Serum Level of HLDF24 Peptide as an Objective Marker of Prehypertension.

Abstract:

:The concentrations of the key factors of molecular pathogenesis of prehypertension (angiotensin II, HLDF24, S100b, endothelin, autoantibodies to these molecules, and VEGF) were analyzed in subjects with optimal BP (<120/80 mm Hg) and prehypertension (120-139/80-89 mm Hg). Comparative and correlation analysis of the levels of these molecules was performed. A statistically significant decrease in HLDF24 level in prehypertension in comparison optimal BP was observed. Specific features and interactions between the studied factors in optimal BP and in prehypertension were studied. The mechanisms underlying the observed associations between serum concentration of HLFF24 and the development of prehypertension were discussed.

journal_name

Bull Exp Biol Med

authors

Sherstnev VV,Gruden MA,Karlina VP,Ryzhov VM,Kuznetsova AV,Senko OV

doi

10.1007/s10517-020-04696-x

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

305-308

issue

3

eissn

0007-4888

issn

1573-8221

pii

10.1007/s10517-020-04696-x

journal_volume

168

pub_type

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