Abstract：
:We studied the effect of adrenal cortex hormone dehydroepiandrosterone sulfate on maturation and functional activity of interferon-alpha-induced dendritic cells. Dehydroepiandrosterone sulfate stimulated differentiation and maturation of interferon-alpha-induced dendritic cell, which manifested in a decrease in the number of CD14(+)cells and increase in the ratio of mature CD83(+)dendritic cells expressing costimulatory molecules (CD80 and CD86). The induction of dendritic cell differentiation after treatment with dehydroepiandrosterone sulfate was accompanied by an increase in the production of interferon-gamma. At the stage of dendritic cell maturation, the effect of dehydroepiandrosterone sulfate manifested in a 4-fold increase in tumor necrosis factor-alpha production. Dehydroepiandrosterone sulfate had little effect on the production of Th2/antiinflammatory cytokines at the stages of differentiation and maturation of interferon-alpha-induced dendritic cells. Dehydroepiandrosterone sulfate increased the ability of dendritic cells to stimulate Th1 cytokine production by T cells (interferon-gamma). This hormone had no effect on the ability of interferon-alpha-induced dendritic cells to activate CD3(+)IL-4(+)T cells in mixed lymphocyte culture.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Leplina OY,Tikhonova MA,Sakchno LV,Tyrinova TV,Ostanin AA,Chernykh ERdoi
10.1007/s10517-009-0619-7subject
Has Abstractpub_date
2009-07-01 00:00:00pages
68-71issue
1eissn
0007-4888issn
1573-8221journal_volume
148pub_type
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