Effect of glyprolines on homeostasis of gastric mucosa in rats with stress ulcers.

Abstract:

:Pro-Gly-Pro and its metabolite Gly-Pro effectively prevented the development of erosive and ulcerative lesions of the gastric mucosa in rats under conditions of water-immersion restraint stress by restoring the oxidatant-antioxidant balance in the total fraction of gastric mucosa cells. Pro-Gly was least effective in this respect. We conclude that glyprolines hold much promise as pharmaceutical products, which can be used in gastroenterological practice for the prevention and therapy of ulcer disease of the stomach and duodenum.

journal_name

Bull Exp Biol Med

authors

Falalyeyeva TM,Samonina GE,Beregovaya TV,Andreeva LA,Dvorshchenko EV

doi

10.1007/s10517-010-0866-7

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

26-8

issue

1

eissn

0007-4888

issn

1573-8221

journal_volume

149

pub_type

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