Abstract:
:Testosterone and its high-molecular-weight form (testosterone covalently immobilized on bovine serum albumin) induced a rise of intracellular calcium concentration. The effectiveness of dihydrotestosterone was much lower compared to that of testosterone. Gestagens drospirenone and, to a lesser extent, 17alpha-acetoxy-3beta-butanoyloxy-6-methyl-pregna-4,6-dien-20-one prevented the testosterone-induced Ca(2+) entry into cells. Antagonist of intracellular androgen receptors cyproterone acetate had no effect on testosterone-induced variations in calcium concentration. Human lymphocytes can be used as an experimental test system for screening and evaluation of the molecular mechanisms of nongenomic membranotropic effect of androgens and new compounds with antiandrogen activity.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Popova NY,Dukhanin AS,Shimanovskii NLdoi
10.1007/s10517-007-0193-9subject
Has Abstractpub_date
2007-05-01 00:00:00pages
605-7issue
5eissn
0007-4888issn
1573-8221pii
doijournal_volume
143pub_type
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