Inotropic response of the myocardium in rats with postinfarction cardiosclerosis exposed to extrasystolic treatment.

Abstract:

:The inotropic response of the myocardium to extrasystolic treatment was studied on isolated perfused papillary muscles from rats with postinfarction cardiosclerosis. The development of postinfarction cardiosclerosis was accompanied by a decrease in myocardial excitability. The amplitude of extrasystolic contractions in the remodeled myocardium far surpassed the control. However, the amplitude of postextrasystolic contraction did not surpass that in normal contraction-relaxation cycle. Our results suggest that the ability of the sarcoplasmic reticulum in cardiomyocytes to accumulate Ca2+ is impaired during postinfarction remodeling.

journal_name

Bull Exp Biol Med

authors

Kondrat'eva DS,Afanas'ev SA,Falaleeva LP,Shakhov VP

doi

10.1007/s10517-005-0367-2

subject

Has Abstract

pub_date

2005-06-01 00:00:00

pages

647-50

issue

6

eissn

0007-4888

issn

1573-8221

pii

doi

journal_volume

139

pub_type

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