Abstract：
:We studied the role of DNA methylation in the mechanisms of amnesia in edible snails, which was induced by impairment of conditioned food aversion memory reconsolidation with NMDA glutamate receptor antagonist. The effects of DNA methyltransferase inhibitors were shown to depend on the stage of amnesia. At the early stage of amnesia (day 3 after induction), injections of methyltransferase inhibitors in combination with conditioned food stimulus (reminder) were followed by memory recovery. Application of inhibitors in the absence of the reminder was ineffective. Methyltransferase inhibitors were ineffective at the late stage of amnesia (day 10). Our results suggest that the presentation of reminding conditioned stimuli is followed by reactivation of amnesia. Methylation or demethylation of DNA in nerve cells serves as one of the key mechanisms for amnesia.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Solntseva SV,Filatova TS,Nikitin PV,Bredov DV,Kozyrev SA,Nikitin VPdoi
10.1007/s10517-014-2367-6subject
Has Abstractpub_date
2014-02-01 00:00:00pages
430-4issue
4eissn
0007-4888issn
1573-8221journal_volume
156pub_type
杂志文章abstract：:Prostatotropic activity of (3,5-dimethyl-4-hydroxy)benzyl thiododecane (T-DD) was evaluated on a model of benign prostatic hyperplasia induced in Wistar rats by chronic (2 months) intraperitoneal administration of sulpiride (40 mg/kg). Morphometric analysis of the dorsolateral lobe of the prostate showed that after th...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-019-04628-4
更新日期：2019-10-01 00:00:00
abstract：:We measured the content of ROS and malondialdehyde in cells of in vivo drug-resistant murine P388 leukemia strains. It was found that the strains did not differ by malondialdehyde concentration, but intracellular concentration of ROS in cells of the cyclophosphamide-resistant strain (P388/CP) was higher than in cells ...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-020-04861-2
更新日期：2020-06-01 00:00:00
abstract：:Antiviral properties of Hexoral (0.1% solution and 0.2% aerosol for local application) and its constituent hexetidine against viruses causing human respiratory tract infections and herpes virus were studied in vitro. It was found that non-cytotoxic concentrations of hexetidine (alone and as a component of Hexoral) att...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-016-3169-9
更新日期：2016-01-01 00:00:00
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journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1023/a:1015826415361
更新日期：2002-03-01 00:00:00
abstract：:The interaction between recombinant soluble CD4 receptor (rsCD4) with human apolipoprotein A-I was studied by enzyme-linked immunosorbent assay. Our findings suggest that HIV-1 and human apolipoprotein A-I compete for the CD4 receptor and receptor for apoA-I. ...
journal_title：Bulletin of experimental biology and medicine
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doi：10.1023/a:1016233618262
更新日期：2002-04-01 00:00:00
abstract：:The inotropic response of the myocardium to extrasystolic treatment was studied on isolated perfused papillary muscles from rats with postinfarction cardiosclerosis. The development of postinfarction cardiosclerosis was accompanied by a decrease in myocardial excitability. The amplitude of extrasystolic contractions i...
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doi：10.1007/s10517-005-0367-2
更新日期：2005-06-01 00:00:00
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journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章,已发布勘误
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更新日期：2017-09-01 00:00:00
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journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-018-4333-1
更新日期：2018-12-01 00:00:00
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journal_title：Bulletin of experimental biology and medicine
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更新日期：2007-01-01 00:00:00
abstract：:Immunization of mice with synthetic peptide fragments of conservative sites of meningococcal outer membrane proteins led to defense formation against infection with virulent serogroup A and B Meningococci. The role of cellular immunity in the formation of defense against meningococcal infection after immunization with...
journal_title：Bulletin of experimental biology and medicine
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doi：10.1007/s10517-007-0223-7
更新日期：2007-06-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s10517-018-4062-5
更新日期：2018-04-01 00:00:00
abstract：:Digital simulation of disorders in the p53 and Mdm2 protein system, involved in repair of DNA defects and in many vital processes, including tumor formation, neurodegeneration, and aging, was carried out on the base of functional nonlinear octoparametric mathematical model. Stress situations were studied, associated w...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-014-2608-8
更新日期：2014-08-01 00:00:00
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journal_title：Bulletin of experimental biology and medicine
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doi：10.1007/s10517-008-0177-4
更新日期：2008-06-01 00:00:00
abstract：:The content of urokinase- and tissue-type plasminogen activators and plasminogen activator inhibitor PAI-1 in the cytosol of primary and metastatic melanomas and benign skin pigment neoplasms was estimated by enzyme immunoassay. It was shown that local growth and invasion of melanomas are related to suppressed express...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1023/a:1012532412896
更新日期：2001-07-01 00:00:00
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journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1023/a:1012342300406
更新日期：2001-06-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s10517-018-4215-6
更新日期：2018-08-01 00:00:00
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journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：
更新日期：2000-11-01 00:00:00
abstract：:The efficiency of ascorbate and alpha-tocopherol as stabilizers of beta-carotene, which is widely used in complex therapy and prevention of some diseases accompanied by oxidative stress, was studied. The latency of induced beta-carotene oxidation linearly depends on ascorbate concentration, while steady-state rate non...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/BF02682099
更新日期：2000-07-01 00:00:00
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journal_title：Bulletin of experimental biology and medicine
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更新日期：2018-03-01 00:00:00
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journal_title：Bulletin of experimental biology and medicine
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pub_type： 杂志文章
doi：10.1007/s10517-015-2872-2
更新日期：2015-04-01 00:00:00
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journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
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更新日期：2012-09-01 00:00:00
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journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-014-2683-x
更新日期：2014-11-01 00:00:00
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journal_title：Bulletin of experimental biology and medicine
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更新日期：2008-11-01 00:00:00
abstract：:hyperthermia caused hemodynamic disorders in the liver and degenerative and necrobiotic changes in hepatocytes of CBA mice. Total hepatocyte count decreased during restitution, this decrease being most pronounced 30 min after exposure. The number of binucleated cells also markedly decreased. The absence of necrotic ch...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：
更新日期：2000-09-01 00:00:00
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更新日期：2021-01-01 00:00:00
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journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-011-1138-x
更新日期：2011-01-01 00:00:00
abstract：:Applications of cold and warm activated cellular immunity and orientation and exploratory behavior in mice. Application of cold increased the number of turns to the left in the open field, muscle force, and activity of the food instinct, and caused an increase in the total count of peripheral blood leukocytes. Warm ap...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-013-2052-1
更新日期：2013-04-01 00:00:00
abstract：:We performed immunohistochemical analysis of the expression of TGFβ, galectin-1, vimentin, and thrombospondin in the mucosa in gastric cancer of diffuse and intestinal type associated with systemic undifferentiated connective tissue dysplasia. In diffuse gastric cancer, both with and without association with connectiv...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-019-04438-8
更新日期：2019-04-01 00:00:00
