Effects of endothelin-1 on DNA synthesis and NADPH diaphorase activity in epithelial and smooth muscle cells of the tracheobronchial system in newborn albino rats after repeated treatment with NG-nitro-L-arginine methyl ester.

Abstract:

:Newborn rats received intraperitoneal injections of endothelin-1 in a daily dose of 5 x 10(-8)mol/kg 30 min after administration of NG-nitro-L-arginine methyl ester (9.3 x 10(-5)mol/kg intraperitoneally) from the 2nd to 6th day of life. NADPH diaphorase activity in epithelial and smooth muscle cells of the tracheobronchial system increased 24 h after the last treatment. In this period DNA synthesis underwent opposite changes, which included the inhibition of epithelial cell proliferation and stimulation of smooth muscle cell division. Intensification of free radical oxidation in the lung tissue was accompanied by inactivation of the antioxidant system.

journal_name

Bull Exp Biol Med

authors

Lebed'ko OA,Timoshin SS,Tsygankov VI

doi

10.1023/a:1015826415361

subject

Has Abstract

pub_date

2002-03-01 00:00:00

pages

239-42

issue

3

eissn

0007-4888

issn

1573-8221

journal_volume

133

pub_type

杂志文章
  • Role of humoral factors in the regulation of hemopoiesis during cytostatic-induced myelosuppression.

    abstract::The content of hemopoietic precursors in the bone marrow, its morphological composition, production of hemopoietic growth factors by cells of the hemopoietic microenvironment, erythropoietic activity, and plasma content of endogenous erythropoietin were studied in CBA/CaLac mice with hypoplasia of hemopoiesis induced ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/a:1025469000276

    authors: Dygai AM,Zhdanov VV,Simanina EV,Gur'yantseva LA,Udut EV,Khrichkova TY,Kirienkova EV,Epstein OI,Gol'dberg ED

    更新日期:2003-06-01 00:00:00

  • Method of Surgical Treatment of Spine Injury with the Use of Extracorporeal Navigation System Based on Additive Technologies.

    abstract::We present a method of minimally invasive transcutaneous insertion of screws using a prefabricated extracorporeal navigation system using additive technologies (based on primary data obtained from the DICOM package in multi-detector computed tomography of the affected spine segment) according to the principle of perso...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-020-04810-z

    authors: Dotsenko IA,Kotomtsev VV,Medvinsky ID,Chertkov AK,Saveliev AV

    更新日期:2020-04-01 00:00:00

  • Photodynamic therapy of experimental sarcoma M-1 with boronated chlorine as a photosensitizer.

    abstract::Using rat model of experimental sarcoma M-1 we studied the efficacy of photodynamic therapy with boronated chlorine as a photosensitizer in doses of 1.25, 2.5, 5.0, and 10.0 mg/ kg body weight. Laser irradiation was performed at energy densities of 150, 300 J/cm(2) and power density of 0.25 and 0.42 W/cm(2). Treatment...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-014-2495-z

    authors: Kaplan MA,Ol'shevskaya VA,Osipchuk YS,Nikitina RG,Kalinin VN

    更新日期:2014-05-01 00:00:00

  • Role of JNK and Contribution of p53 to the Realization of the Growth Potential of Mesenchymal Precursor Cells under the Effect of Fibroblast Growth Factor.

    abstract::The role of JNK-mediated signal pathway and participation of p53 transcription factor in stimulation of mesenchymal precursor cell function by the fibroblast growth factor was studied. The levels of fibroblast colony- and cluster formation and proliferative activity of mesenchymal precursors increased in response to J...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-015-2997-3

    authors: Zyuz'kov GN,Zhdanov VV,Udut EV,Miroshnichenko LA,Khrichkova TY,Danilets MG,Simanina EV,Chaikovskii AV,Agafonov VI,Sherstoboev EY,Minakova MY,Burmina YV,Udut VV,Dygai AM

    更新日期:2015-08-01 00:00:00

  • Mechanisms underlying combined action of clonidine and local anesthetics.

    abstract::We studied the mechanisms of combined action of clonidine and local anesthetics amethocaine and imidazo-benzimidazole derivative RU-1117. In contrast to amethocaine, RU-1117 in therapeutic concentrations binds to imidazoline receptors and, to a lesser extent, to alpha(2A)-adrenoceptors on human platelets. Clonidine an...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/a:1026088813307

    authors: Ponomarev VP,Galenko-Yaroshevskii AP,Dukhanin AS,Anisimova VA

    更新日期:2003-07-01 00:00:00

  • Interaction between different parts of the autonomic nervous system in the regulation of smooth muscles in the femoral artery and trachea.

    abstract::We studied the interaction between the sympathetic and parasympathetic parts of the autonomic nervous system in the regulation of smooth muscles in the femoral artery and trachea. It was shown that this regulation involves ganglionic serotoninergic neurons transmitting excitation to 5-HT, receptors in the effector tis...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-006-0078-3

    authors: Lazebnik LB,Lychkova AE

    更新日期:2006-01-01 00:00:00

  • Blood flow in the testes and epididymides of male rats with experimental blockade of testicular veins.

    abstract::Blood flow in reproductive organs was studied during experimental cessation of blood outflow in the testicular vein. This pathological state was accompanied by disturbances of the complex pathogenesis. The major component was autoregulatory focal ischemia, which resulted from the venoarterial response to venous hypert...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-007-0213-9

    authors: Artifeksov SB,Artyukhin AA

    更新日期:2007-06-01 00:00:00

  • Neurological Deficit and Structural Changes in Lymphoid Structures of the Tracheal Wall in the Immediate Stage of Experimental Hemorrhagic Stroke in Rats with Different Behavioral Activity.

    abstract::Specific features of neurological deficit and changes in the cellular composition of tracheal lymphoid structures during the immediate stage (day 1) of hemorrhagic stroke were studied in rats with various behavioral parameters. Modeling of hemorrhage in the left caudate nucleus of the brain was followed by the develop...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-019-04424-0

    authors: Klyueva LV,Koplik EV,Vasyanina KA,Pertsov SS

    更新日期:2019-04-01 00:00:00

  • Immunotropic effects of hexavalent chromium soluble compounds on the thymus and peripheral blood values in a subacute experiment.

    abstract::Intraperitoneal injections of hexavalent chromium (sodium bichromate) in the concentrations of 0.025 μg/kg (10-fold lower than MAC; group 1) and 2.5 μg/kg (10-fold higher than MAC; group 2) to rats in a subacute experiment caused dose-dependent morphological changes in the thymus: increased the counts of cells in a st...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-014-2387-2

    authors: Zhumabaeva AN,Zarishnyak NV,Bekmukhambetov EZh

    更新日期:2014-02-01 00:00:00

  • Structural changes in abdominal aorta and vena cava inferior after experimental microwave destruction.

    abstract::We studied morphological changes in rat abdominal aorta and vena cava inferior induced by endovascular microwave destruction. This treatment induced thrombosis and necrosis of the vascular walls, but fibrous framework was not completely destroyed. Then we observed irreversible changes in vessels: obliteration, atrophy...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/a:1020633427502

    authors: Denisov-Nikol'skii YI,Shafranov VV,Borkhunova EN,Doktorov AA,Mikhaleva LM,Mikhalev AP

    更新日期:2002-07-01 00:00:00

  • Effect of ascovertin on morphological changes in rat retina exposed to high-intensity light.

    abstract::Experiments on rats showed that high-intensity light exposure (6000 lux, 6 h) caused focal injuries in the retina. The most sensitive structures were neurosensory cells, pigmented epithelium, radial gliocytes, and choroid capillaries. Injection of ascovertin led to disappearance of foci of injuries, limited blood supp...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-006-0029-z

    authors: Logvinov SV,Plotnikov MB,Varakuta EY,Zhdankina AA,Potapov AV,Mikhulya EP

    更新日期:2005-11-01 00:00:00

  • Local Treatment of Local Staphylococcal Infection with Complex Preparations Based on Metal Nanoparticles in the Experiment.

    abstract::Antibacterial activity of powdered preparations based on copper and silver nanoparticles was compared with activity of the reference preparation Baneocin on the model of local staphylococcal infection in white rats. The developed preparations exhibited pronounced antibacterial activity against methicillin-resistant S....

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-019-04622-w

    authors: Babushkina IV,Mamonova IA,Ulyanov VY

    更新日期:2019-10-01 00:00:00

  • Inhibition of thrombin activity with DNA-aptamers.

    abstract::The effects of two DNA aptamers (oligonucleotides) 15TBA and 31TBA (15- and 31-mer thrombin-binding aptamers, respectively) on thrombin activity were studied. Both aptamers added to human plasma dose-dependently increased thrombin time (fibrin formation upon exposure to exogenous thrombin), prothrombin time (clotting ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-009-0627-7

    authors: Dobrovolsky AB,Titaeva EV,Khaspekova SG,Spiridonova VA,Kopylov AM,Mazurov AV

    更新日期:2009-07-01 00:00:00

  • Effects of Thermoextracts of Brucella S and L Forms on Lipid Peroxidation and Antioxidant Defense in Organs of Laboratory Animals.

    abstract::The dynamics of LPO marker malondialdehyde formation and peroxidase-destroying activity was studied in homogenized organs of guinea pigs, immunized with thermoextracts from S and L forms Brucella abortus I-206. The L form brucella thermoextract exhibited a lower reactogenicity and adequately activated the antioxidant ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-018-4138-2

    authors: Dubrovina VI,Balakhonov SV,Yurieva OV,Starovoitova TP,Barannikova NL,Tokareva LE,Pyatidesyatnikova AB,Yastremskaya KY,Shkaruba TT

    更新日期:2018-06-01 00:00:00

  • Comparative effect of amphetamine and caffeine on spontaneous activity of sensomotor cortical units and their responses to stimulation of the caudate nucleus.

    abstract::In acute experiments on anesthetized cats activity of sensomotor cortical units was recorded during low-frequency stimulation of the head of the caudate nucleus. Amphetamine (1 mg/kg), although not significantly affecting the spontaneous firing rate, increased the number of spontaneously active cortical units. Meanwhi...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/BF00799317

    authors: Arushanyan EB,Belozertsev YA,Aivazov KG

    更新日期:1975-01-01 00:00:00

  • Morphological changes in immune and endocrine organs of mice injected with a gonadotropin-releasing hormone analog.

    abstract::Infection of surfagon (gonadotropin-releasing hormone analog) in a dose of 0.1 microg/kg to male CBA mice stimulated lymphocyte migration from splenic B zones, caused moderate thinning of the thymic cortex, thickening of the zona fasciculata of the adrenal cortex with signs of corticocyte activation. After administrat...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-005-0225-2

    authors: Bobyntsev II,Dolzhikov AA,Severyanova LA

    更新日期:2005-01-01 00:00:00

  • Association of Polymorphisms in Innate Immunity Genes TLR9 and DEFB1 with Human Longevity.

    abstract::The distribution of polymorphic variants of innate immunity genes TLR9 (+2848G>A) and DEFB1(-20G>A; -44C>G; -52G>A) was evaluated in long-living individuals. No significant differences were found in the distribution of genotypes and alleles of the TLR9 gene. The following features were revealed: increase in the freque...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-015-2894-9

    authors: Gankovskaya LV,Svitich OA,Artem'eva OV,Miroshnichenkova AM,Rusanova KV

    更新日期:2015-05-01 00:00:00

  • Estimation of Functional Activity of Ionized Calcium for Complement System Reactivity Assessment.

    abstract::We proposed a new indicator for evaluation of functional activity of Ca(2+) in human blood serum based on lysis of sheep erythrocytes with 10% human blood serum in the presence of 0.55 mM ethylene glycol tetraacetic acid at 37°C for 10 min. After incubation, the degree of sheep erythrocytes lysis inhibition is estimat...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-015-2948-z

    authors: Shoibonov BB,Grigor'eva DV,Shabalina AA,Kostyreva MV,Baronets VY,Zamolodchikova TS

    更新日期:2015-07-01 00:00:00

  • Poly(ADP-ribose)-polymerase-1 and aging: experimental study of possible relationship on stationary cell cultures.

    abstract::Experiments on "stationary aging" cultures of B11dii-FAF28 Chinese hamster cells showed that contact inhibition of cell growth and further culturing of cells in the stationary phase led to continuous inhibition of enzymes realizing poly-ADP-ribosylation of chromatin proteins. Cell density in the monolayer and percenta...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-006-0238-5

    authors: Shram SI,Shilovskii GA,Khokhlov AN

    更新日期:2006-05-01 00:00:00

  • Autofluorescence of low-density lipoproteins modified as a result of autooxidation.

    abstract::Autooxidation of low-density lipoproteins during incubation at 37 degrees C was accompanied by accumulation of LPO products, decrease in UV autofluorescence (FUV), and increase in autofluorescence in the visible band (FVIS). The degree of low-density lipoprotein modification was estimated by calculating the FVIS/FUV r...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-006-0385-8

    authors: Aidyraliev RK,Azizova OA,Vakhrusheva TV,Lopukhin YM,Mirrakhimov MM

    更新日期:2006-10-01 00:00:00

  • Soft Tissue Regeneration under the Effect of Wound Coating Based on Chitosan (Natural Biopolymer).

    abstract::We developed wound coating based on natural biopolymer chitosan with additional components (ceruloplasmin, L-asparaginic acid, and glycerol). Experiments on albino male rats demonstrated its regeneratory, antioxidant, and antibacterial effects on wounds involving all layers of the skin. Due to chemical composition and...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-016-3258-9

    authors: Gladkova EV,Babushkina IV,Norkin IA,Mamonova IA,Puchin'yan DM,Konyuchenko EA

    更新日期:2016-03-01 00:00:00

  • Structural and functional changes in pulmonary macrophages and lungs of mice infected with influenza virus A/H5N1 A/goose/Krasnoozerskoye/627/05.

    abstract::C57Bl/6 mice were intranasally infected with influenza virus A/H5N1 A/goose/Krasnoozerskoye/627/05. The mortality rate of animals reached 70% on day 14 of the disease. The lungs of animals were characterized by necroses, destruction of vessels, hemorrhagic and thrombotic complications, edematous syndrome, and early fi...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-012-1683-y

    authors: Kovner AV,Anikina AG,Potapova OV,Sharkova TV,Cherdanceva LA,Shkurupy VA,Shestopalov AM

    更新日期:2012-06-01 00:00:00

  • Efficiency of trekrezan in experimental bronchopneumonia in rats.

    abstract::Trekrezan in a dose of 25 mg/kg normalized the lymphocyte immune status and produced an energy-stabilizing effect, which manifested in decreased levels of lactate, ADP, and AMP and increased content of pyruvate and ATP in blood lymphocytes and lung tissue of rats with experimental acute bronchopneumonia. ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-006-0328-4

    authors: Zarubina IV,Bolekhan AV,Shabanov PD

    更新日期:2006-08-01 00:00:00

  • Relationship between oxidized fibrinogen and hemostasis disturbances and endothelial dysfunction in myocardial infarction.

    abstract::Oxidative modification of fibrinogen in acute myocardial infarction increased 1.3-fold compared to that in CHD and 1.5-fold surpassed that in the control without CHD. Elevated content of oxidized fibrinogen correlated with increased levels of LPO products, von Willebrand factor, and fibrin degradation products, with a...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-008-0104-8

    authors: Ragino YI,Baum VA,Polonskaya YV,Sadovski EV,Baum SR,Nikitin YP

    更新日期:2008-04-01 00:00:00

  • Peripheral administration of loperamide and methylnaloxone decreases the degree of anxiety in rats.

    abstract::We studied the effect of μ-opioid receptor ligands on anxious and depressive behavior of rats. Intragastric administration of loperamide and methylnaloxone reduced animal anxiety evaluated by an increase in the number of entries into and time spent in open arms of the elevated plus-maze. μ-Opioid receptor agonist lope...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-010-0925-0

    authors: Sudakov SK,Bashkatova VG,Kolpakov AA,Trigub MM

    更新日期:2010-09-01 00:00:00

  • Effect of Bioritm-E phytococktail and experimental medicinal drug from spurdog liver Skvaakan on microcirculation, platelet aggregation, and thromboresistance of vascular wall in rats.

    abstract::The study compared the effects of phytococktail Bioritm-E (a multicomponent phytoadaptogen) and experimental preparation Skvaakan from the liver of Black Sea spurdog on systemic homeostasis, microcirculation, and blood lipid profile in 15 days of their daily administration. Skvaakan enhanced the platelet activity prod...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-012-1917-z

    authors: Datieva FS,Khetagurova LG

    更新日期:2012-12-01 00:00:00

  • Chronotropic and dromotropic components of cardiac reflexes in the cat.

    abstract::The relationship between dromotropic and chronotropic components of various cardiac reflexes was studied in cats. Intravenous infusion of blood was mainly accompanied by unidirectional negative chronotropic and dromotropic effects, but the dynamics of these effects was different. Clumping of the carotid arteries in mo...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-008-0041-6

    authors: Alipov NN,Sergeeva OV,Bobrova NA,Kuznetsova TE,Smirnov VM

    更新日期:2008-02-01 00:00:00

  • Cytokine Profiling of Subclinical Tick-Borne Infections in Humans.

    abstract::Over many years, tick-borne infections remain one of the most serious threats to human health worldwide. The immune response to these infections in a human after confirmed bite by an infected carrier at the early stages of infection in the absence of clinical symptoms can be the first indicator of the presence of the ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-019-04405-3

    authors: Danchinova GA,Khasnatinov MA,Lyapunova NA,Solovarov IS,Manzarova EL,Lyapunov AV,Petrova IV

    更新日期:2019-03-01 00:00:00

  • Effects of a local focus of granulation tissue formed in the bone marrow cavity on reparative osteogenesis.

    abstract::The stimulatory effect of a local focus of granulation tissue, created in the bone marrow cavity, on reparative osteogenesis after tibial bone fracture was detected in experimental rats by microscopic examination of histological sections, scanning electron microscopy, and X-ray electron probe microanalysis. ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-014-2503-3

    authors: Ir'yanov YM,Dyuryagina OV

    更新日期:2014-05-01 00:00:00

  • Effects of Lys-Glu-Trp peptide on cell-cell interactions and vascular endothelium proliferation under normal conditions and during atherosclerosis.

    abstract::The molecular mechanism of atherosclerosis is based on decreased expression of signal molecules connexin (Cx37 and Cx40), vascular endothelial growth factor (VEGF), and proliferative protein Ki-67, which characterize the processes of cell-cell interactions and proliferation of vascular endotheliocytes. Lys-Glu-Trp pep...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-014-2556-3

    authors: Malinin VV,Durnova AO,Polyakova VO,Kvetnoi IM

    更新日期:2014-07-01 00:00:00