Abstract：
:Effects of Miramistin and Phosprenil on biofilms of S. pyogenes, S. aureus, E. coli, L. acidophilus, and L. plantarum were studied. Significant differences in the effects of these substances on mature biofilms of microorganisms and the process of their formation were observed. Miramistin had significant inhibiting effects on the forming of biofilms and on the formed biofilms of all studied microorganisms. Treatment with Miramistin inhibited biofilm formation by 2-3 times compared to the control. This effect was found already after using of Miramistin in the low doses (3.12 μg/ml). Inhibition of the growth of a formed biofilm was observed only after treatment with Miramistin in the high doses (25-50 μg/ml). Phosprenil in the high doses (15-30 mg/ml) inhibited the forming of biofilms, especially the biofilms of S. pyogenes and L. plantarum (by 3-4.5 times). Treatment of formed biofilms with the agent in doses of 6.0 and 0.6 mg/ml was associated with pronounced stimulation of its growth in S. pyogenes, S. aureus, and L. acidophilus.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Danilova TA,Danilina GA,Adzhieva AA,Minko AG,Nikolaeva TN,Zhukhovitskii VG,Pronin AVdoi
10.1007/s10517-017-3823-xsubject
Has Abstractpub_date
2017-08-01 00:00:00pages
439-442issue
4eissn
0007-4888issn
1573-8221pii
10.1007/s10517-017-3823-xjournal_volume
163pub_type
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