Abstract:
:The concentrations of the key factors of molecular pathogenesis of prehypertension (angiotensin II, HLDF24, S100b, endothelin, autoantibodies to these molecules, and VEGF) were analyzed in subjects with optimal BP (<120/80 mm Hg) and prehypertension (120-139/80-89 mm Hg). Comparative and correlation analysis of the levels of these molecules was performed. A statistically significant decrease in HLDF24 level in prehypertension in comparison optimal BP was observed. Specific features and interactions between the studied factors in optimal BP and in prehypertension were studied. The mechanisms underlying the observed associations between serum concentration of HLFF24 and the development of prehypertension were discussed.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Sherstnev VV,Gruden MA,Karlina VP,Ryzhov VM,Kuznetsova AV,Senko OVdoi
10.1007/s10517-020-04696-xsubject
Has Abstractpub_date
2020-01-01 00:00:00pages
305-308issue
3eissn
0007-4888issn
1573-8221pii
10.1007/s10517-020-04696-xjournal_volume
168pub_type
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