Abstract:
:The inotropic response of the myocardium to extrasystolic treatment was studied on isolated perfused papillary muscles from rats with postinfarction cardiosclerosis. The development of postinfarction cardiosclerosis was accompanied by a decrease in myocardial excitability. The amplitude of extrasystolic contractions in the remodeled myocardium far surpassed the control. However, the amplitude of postextrasystolic contraction did not surpass that in normal contraction-relaxation cycle. Our results suggest that the ability of the sarcoplasmic reticulum in cardiomyocytes to accumulate Ca2+ is impaired during postinfarction remodeling.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Kondrat'eva DS,Afanas'ev SA,Falaleeva LP,Shakhov VPdoi
10.1007/s10517-005-0367-2subject
Has Abstractpub_date
2005-06-01 00:00:00pages
647-50issue
6eissn
0007-4888issn
1573-8221pii
doijournal_volume
139pub_type
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