Abstract:
:We studied the effects of single nucleotide polymorphisms in the promoter regions of matrix metalloproteinase genes rs1799750 (-1607dupG) MMP1, rs243865 (C-1306T) MMP2, rs3025058 (-1171dupA) MMP3, and rs11568818 (A-181G) MMP7 on the risk of varicose vein of the lower extremities in ethnical Russians, residents of the Russian Federation. We genotyped 536 patients with this pathology and 273 healthy participants without history of chronic venous disease. Association was examined using logistic regression analysis. None of the studied polymorphisms showed statistically significant association with the risk of varicose veins of the lower extremities. Our results provide evidence that these polymorphisms are not involved in the pathogenesis of varicose veins and cannot serve as markers of predisposition to this pathology.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Shadrina AS,Smetanina MA,Sevost'yanova KS,Shevela AI,Seliverstov EI,Zakharova EA,Voronina EN,Ilyukhin EA,Zolotukhin IA,Kirienko AI,Filipenko MLdoi
10.1007/s10517-017-3871-2subject
Has Abstractpub_date
2017-09-01 00:00:00pages
650-654issue
5eissn
0007-4888issn
1573-8221pii
10.1007/s10517-017-3871-2journal_volume
163pub_type
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