Abstract：
:We studied the rate of development of tolerance to the ethanol-induced analgesia under the effect of μ-, δ-, and κ-opioid agonists and antagonists not crossing the blood-brain barrier and rapidly inactivated by gastric and duodenal proteolytic enzymes. Activation of gastric κ-opioid receptors eliminated the analgesic effect of ethanol and accelerated the development of tolerance to ethanol-induced analgesia. In contrast, activation of gastric μ-opioid receptors decelerated the development of this tolerance. Activation of gastric δ-opioid receptors produced no effect on examined tolerance. μ-Opioid receptor antagonist decelerated and δ-opioid receptor antagonist accelerated the development of tolerance to ethanol-induced analgesia. Thus, the state of gastric opioid receptors affects the manifestation of ethanol-induced analgesia and the development of tolerance to this effect.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Sudakov SK,Alekseeva EV,Nazarova GAdoi
10.1007/s10517-017-3760-8subject
Has Abstractpub_date
2017-06-01 00:00:00pages
177-179issue
2eissn
0007-4888issn
1573-8221pii
10.1007/s10517-017-3760-8journal_volume
163pub_type
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