Abstract：
:The distribution of polymorphic variants of innate immunity genes TLR9 (+2848G>A) and DEFB1(-20G>A; -44C>G; -52G>A) was evaluated in long-living individuals. No significant differences were found in the distribution of genotypes and alleles of the TLR9 gene. The following features were revealed: increase in the frequency of AA and GG genotypes and decrease in the frequency of the AG genotype of the DEFB1(-20G>A) gene; increase in the frequency of the CC genotype and C allele and decrease in the frequency of CG and GG genotypes and G allele of the DEFB1(44C>G) gene; and increase in the frequency of AA and AG genotypes and A allele and decrease in the frequency of the GG genotypes and G allele of the DEFB1(-52G>A) gene. Genotypes and alleles of the DEFB1 gene found in long-living individuals can be considered as the factors that increase the probability of longevity and favorable course of age-related diseases.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Gankovskaya LV,Svitich OA,Artem'eva OV,Miroshnichenkova AM,Rusanova KVdoi
10.1007/s10517-015-2894-9subject
Has Abstractpub_date
2015-05-01 00:00:00pages
77-80issue
1eissn
0007-4888issn
1573-8221journal_volume
159pub_type
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