Abstract:
:Digital simulation of disorders in the p53 and Mdm2 protein system, involved in repair of DNA defects and in many vital processes, including tumor formation, neurodegeneration, and aging, was carried out on the base of functional nonlinear octoparametric mathematical model. Stress situations were studied, associated with emergence of imbalance in p53 and Mdm2 generation and degradation rates and with disorders in the mechanism of protein interactions, regulated within the framework of the suggested model via dissociation constants. Variants of the analyzed disorders compensation by repeated stress for the system parameters were studied numerically.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Voropaeva OF,Shokin YI,Nepomnyashchikh LM,Senchukova SRdoi
10.1007/s10517-014-2608-8subject
Has Abstractpub_date
2014-08-01 00:00:00pages
535-8issue
4eissn
0007-4888issn
1573-8221journal_volume
157pub_type
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