Abstract：
:Telocytes, a new type of interstitial stem cells with long thin processes that form a three-dimensional network around cardiomyocytes, vessels, and nerve fibers were described in the myocardium of children with tetralogy of Fallot. Two types of morphologically different telocytes, spindle-shaped and rounded, were identified. Contacts of telocytes with stem cells and interstitial macrophages were found. Telocytes were more common in the immature myocardium, where the assembly of myofibrils in cardiomyocytes was not completed and small Ki-67+ cardiomyocyte progenitor cells were present. Telocytes expressed immunohistochemical markers CD117, vimentin, CD34, and CD44. Localization and ultrastructural characteristics of telocytes suggested their participation in stem cell differentiation, coordination of neoangiogenesis, and paracrine regulation of all components of the interstitium.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Sukhacheva TV,Nizyaeva NV,Samsonova MV,Chernyaev AL,Shchegolev AI,Serov RAdoi
10.1007/s10517-020-04840-7subject
Has Abstractpub_date
2020-05-01 00:00:00pages
137-146issue
1eissn
0007-4888issn
1573-8221pii
10.1007/s10517-020-04840-7journal_volume
169pub_type
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