonov VA

    更新日期:2005-04-01 00:00:00

  • Bacterial markers of periodontal diseases and their practical significance in dentistry.

    abstract::The incidence and prevalence of Actinobacillus actinomycetemcomitans, Porphyronmonas gingivalis, and Tannerella forsythensis in specimens of subgingival dental deposit were evaluated in 495 residents of St. Petersburg aged 6-82 years. The microorganisms were detected by gene-specific PCR of 16S rDNA. In accordance wit...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-007-0374-6

    authors: Chukhlovin AB,Solovyova AM,Matelo SK,Kobiyasova IV,Morosova EB,Hokhlacheva AV,Teplyakov BG,Syssoev KA,Konstantinova VE,Matelo LN,Totolian AA

    更新日期:2007-10-01 00:00:00

  • Expression of type IV collagen by Lewis pulmonary carcinoma cells.

    abstract::Study of the expression of type IV collagen by Lewis pulmonary carcinoma cells (PLMG-T, PLMG-M1, PLMG-M2) showed that these cells produce type IV collagen. The expression of type IV collagen in PLMG-T and PLMG-M2 cells approximately 2-fold surpassed that in PLMG-M1 cells. The number of active cells (synthesizing type ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/b:bebm.0000024390.08829.ee

    authors: Gaenko GP,Khaidukov SV,Molotkovskii YG

    更新日期:2004-01-01 00:00:00

  • Preventive and therapeutic effect of complex antioxidant preparation in rats with burn trauma.

    abstract::The production of blood radicals and activity of superoxide dismutase in erythrocytes increased in rats with contact burn trauma (20%). In animals with burn trauma antioxidant activity of the plasma was much lower, while myeloperoxidase content in the lung tissue and epidermis was higher than in control rats. The comp...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-005-0017-8

    authors: Mikhal'chik EV,Ivanova AV,Anurov MV,Titkova SM,Pen'kov LY,Korkina LG

    更新日期:2004-09-01 00:00:00

  • Effects of titanium dioxide nanoparticles on small intestinal mucosa in rats.

    abstract::Penetration of titanium dioxide nanoparticles into enterocytes after their administration into isolated loop of rat small intestine was shown in vivo by transmission electron microscopy. Using electron diffraction, titanium dioxide nanoparticles were identified in the apical regions of the cells under plasma membranes...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-012-1928-9

    authors: Onishchenko GE,Erokhina MV,Abramchuk SS,Shaitan KV,Raspopov RV,Smirnova VV,Vasilevskaya LS,Gmoshinski IV,Kirpichnikov MP,Tutelyan VA

    更新日期:2012-12-01 00:00:00

  • Effects of antibodies to glutamate on focal penicillin-induced epileptic activity.

    abstract::The effects of intranasal pretreatment with antibodies against glutamate on focal penicillin-induced epileptic activity were studied by recording electrocorticogram in non-anesthetized freely moving male Wistar rats. Anticonvulsant effects of intranasal administration of anti-glutamate antibodies (300 μg/kg) 1 h befor...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-013-2206-1

    authors: Kuznetsova LV,Karpova MN,Vetrile LA,Klishina NY

    更新日期:2013-09-01 00:00:00

  • Oxyquinoline-Dependent Changes in Claudin-Encoding Genes Contribute to Impairment of the Barrier Function of the Trophoblast Monolayer.

    abstract::Natural response to hypoxia critically depends on rapid stabilization of hypoxia-inducible factor (HIF). Under normoxic conditions, HIF-prolyl hydroxylases mark α-subunits of HIF for degradation, while hypoxia results in stabilization of HIF-α. Oxyquinoline derivatives suppress activity of HIF-prolyl hydroxylases lead...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-019-04352-z

    authors: Knyazev EN,Petrov VA,Gazizov IN,Gerasimenko TN,Tsypina IM,Tonevitsky AG,Sukhikh GT

    更新日期:2019-01-01 00:00:00

  • Formation and some cytophysiological characteristics of polynuclear macrophages in primary cultures of peritoneal cells.

    abstract::We studied the formation and cytophysiological characteristics of polynuclear macrophages in primary cultures of peritoneal cells from C57Bl/6 mice. Production of reactive oxygen species and phagocytic activity in polynuclear macrophages were higher than in mononuclear macrophages. The formation of polynuclear macroph...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-009-0405-6

    authors: Arkhipov SA,Shkurupiy VA,Ijine DA,Ignatovich NV,Akhromenko ES,Arkhipova VV

    更新日期:2008-12-01 00:00:00

  • On Methods for the Analysis of Indefinite Stimuli Perception Characteristics: an fMRT Study of Gender-Specific Differences.

    abstract::Comparative identification of cerebral regions activated in men and women during perception of indefinite images was carried out by fMRT and psychological testing. Nine men and nine women aged 20-26 years took part in the study. The volunteers examined simple geometric figures, slightly structurized images (tables fro...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 临床试验,杂志文章

    doi:10.1007/s10517-016-3431-1

    authors: Fyodorov AA,Pervushina ON,Bliznyuk MV,Khoroshilov BM,Melnikov ME,Mazhirina KG,Stark MB,Savelov AA,Petrovsky ED,Kozlova LI

    更新日期:2016-07-01 00:00:00

  • Effect of a synthetic indolicidin analogue on lipid peroxidation in thermal burns.

    abstract::Experimental simulation of burn was followed by accumulation of LPO products and suppression of antioxidant enzyme activity in the burn wound. Application of a synthetic analogue of indolicidin led to an increase in MDA and acylhydroperoxide concentrations in the burn wound on experimental day 1. Further application o...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-014-2587-9

    authors: Lazarenko VA,Lyashev YD,Shevchenko NI

    更新日期:2014-08-01 00:00:00

  • Effect of low-intensity laser radiation of the red spectrum on some properties of erythrocytes in Wistar rats.

    abstract::Laser radiation of different power had various effects on the properties of erythrocytes. An increase in the radiation power from 2.2 to 25 mW/cm2 was accompanied by a decrease in the erythrocyte sedimentation rate and an increase in erythrocyte filtration index. Radiation of 50 mW/cm2 induced abnormal erythrocyte agg...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-008-0020-y

    authors: Lin'kova NS,Gorshkova OP,Shuvaeva VN,Dvoretskii DP

    更新日期:2008-01-01 00:00:00

  • Additivity and independence of neuroprotective effects of GABAA and GABAB receptor agonists in complete global cerebral ischemia.

    abstract::Neuroprotective effects of GABA(B) agonist baclofen and GABA(A) agonists THIP and muscimol are completely additive. GABAA and GABA(B) receptor antagonists block the neuroprotective effects of the corresponding agonists without cross-blocking. In fact, the blockade of combined effect of two agonists with selective GABA...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/BF02766091

    authors: Kulinskii VI,Mikhel'son GV

    更新日期:2000-08-01 00:00:00

  • Correlations of arterial hemodynamics with the severity of clinical manifestations of vertebrobasilar insufficiency.

    abstract::A variety of clinical manifestations of vertebrobasilar insufficiency in virtually the same anatomical disorders of the vertebral arteries indicates the multilevel regulation of the cerebral bloodflow aimed at its stabilization and maintenance. The main arteries of the head and peripheral arteries were studied by Dopp...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-009-0299-3

    authors: Vokina TA,Tkachenko SB,Beresten NF,Tvalavadze VV

    更新日期:2008-10-01 00:00:00

  • Parameters of cell energy metabolism during stress in laboratory animals and energotropic effect of alpha1-adrenoblocker doxazosin.

    abstract::Cytochemical activity of succinate dehydrogenase and lactate dehydrogenase in blood lymphocytes, activity of hydroperoxides, MDA, and blood plasma antioxidants were studied in experimental animals during immobilization stress after preliminary injection of doxazosin. Preliminary adrenergic receptor blockade prevented ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-005-0064-1

    authors: Vishnevskii EL,Vishnevskii AE,Shabel'nikova EI,Safronova ON,Dreval AA,Topchieva GV,Sukhorukov VS

    更新日期:2004-11-01 00:00:00

  • Effect of epidural injection of prosidol with clonidine on the state of spinal cord and spinal ganglion.

    abstract::Morphological and histoenzymatic changes in cells of the spinal cord and spinal ganglia after epidural injection of a combination of prosidol with clonidine were studied on dogs. No pathological structural and metabolic changes in the nervous tissue were found after combined treatment with the test drugs. Higher activ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/a:1013195407388

    authors: Volchkov VA,Strashnov VI,Tomson VV,Boikova NV,Zaitsev AA

    更新日期:2001-09-01 00:00:00

  • Effect of gold nanoparticles coated with plasma components on ADP-induced platelet aggregation.

    abstract::We studied the effect of gold nanospheres coated with components of autologous blood plasma on ADP-induced platelet aggregation. Gold nanoparticles in the chosen concentration range (5-40 μM) and particle size (5-30 nm) with or without coating produced no activating effect on platelet aggregation caused by aggregation...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-013-2226-x

    authors: Aseychev AV,Azizova OA,Beckman EM,Dudnik LB,Sergienko VI

    更新日期:2013-09-01 00:00:00

  • Contribution of protein synthesis to mechanisms of antiepileptic system activity in kindling.

    abstract::We studied changes in protein composition and their effects on convulsive activity in drug-induced and electrical kindling. Injection of protein fraction of brain extract from animals subjected to metronidazole-induced kindling to intact recipients reduced their sensitivity to the convulsant (i. e. increased the dose ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/a:1020265305153

    authors: Karpova MN,Karganov MY,Klishina NY,Khlebnikova NN,Kryzhanovskii GN

    更新日期:2002-06-01 00:00:00

  • Cytological analysis of choledochal mucosa in acute cholangitis in patients with mechanical jaundice.

    abstract::Changes in bile ducts in cholestasis are characterized by activation of proliferation and hypertrophy of cholangiocytes and degenerative and necrobiotic changes in ductal epithelium. Long-term cholestasis led to massive necrosis of cholangiocytes. Inflammatory changes in the choledochal mucosa were most pronounced in ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/a:1016274827348

    authors: Dreval' AA,Perminova GI,Kuznetsov NA,Sokolov AA,Laberko LA,Ryzhkova LV

    更新日期:2002-04-01 00:00:00

  • Changes in heart rate of rats subjected to treadmill training.

    abstract::The mechanisms of extracardiac regulation of heart rate were studied in rats subjected to muscle training on a treadmill with different slope angle (0 degrees , 5.5 degrees up, and 5.5 degrees down). Muscle training on a treadmill sloping down was optimal for the development of training bradycardia in 70-day-old rats....

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-009-0361-1

    authors: Abzalov RA,Ryabysheva SS

    更新日期:2008-11-01 00:00:00

  • Apoptosis regulator proteins: basis for the development of innovation strategies for the treatment of rheumatoid arthritis in patients of different age.

    abstract::Apoptosis markers (p53, PUMA, p21, and Mdm2) were studied in patients with rheumatoid arthritis at the early and late stages of disease on bone marrow smears and frozen sections of the articular synovial membrane. The target molecules were found in all patients. The early stage was characterized by maximum expression ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-014-2353-z

    authors: Doroshevskaya AY,Kondratovskii PM,Dubikov AI,Eliseikina MG

    更新日期:2014-01-01 00:00:00

  • Effect of photodynamic therapy with photodithazine on morphofunctional parameters of M-1 sarcoma.

    abstract::Efficiency and mechanisms of action of photodynamic therapy of M-1 sarcoma were studied experimentally on rats using photodithazine, a novel chlorine photosensitizer. The tissue and cellular targets for this agent are vascular wall, plasma membrane of tumor cells, and intracellular structures responsible for prolifera...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-005-0133-5

    authors: Romanko YS,Tsyb AF,Kaplan MA,Popuchiev VV

    更新日期:2004-12-01 00:00:00

  • Relationship between H+ transfer through human erythrocyte membrane and temperature.

    abstract::The parameters of thermal dependence of H+ transport into human erythrocytes in the presence of furosemide were measured. The relationship between these changes and function of band 3 protein of the erythrocyte membrane is discussed. ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/b:bebm.0000046935.36523.a4

    authors: Mishchenko AA,Irzhak LI

    更新日期:2004-07-01 00:00:00

  • Nongenomic effect of androgens on Ca(2+) concentration in human lymphocytes.

    abstract::Testosterone and its high-molecular-weight form (testosterone covalently immobilized on bovine serum albumin) induced a rise of intracellular calcium concentration. The effectiveness of dihydrotestosterone was much lower compared to that of testosterone. Gestagens drospirenone and, to a lesser extent, 17alpha-acetoxy-...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-007-0193-9

    authors: Popova NY,Dukhanin AS,Shimanovskii NL

    更新日期:2007-05-01 00:00:00

  • Effect of Linagliptin on Structural Changes in the Kidney in Experimental Type 2 Diabetes Mellitus.

    abstract::Effect of the dipeptidyl peptidase-4 inhibitor linagliptin on structural manifestations of diabetic nephropathy was studied in BKS.Cg-Dock7m+/+Leprdb/J mice (experimental model of type 2 diabetes mellitus). Linagliptin (10 mg/kg per day) or vehicle was administered by gavage over 8 weeks. Mesangial expansion, thickeni...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-016-3447-6

    authors: Gavrilova YS,Bgatova NP,Klimontov VV,Ischenko IY,Michurina SV,Myakina NE,Zavyalov EL

    更新日期:2016-08-01 00:00:00

  • Reflection of induced and amplified food motivation in impulse activity of the masticatory muscles during electrostimulation of the "hunger center" in the lateral hypothalamus in rabbits.

    abstract::We studied reflection of artificially induced and amplified food motivation in impulse activity of the masticatory muscles during electrostimulation of "hunger center" of the lateral hypothalamus in the absence and presence of food. The threshold stimulation of the lateral hypothalamus in hungry and satiated animals i...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-012-1602-2

    authors: Ignatova JP,Kromin AA

    更新日期:2012-04-01 00:00:00

  • Transplantation of bone marrow mononuclear cells does not affect postinfarction electrical remodeling of the heart.

    abstract::We studied the effect of allotransplantation of bone marrow mononuclear cells on postinfarction remodeling of the heart in rats. The cells were transplanted into the periinfarction zone of the heart. The transplantation was performed on day 9 after coronary occlusion. It was found that on day 45 after coronary occlusi...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-008-0029-2

    authors: Maslov LN,Shakhov VP,Krylatov AV,Platonov AA

    更新日期:2008-01-01 00:00:00

  • Characteristics of bacterial biofilms during long-term culturing.

    abstract::We studied properties of bacterial biofilms during long-term culturing. The biofilms were preserved for more than 90 days under the chosen conditions. At the same time, amounts of matrix and cells underwent periodic changes. The biomass of the biofilms decreased approximately every 7 days and then returned to the prev...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-013-2180-7

    authors: Tetz GV,Artemenko NK,Zaslavskaya NV,Tetz VV

    更新日期:2013-08-01 00:00:00

  • Effect of Linagliptin on the Ratio of Apoptosis Regulators in the Model of Non-Alcoholic Fatty Liver Disease in db/db Mice.

    abstract::We studied the effects of dipeptidyl peptidase 4 (DPP4) inhibitor linagliptin on the expression of apoptosis regulator proteins Bcl-2 and Bad in the liver of db/db mice with genetically determined obesity and type 2 diabetes mellitus. The mice received daily linagliptin or saline (placebo) by gavage from week 10 to we...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-019-04493-1

    authors: Michurina SV,Cherepanova MA,Ishchenko IY,Arkhipov SA,Klimontov VV,Zav'yalov EL

    更新日期:2019-06-01 00:00:00

  • Parameters of cell immune response in Wistar and OXYS rats and their behavior in the open field test.

    abstract::Comparative analysis of the state of the thymus, activity of cell component of the immune system, and open field behavior of Wistar and OXYS rats showed early involution of the thymus in OXYS rats. By morphological picture this involution corresponded to accidental involution and was paralleled by low level of delayed...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/b:bebm.0000020212.10768.9a

    authors: Markova EV,Obukhova LA,Kolosova NG

    更新日期:2003-12-01 00:00:00

  • Participation of IIb-IIIa glycoprotein in spontaneous platelet aggregation.

    abstract::In some patients with stable and unstable angina pectoris and in some donors without clinical manifestations of cardiovascular diseases and other pathologies, spontaneous platelet aggregation was completely suppressed by glycoprotein IIb-IIIa antagonists blocking the interaction of this glycoprotein with fibrinogen. A...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-007-0146-3

    authors: Sirotkina OV,Zabotina AM,Taraskina AE,Sivachenko EB,Zueva EE,Kadinskaya MI,Buryachkovskaya LI,Uchitel' IA,Khaspekova SG,Vavilova TV,Shvartsman AL,Mazurov AV

    更新日期:2007-04-01 00:00:00