Abstract:
:Newborn rats received intraperitoneal injections of endothelin-1 in a daily dose of 5 x 10(-8)mol/kg 30 min after administration of NG-nitro-L-arginine methyl ester (9.3 x 10(-5)mol/kg intraperitoneally) from the 2nd to 6th day of life. NADPH diaphorase activity in epithelial and smooth muscle cells of the tracheobronchial system increased 24 h after the last treatment. In this period DNA synthesis underwent opposite changes, which included the inhibition of epithelial cell proliferation and stimulation of smooth muscle cell division. Intensification of free radical oxidation in the lung tissue was accompanied by inactivation of the antioxidant system.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Lebed'ko OA,Timoshin SS,Tsygankov VIdoi
10.1023/a:1015826415361subject
Has Abstractpub_date
2002-03-01 00:00:00pages
239-42issue
3eissn
0007-4888issn
1573-8221journal_volume
133pub_type
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