Biocompatibility and Bioresorption of 3D-Printed Polylactide and Polyglycolide Tissue Membranes.

abstract：:Levosimendan is effective in the therapy of chronic heart failure in both mature and old rats, but the duration of its therapeutic effect differs in these age groups. In 15 days after treatment, the myocardium in old rats maintained augmented functionality, whereas in old animals, functional potencies returned to the ...

journal_title：Bulletin of experimental biology and medicine

authors： Mamalyga ML,Mamalyga LM

更新日期：2020-05-01 00:00:00

abstract：:The dynamics of coenzyme Q10 concentration in the blood plasma, liver, and brain of passive and active rats was studied on the model of metabolic stress. This parameter was shown to differ in rats with various patterns of behavior. Dietary consumption of coenzyme Q10 in doses of 10 and 100 mg/kg body weight was follow...

journal_title：Bulletin of experimental biology and medicine

authors： Kirbaeva NV,Sharanova NE,Baturina VA,Zhminchenko VM,Pertsov SS,Vasil'ev AV

更新日期：2016-09-01 00:00:00

abstract：:We studied expression of malignancy markers galectin-3, cytokeratin-19, HBME-1, fibronectin, and cyclin D1 in cells of benign (n=51), malignant (n=87), and borderline (n=53) tumors. The results indicate that 3.9% benign and 41.5% borderline tumors express malignancy markers (specificity 98-100%). Follow up over 1-10 y...

journal_title：Bulletin of experimental biology and medicine

authors： Abrosimov AY,Dvinskikh NY,Sidorin AV

更新日期：2016-03-01 00:00:00

abstract：:Anticonvulsant activity and pharmacokinetics of nanoemulsion and unmodified substance of carbamazepine were compared in experiments on mice. Carbamazepine nanoemulsion demonstrated significant anticonvulsant activity and was superior to unmodified substance of carbamazepine against seizures induced by maximum electric...

journal_title：Bulletin of experimental biology and medicine

authors： Prokhorov DI,Sariev AK,Abramov DA,Voronina TA,Kapitsa IG,Zhuravko AS,Shiriaeva MV,Kaplun AP,Seifulla RD

更新日期：2014-10-01 00:00:00

abstract：:Afala (ultralow-dose antibodies to prostate-specific antigen) injected for 60 days to rats with hormone-induced prostatitis caused by sulpiride prevented the development of prostatic hyperplasia and reduced the severity of histological changes. The effect of Afala was superior to that of the reference drug (Serenoa re...

journal_title：Bulletin of experimental biology and medicine

authors： Savelieva KV,Borovskaya TG,Kheyfets IA,Dugina JL,Sergeeva SA,Epstein OI

更新日期：2007-11-01 00:00:00

abstract：:Time course of DNase and RNase activities in the sera of random-bred mice infected with Plasmodium malariae (chloroquine-sensitive strain H) was studied. Similarly to viral infection, infection with a protozoa eukaryotic parasite was accompanied by increased DNAse and RNAse activities, though Plasmodium malariae biolo...

journal_title：Bulletin of experimental biology and medicine

authors： Kovalenko GA,Gal'vita AV

更新日期：2000-09-01 00:00:00

abstract：:The incidence of 5 polymorphisms of N-acetyltransferase-2 gene was evaluated in patients with lung cancer. A803G polymorphism is a factor of lung cancer resistance in tobacco smoking Caucasians in Novosibirsk. Opposite effects of NAT2 gene polymorphisms on the risk of lung cancer are possible. ...

journal_title：Bulletin of experimental biology and medicine

authors： Nikishina MV,Vavilin VA,Makarova SI,Lyakhovich VV

更新日期：2007-01-01 00:00:00

abstract：:We studied the incidence of chromosome aberrations in bone marrow cells and primary spermatocytes in various mouse strains. Experiments were performed on SAMP mice (accelerated aging), control SAMR mice, and long-living CBA and SHR mice. Experiments revealed a positive correlation between the age and the incidence of ...

journal_title：Bulletin of experimental biology and medicine

authors： Rozenfel'd SV,Togo EF,Mikheev VS,Popovich IG,Zabezhinskii MA,Anisimov VN

更新日期：2001-05-01 00:00:00

abstract：:The concentrations of proinflammatory cytokines (IL-1beta, IL-6), vascular endothelium growth factor, tumor growth factor-beta, and insulin-like growth factor-1 were measured in the peritoneal fluid of patients with external genital endometriosis and healthy women by enzyme immunoassay. The effect of peritoneal fluid ...

journal_title：Bulletin of experimental biology and medicine

authors： Sokolov DI,Solodovnikova NG,Pavlov OV,Niauri DA,Volkov NN,Sel'kov SA

更新日期：2005-11-01 00:00:00

abstract：:Kinetics of DNA synthesis in mitotic cycle of in mouse corneal epithelial cells after γ-irradiation in different S phase points was studied by the method of autoradiography. Normally, S phase of corneal epithelial cells consists of two phases (S1 and S2) separated by an interval without DNA synthesis. Each phase, in t...

journal_title：Bulletin of experimental biology and medicine

authors： Shabalkin IP,Grigor'eva EY,Shabalkin PI,Gudkova MV

更新日期：2014-11-01 00:00:00

abstract：:Activation of lysosomal proteolysis and increased coenzyme Q10 level were revealed in the liver and brain of rats with individual typological features under conditions of food deprivation. Changes in cathepsin B activity in these tissues were different in behaviorally active and passive animals. We observed indirect m...

journal_title：Bulletin of experimental biology and medicine

authors： Kirbaeva NV,Sharanova NE,Zhminchenko VM,Vasil'ev AV

更新日期：2018-07-01 00:00:00

abstract：:In vivo cytogenetic effects of cyclophosphamide was simultaneously evaluated in 7 mouse organs. Cyclophosphamide produced most pronounced changes in the urinary bladder and bone marrow, the main target organs for this carcinogen. Mutagenic effects of the preparation were also detected in the lungs, large intestine, an...

journal_title：Bulletin of experimental biology and medicine

authors： Sycheva LP

更新日期：2001-04-01 00:00:00

abstract：:A direct relationship between the weights of the brain and hemisphere and parameters characterizing the development of the cortex and its neurons in intact newborn rats was revealed. Parameters of brain development in newborn rats correlate with 3beta-hydroxysteroid dehydrogenase activity in the adrenal zona glomerulo...

journal_title：Bulletin of experimental biology and medicine

authors： Ryzhavskii BY,Matveeva EP,Baranova SN

更新日期：2005-12-01 00:00:00

abstract：:The spatial and the amplitude-temporal parameters of cardiac body surface potentials were examined in female Wistar rats with experimental pulmonary hypertension during ventricular depolarization. The cardiac body surface potentials have been led from 64 subcutaneous electrodes evenly distributed across the chest surf...

journal_title：Bulletin of experimental biology and medicine

authors： Suslonova OV,Smirnova SL,Roshchevskaya IM

更新日期：2016-11-01 00:00:00

abstract：:Inductors of the monooxygenase system benzonal, halonal, and halodif prevented the development of intrahepatic cholestasis induced by a-naphthylisothiocyanate and stimulated detoxifying function of the liver in rats. These agents increased the content of microsomal protein and cytochrome P-450 and accelerated metaboli...

journal_title：Bulletin of experimental biology and medicine

authors： Saratikov AS,Novozheeva TP,Akhmedzhanov RR

更新日期：2002-09-01 00:00:00

abstract：:Changes in bile ducts in cholestasis are characterized by activation of proliferation and hypertrophy of cholangiocytes and degenerative and necrobiotic changes in ductal epithelium. Long-term cholestasis led to massive necrosis of cholangiocytes. Inflammatory changes in the choledochal mucosa were most pronounced in ...

journal_title：Bulletin of experimental biology and medicine

authors： Dreval' AA,Perminova GI,Kuznetsov NA,Sokolov AA,Laberko LA,Ryzhkova LV

更新日期：2002-04-01 00:00:00

abstract：:Results of long-term prospective follow-up of patients with early stages of mitral and aortic valvulitis and primary chronic septic endocarditic are presented. Clinical diagnostics of the diseases is described and the key role is assigned to pathognomic (absolute) clinical symptoms. The tendency to progressive fibrosi...

journal_title：Bulletin of experimental biology and medicine

authors： Bushmanova GM,Zorina IG,Nikityuk DB,Nepomnyashchikh RD,Lapii GA,Postnikova OA,Semenov DE

更新日期：2015-05-01 00:00:00

abstract：:The location and activities of nitric oxide synthases in synovial cells during different stages of inflammatory process were studied by the immunocytochemical method in animals with experimental rheumatoid arthritis. Direct involvement of the NOergic mechanisms in the development of adjuvant arthritis was demonstarted...

journal_title：Bulletin of experimental biology and medicine

authors： Belogolovykh LA,Dubikov AI,Medved' EE

更新日期：2007-05-01 00:00:00

abstract：:Formation of Ala-Glu-Asp-Gly peptide complex with duplex DNA [poly(dA-dT):poly(dA-dT)] at neutral pH and ambient temperature was studied experimentally. Peptide binding to duplex DNA was associated with hyperchromic effect indicating local separation of the double helix. Energies of paired interactions between amino a...

journal_title：Bulletin of experimental biology and medicine

authors： Khavinson VKh,Solovyov AY,Shataeva LK

更新日期：2006-04-01 00:00:00

abstract：:Immunohistochemistry with semi-quantitative analysis of computer images showed that prolactin receptor and cystic fi brosis transmembrane regulator (CFTR) in cholangiocytes of female rats elevated in cholestasis quickly respond to its relief. The effect of hyperprolactinemia on the extent of return of these proteins t...

journal_title：Bulletin of experimental biology and medicine

authors： Aleksandrova MI,Sirotina NS,Smirnova OV

更新日期：2015-07-01 00:00:00

abstract：:We performed a comparative study of the cytotoxicity of cisplatin, JM216 complex, and aminonitroxyl platinum(IV) complexes for HeLa cells grown in monolayer and 3D culture. The growth dynamics of spheroids was studied and optimal conditions for evaluation of cytotoxicity were determined. Spheroids were less sensitive ...

journal_title：Bulletin of experimental biology and medicine

authors： Trigub ММ,Filatova NV,Areshidze DА,Sen' VD,Terentiev АА

更新日期：2020-02-01 00:00:00

abstract：:Glycine stabilizes energetics of brain mitochondria under conditions of brain hypoxia in vivo modeled by ligation of the common carotid artery in rats. Hypoxia reduced respiratory control in brain cortex mitochondria from 7.7 ± 0.5 to 4.5 ± 0.3. Preliminary oral administration of glycine almost completely prevented th...

journal_title：Bulletin of experimental biology and medicine

authors： Selin AA,Lobysheva NV,Vorontsova ON,Tonshin AA,Yaguzhinsky LS,Nartsissov YR

更新日期：2012-05-01 00:00:00

abstract：:In experiments on narcotized rats, BP in the left femoral artery as well as local electrical potential and electrical impedance of the symmetric segment of the right femoral artery were simultaneously recorded in situ with two extracellular nonpolarizable Ag/AgCl electrodes located along the artery at a distance of 3 ...

journal_title：Bulletin of experimental biology and medicine

authors： Revenko SV,Tikhomirova LN,Nesterov AV,Tarakanov IA

更新日期：2018-04-01 00:00:00

abstract：:Rat liver was examined by transmission electron microscopy after a single intravenous injection of nanosized magnetite suspension (0.1 g (Fe(3)O(4))/kg body weight). Magnetite particles were found in Kupffer's cells and hepatocytes. Accumulation of the particles by these two cell types was different. Morphometry of ma...

journal_title：Bulletin of experimental biology and medicine

authors： Mil'to IV,Sukhodolo IV,Miller AA

更新日期：2012-08-01 00:00:00

abstract：:Intraperitoneal administration of substance S-1 to male Wistar rats with impaired hearing markedly increased hearing acuity. Substance S-1 had no negative effects on hearing in intact animals. ...

journal_title：Bulletin of experimental biology and medicine

authors： Shestakova EV

更新日期：2002-01-01 00:00:00

abstract：:hyperthermia caused hemodynamic disorders in the liver and degenerative and necrobiotic changes in hepatocytes of CBA mice. Total hepatocyte count decreased during restitution, this decrease being most pronounced 30 min after exposure. The number of binucleated cells also markedly decreased. The absence of necrotic ch...

journal_title：Bulletin of experimental biology and medicine

authors： Molodykh OP,Nepomnyashchikh LM,Lushnikova EL,Klinnikova MG

更新日期：2000-09-01 00:00:00

abstract：:The mechanisms underlying cardioprotective activity of compound ALM-802 were studied in experiments on rats with chronic post-infarction heart failure. Real-time PCR showed that compound ALM-802 (daily intraperitoneal injections in a dose of 2 mg/kg for 28 days starting from day 91 after myocardial infarction modeling...

journal_title：Bulletin of experimental biology and medicine

authors： Kozhevnikova LM,Barchukov VV,Semenova NP,Vititnova MB,Kryzhanovskii SA

更新日期：2021-01-01 00:00:00

abstract：:The rats with neurodegenerative brain disorder induced by administration of a toxic fragment of beta-amyloid demonstrate weakened endothelium-dependent dilation of cerebral vessels, which attested to impaired production of endothelial NO. At the same time, toxic beta-amyloid fragment induced the formation of NO depots...

journal_title：Bulletin of experimental biology and medicine

authors： Mashina SY,Aleksandrin VV,Goryacheva AV,Vlasova MA,Vanin AF,Malyshev IY,Manukhina EB

更新日期：2006-08-01 00:00:00

abstract：:Neuroprotective effects of GABA(B) agonist baclofen and GABA(A) agonists THIP and muscimol are completely additive. GABAA and GABA(B) receptor antagonists block the neuroprotective effects of the corresponding agonists without cross-blocking. In fact, the blockade of combined effect of two agonists with selective GABA...

journal_title：Bulletin of experimental biology and medicine

authors： Kulinskii VI,Mikhel'son GV

更新日期：2000-08-01 00:00:00

abstract：:We studied the effect of anti-inflammatory cytokine IL-4 on the intensity of free radical processes in emotiogenic brain structures (hypothalamus, sensorimotor cortex, and amygdala) in rats with different prognostic emotional resistance. One-hour immobilization of animals with simultaneous electrocutaneous stimulation...

journal_title：Bulletin of experimental biology and medicine

authors： Pertsov SS,Koplik EV,Kalinichenko LS

更新日期：2011-08-01 00:00:00