Abstract：
:Using rat model of experimental sarcoma M-1 we studied the efficacy of photodynamic therapy with boronated chlorine as a photosensitizer in doses of 1.25, 2.5, 5.0, and 10.0 mg/ kg body weight. Laser irradiation was performed at energy densities of 150, 300 J/cm(2) and power density of 0.25 and 0.42 W/cm(2). Treatment efficacy was evaluated by the percentage of animals with complete tumor regression, percentage of tumor recurrence and, in cases of its growth, by tumor growth coefficient. The efficacy of photodynamic therapy depended on the dose of boronated chlorine and parameters of the laser irradiation. Optimal conditions were the dose of 2.5 mg/kg at laser energy density of 300 J/cm(2) and power density of 0.42 W/cm(2) and a dose of 5.0 mg/kg at 150 J/cm(2) and 0.25 W/cm(2).
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Kaplan MA,Ol'shevskaya VA,Osipchuk YS,Nikitina RG,Kalinin VNdoi
10.1007/s10517-014-2495-zsubject
Has Abstractpub_date
2014-05-01 00:00:00pages
74-6issue
1eissn
0007-4888issn
1573-8221journal_volume
157pub_type
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