Abstract：
:hyperthermia caused hemodynamic disorders in the liver and degenerative and necrobiotic changes in hepatocytes of CBA mice. Total hepatocyte count decreased during restitution, this decrease being most pronounced 30 min after exposure. The number of binucleated cells also markedly decreased. The absence of necrotic changes in hepatocytes during the entire restitution period indicated their apoptotic death and elimination by macrophagal resorption. Under these conditions liver regeneration at the cellular level occured mainly via division of binucleated hepatocytes. On the other hand, proliferation of oval cells in the portal zones and their differentiation into hepatocytes were observed at certain stages of reparative regeneration of the liver.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Molodykh OP,Nepomnyashchikh LM,Lushnikova EL,Klinnikova MGsubject
Has Abstractpub_date
2000-09-01 00:00:00pages
912-6issue
9eissn
0007-4888issn
1573-8221journal_volume
130pub_type
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