Abstract：
:The development of dissociated cells from rat embryonic spinal ganglion after transplantation to damaged nerve of adult animals was studied using immunohistochemical differentiation markers of neural and glial cells. The cell suspension obtained after dissociation of rat embryonic spinal ganglia (embryonic day 15) was injected into the proximal segment of crushed sciatic nerve. The nerve was damaged by ligation for 40 sec. Progenitor cells were labeled with 5-bromo-2'-deoxyuridine (BrdU) before transplantation. BrdU-immunopositive cells were detected in the nerve trunks of recipients on days 1, 21, and 28 after transplantation. Dissociated cells of rat embryonic spinal ganglion (embryonic day 15) survived for at least 4 weeks after transplantation to the nerve and differentiate into NeuN-immunopositive neurons with morphological properties of sensory neurons and satellite cells containing S100 protein.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Petrova ES,Isaeva EN,Korzhevskii DEdoi
10.1007/s10517-014-2633-7subject
Has Abstractpub_date
2014-09-01 00:00:00pages
637-40issue
5eissn
0007-4888issn
1573-8221journal_volume
157pub_type
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