Abstract：
:Model experiments on biomicroscopy of mesenteric microvessels in laboratory rats were performed to evaluate the effect of natural metabolites (e.g., amino acid glycine) on the microcirculation. The effect of glycine was determined from a change in the diameter of arterioles. Application of glycine (0.1 ml, 1 M) to the mesenteric surface was followed by arteriolar dilation (by 50-80%). Histamine-induced disturbances in the microcirculation were not observed after preapplication of glycine. Under these conditions, pretreatment with histamine was accompanied by reversible changes. Our results suggest that the natural metabolite glycine has a prophylactic and therapeutic effect on microcirculatory disturbances, which are induced by inflammatory-and-allergic mediator histamine.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Podoprigora GI,Nartsissov YRdoi
10.1007/s10517-009-0498-ysubject
Has Abstractpub_date
2009-03-01 00:00:00pages
308-11issue
3eissn
0007-4888issn
1573-8221journal_volume
147pub_type
杂志文章abstract：:The effect of serotoninotropic substances with positive and negative effects on serum concentrations of thyrotropic hormone, total triiodothyronine, and total thyroxin was studied in old male rats. Chronic treatment with L-tryptophan and citalopram reduced serum level of total thyroxin in old intact animals and serum ...
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