Mechanisms of defense formation against meningococcal infection in mice immunized with synthetic peptides.

abstract：:Changes in bile ducts in cholestasis are characterized by activation of proliferation and hypertrophy of cholangiocytes and degenerative and necrobiotic changes in ductal epithelium. Long-term cholestasis led to massive necrosis of cholangiocytes. Inflammatory changes in the choledochal mucosa were most pronounced in ...

journal_title：Bulletin of experimental biology and medicine

authors： Dreval' AA,Perminova GI,Kuznetsov NA,Sokolov AA,Laberko LA,Ryzhkova LV

更新日期：2002-04-01 00:00:00

abstract：:Medical histories of 101 urothelial bladder cancer patients were compared with the results of morphological analysis and biomolecular detection of human papilloma viruses (HPV) in the tumor specimens. DNA of HPV16 (the major type of virus responsible for appearance of cervical carcinoma) was detected in 38 specimens, ...

journal_title：Bulletin of experimental biology and medicine

authors： Golovina DA,Ermilova VD,Zavalishina LE,Andreeva YY,Matveev VB,Frank GA,Volgareva GM

更新日期：2016-05-01 00:00:00

abstract：:The morphology of neural and glial cells in different cerebral areas and in various experimental models was quantitatively studied by methods of computer morphometry combined with video image analysis systems. The following parameters were obtained: density of neurons and glial cells per 1 mm(2), number of satellite p...

journal_title：Bulletin of experimental biology and medicine

authors： Khudoerkov RM,Voronkov DN

更新日期：2010-07-01 00:00:00

abstract：:Total antioxidant activity of the serum in patients with liver pathology was assessed by two chemiluminescent methods based on different models of free radical oxidation: Hb-H2O2-luminol and ABAP-luminol. Comparative analysis showed a significant, but not high correlation of the results (r=0.798), which can be explain...

journal_title：Bulletin of experimental biology and medicine

authors： Titov VN,Sazhina NN

更新日期：2014-12-01 00:00:00

abstract：:We studied the reaction of the microglia of the anterior horns of the rat spinal cord to intraperitoneal administration of bacterial LPS. Immunohistochemical analysis showed that acute systemic inflammation leads to activation of more than half of microglial cells as soon as in 24 h after LPS injection, while the tota...

journal_title：Bulletin of experimental biology and medicine

authors： Kolos EA,Korzhevskii DE

更新日期：2017-08-01 00:00:00

abstract：:Lyzed epimastigotes of Trypanosoma cruzi clones P209-1, Gamba1, Sp104-1, MASu, Y7/1, MN12, Cl-Brener, 86/2036, Y7/2-1 inhibit the growth of Ehrlich adenocarcinoma in mice. the tumor decreased 1.5-3 times after 12 daily injections of lysates from 15 million epimastigotes. The protective effect progressed after the inje...

journal_title：Bulletin of experimental biology and medicine

authors： Batmonkh Z,Kallinikova VD,Pakhorukova LV,Kravtsov EG,Karpenko LP,Dalin MV

更新日期：2006-10-01 00:00:00

abstract：:We studied the effect of bone marrow Thy 1,2+ cells on the growth of erythroid colonies and the role of monoamine in the regulation of proliferation and differentiation of erythroid precursor cells in experimental neuroses. Under conditions of conflict situation Thy 1,2+ cells stimulated the growth of erythropoietic p...

journal_title：Bulletin of experimental biology and medicine

authors： Skurikhin EG,Provalova NV,Pershina OV,Minakova MY

更新日期：2005-11-01 00:00:00

abstract：:Fifty-six primary neuroendocrine lung tumors were examined morphologically and histologically and their apoptosis level was determined. Malignant carcinomas were characterized by increased apoptotic index and enhanced expression ofBcl-2, Bak, p53, and Ki-67 compared to typical carcinoid. However, apoptosis in these tu...

journal_title：Bulletin of experimental biology and medicine

authors： Pal'tsev MA,Demura SA,Kogan EA,Jaques G,Zende B

更新日期：2000-07-01 00:00:00

abstract：:Formation of Ala-Glu-Asp-Gly peptide complex with duplex DNA [poly(dA-dT):poly(dA-dT)] at neutral pH and ambient temperature was studied experimentally. Peptide binding to duplex DNA was associated with hyperchromic effect indicating local separation of the double helix. Energies of paired interactions between amino a...

journal_title：Bulletin of experimental biology and medicine

authors： Khavinson VKh,Solovyov AY,Shataeva LK

更新日期：2006-04-01 00:00:00

abstract：:Female rats were exposed to local γ-irradiation of the right hindpaw in doses of 30-50 Gy at 131-154 sGy/min dose rate. Radioprotector indralin was administered per os 15 min prior to irradiation, monizol was injected intraperitoneally 5 min after irradiation. Indralin showed marked radioprotective properties both for...

journal_title：Bulletin of experimental biology and medicine

authors： Vasin MV,Ushakov IB,Kovtun VY,Semenova LA,Komarova SN,Galkin AA,Afanas'ev RV

更新日期：2015-10-01 00:00:00

abstract：:Antileprosy activity of dialkyldithiocarbamate derivatives was studied in experiments on mice infected with M. leprae into paw pads. We found that 2-diethyldithiocarbamoyl-3-cyano-5-nitropyridine is the most promising antileprosy agent; it effectively suppresses multiplication of M. leprae and is well tolerated under ...

journal_title：Bulletin of experimental biology and medicine

authors： Urlyapova NG,Yuschenko AA,Daudova AD,Makarov VA

更新日期：2008-04-01 00:00:00

abstract：:Preclinical study of therapeutic properties of an innovative drug Doxorubicin-NPh (doxorubicin in the form of ultrafine suspension of phospholipid liposomes) in comparison with free doxorubicin (Doxorubicin-Teva) and protected doxorubicin (Caelyx) was performed on transplanted murine tumor models. All these drugs were...

journal_title：Bulletin of experimental biology and medicine

authors： Nemtsova ER,Tikhonova EG,Bezborodova OA,Pankratov AA,Venediktova JB,Korotkevich EI,Kostryukova LV,Tereshkina JA

更新日期：2020-10-01 00:00:00

abstract：:Nadcin in a dose of 90 mg/kg administered to dogs with subacute stage of ischemia-reperfusion myocardial injury immediately after blood flow resumption normalized redox potential of cardiomyocytes and mitochondria and restored the total content of adenyl and pyridine nucleotides. The decrease in the synthesis of ATP a...

journal_title：Bulletin of experimental biology and medicine

authors： Sukoyan GV,Kavadze IK

更新日期：2008-09-01 00:00:00

abstract：:Monoamine metabolism in the hypothalamus and striatum of BALB/c and C57Bl/6 mice (intact and stressed in the open field test) was studied using single- and multidimensional statistical methods. It is suggested that the revealed difference in neurotransmitter metabolism is associated with genetically controlled behavio...

journal_title：Bulletin of experimental biology and medicine

authors： Seredenin SB,Lapitskaya AS,Nadorov SA,Kudrin VS,Badyshtov BA

更新日期：2000-05-01 00:00:00

abstract：:The study examined maturation of preovulatory germinal vesicles oocytes (GV oocytes) induced by gonadotropic hormone PMSG in the inbred C57Bl/6J mice (viewed as a gold standard for diverse biomedical studies) as well as in the first generation hybrid C57Bl/6J×СВА/lac and СВА/lac×C57Bl/6J mice at various ages. The most...

journal_title：Bulletin of experimental biology and medicine

authors： Riabukha YA,Petrova DA,Zatsepina OV

更新日期：2019-09-01 00:00:00

abstract：:We studied the effect of four conjugated synthetic derivatives of estrone and ethynylestradiol and bis-beta-chloroethylamine-containing substance on activity of plasma membrane enzymes 5'-nucleotidase and N+-K+-ATPase. As differentiated from precursors, estrogen cytostatics decreased activity of plasma membrane enzyme...

journal_title：Bulletin of experimental biology and medicine

authors： Mayatskaya EE,Semeikin AV,Rzheznikov VM,Shimanovskii NL

更新日期：2003-12-01 00:00:00

abstract：:The degree of oxygen consumption in rats was determined after intraperitoneal injection of morphine in a single dose of 5 mg/kg. Some animals were injected with morphine and perorally received morphine or antibodies to mu-opiate receptors in ultralow doses obtained by the technology of potentiation. Potentiated substa...

journal_title：Bulletin of experimental biology and medicine

authors： Pavlov IF,Epstein OI

更新日期：2003-01-01 00:00:00

abstract：:In biopsy specimens of the gastric and duodenal mucosa from patients with psoriasis we revealed severe degenerative and dystrophic changes in cells of the surface and glandular epithelium with destruction of functionally important cytoplasmic organelles. The stroma of the gastric mucosa was characterized by hyperplasi...

journal_title：Bulletin of experimental biology and medicine

authors： Khardikova SA,Nepomnyashchikh GI,Aidagulova SV,Lapii GA

更新日期：2002-11-01 00:00:00

abstract：:An integrative systemic model of pharmacological reaction to a phytopreparation was created as a result of conceptual structurization of facts and formalization of causal relations. The use of the new methodological approach to the choice, primary screening, and profound studies of plants for prospective addition ther...

journal_title：Bulletin of experimental biology and medicine

authors： Mitrofanova IY,Yanitskaya AV,Butenko DV

更新日期：2013-09-01 00:00:00

abstract：:The safety of combined administration of ultralow doses of antigens to endothelial NO synthase (impaza) and nitrates for the treatment of erectile dysfunction in CHD patients was evaluated in an open non-comparative clinical trial. The efficiency and safety of impaza and the possibility of its administration to patien...

journal_title：Bulletin of experimental biology and medicine

authors： Zhavbert ES,Kachanova MV,Tarasov SA,Dugina YL,Sergeeva SA,Dovgalevskii PY,Epshtein OI

更新日期：2009-08-01 00:00:00

abstract：:The effects of fullerene C(60) nanocomposites on human platelet aggregation induced by ADP, ristocetin, and collagen were studied. The nanocomposite containing fullerene C(60) in polyvinyl pyrrolidone solution did not change platelet aggregation, while fullerene C(60) in crown ether and Twin-80 solutions inhibited ADP...

journal_title：Bulletin of experimental biology and medicine

authors： Vaschenko VI,Samonin VV,Popov VA,Antonenkova EV,Nikonova VJ,Vilyaninov VN,Podvjaznikov ML,Kidalov VN,Titulova TB,Vaschenko TN

更新日期：2012-03-01 00:00:00

abstract：:Studies of the effects of Trichoderma harzianum Rifai F-180 culture fluid concentrate containing L-lysine-α-oxidase antitumor enzyme produced by the fungus and the homogenous enzyme, on ultrahazardous bacterium Acidovorax citrulli demonstrated the antibacterial activity of the concentrate. Trichoderma harzianum Rifai ...

journal_title：Bulletin of experimental biology and medicine

authors： Smirnova IP,Karimova EV,Shneider YA,Volina EG

更新日期：2018-03-01 00:00:00

abstract：:Angiogenic action of compound GK-2, a dimeric dipeptide mimetic of loop 4 of nerve growth factor (NGF), was studied in in vitro and in vivo experiments. Experiments on human endothelial cell culture HUVEC showed that compound GK-2 significantly (p<0.05) stimulated the initial stage of angiogenesis, and its angiogenic ...

journal_title：Bulletin of experimental biology and medicine

authors： Kryzhanovskii SA,Antipova TA,Tsorin IB,Pekeldina ES,Stolyaruk VN,Nikolaev SV,Sorokina AV,Gudasheva TA,Seredenin SB

更新日期：2016-08-01 00:00:00

abstract：:We analyzed the dynamics of neuropathic pain development and changes in catalase and superoxide dismutase (SOD) activities in the brain, liver, and skeletal muscles of male Wistar rats with 1-month streptozotocin-induced diabetes mellitus. A decrease in mechanical nociceptive threshold was revealed that progressed dur...

journal_title：Bulletin of experimental biology and medicine

authors： Shipilov VN,Chistyakova OV,Trost AM

更新日期：2016-05-01 00:00:00

abstract：:Changes in the amplitude and dynamic parameters of purposive saccades were studied in monkeys with MPTP-induced Parkinson-like syndrome. Lengthening of saccade latency, decreased maximum velocity of eye movements, and impaired saccade accuracy were observed at the early stages MPTP-syndrome. Different disturbances of ...

journal_title：Bulletin of experimental biology and medicine

authors： Tereshchenko LV,Yudin AG,Kuznetsov Y,Latanov AV,Shul'govskii VV

更新日期：2002-02-01 00:00:00

abstract：:The concentration of N-nitrosamines (N-nitrosodimethylamine and N-nitrosodiethylamine) was measured in blood samples from children after consumption of drinking water with high content of nitrates (main group) or water meeting health standards (reference group). N-nitrosodimethylamine level in the blood from children ...

journal_title：Bulletin of experimental biology and medicine

authors： Zaitseva NV,Ulanova TS,Dolgikh OV,Nurislamova TV,Mal'tseva OA

更新日期：2018-01-01 00:00:00

abstract：:Paclitaxel in a single MTD of 40 mg/kg caused chromosome aberrations and genome changes (polyploidy) in the bone marrow cells of mice early and 3 months after the injection. The quantity of early precursors of erythropoiesis in the bone marrow decreased, as did their proliferative potential irrespective of the animal ...

journal_title：Bulletin of experimental biology and medicine

authors： Neupokoeva OV,Fedorova EP,Stavrova LA,Voronova OL,Sandrikina LA,Filonova MV,Churin AA

更新日期：2020-05-01 00:00:00

abstract：:Myocardial remodeling in SHR rats with age-related hypertrophy was characterized by elimination of cardiomyocytes, their hypertrophy, and marked increase in the volume of the connective tissue. The count of cardiomyocytes with contracture injuries and subsegmental contractures increased, and pronounced perivascular an...

journal_title：Bulletin of experimental biology and medicine

authors： Lushnikova EL,Nepomnyashchikh LM

更新日期：2003-02-01 00:00:00

abstract：:Using rat model of experimental sarcoma M-1 we studied the efficacy of photodynamic therapy with boronated chlorine as a photosensitizer in doses of 1.25, 2.5, 5.0, and 10.0 mg/ kg body weight. Laser irradiation was performed at energy densities of 150, 300 J/cm(2) and power density of 0.25 and 0.42 W/cm(2). Treatment...

journal_title：Bulletin of experimental biology and medicine

authors： Kaplan MA,Ol'shevskaya VA,Osipchuk YS,Nikitina RG,Kalinin VN

更新日期：2014-05-01 00:00:00

abstract：:We revealed a significant positive correlation between the concentrations of tissue VEGF and its receptor VEGFR2 in the primary tumor. The degree and direction of changes in the content of VEGF and VEGFR2 in cytosols of tumors from patients with locally spread breast cancer during the preoperation therapy depended on ...

journal_title：Bulletin of experimental biology and medicine

authors： Kim EA,Gershtein ES,Vysotskaya IV,Kushlinskii NE

更新日期：2008-02-01 00:00:00