Abstract：
:Noopept, a peptide analog of piracetam, enhanced phagocytic activity of mouse peritoneal macrophages, stimulated humoral and cellular immune response to various antigens, and markedly increased spontaneous proliferative activity of splenocytes. In animals with secondary immune deficiency caused by cyclophosphamide, noopept exhibited immunocorrector properties.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Kovalenko LP,Shipaeva EV,Alekseeva SV,Pronin AV,Durnev AD,Gudasheva TA,Ostrovskaja RU,Seredenin SBdoi
10.1007/s10517-007-0251-3subject
Has Abstractpub_date
2007-07-01 00:00:00pages
49-52issue
1eissn
0007-4888issn
1573-8221pii
doijournal_volume
144pub_type
杂志文章abstract：:Influenza virus hemagglutinins are surface proteins responsible for fusion of the viral and cellular membranes. Their capacity to mediate membrane fusion (fusogenic activity) is studied by various methods, including the syncytium formation and pseudovirus transduction methods. We constructed plasmids coding for genes ...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-017-3930-8
更新日期：2017-11-01 00:00:00
abstract：:Structural modifications of the gastric tube transplant were studied during the delayed period after esophagoplasty carried out for benign diseases of the esophagus. Adaptive and pathological reactions manifesting in atrophic and sclerotic changes in the mucosa formed the basis for transplant reorganization. The leadi...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-010-1016-y
更新日期：2010-10-01 00:00:00
abstract：:The local anaphylactic reaction and the effects of histamine during blocking of the slow sodium-calcium channels by isoptine were investigated in the spontaneously contracting oracle of the atrium of a guinea pig previously sensitized to egg albumin. Simultaneously with the intracellular recording of the potentials, i...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/BF00799305
更新日期：1975-01-01 00:00:00
abstract：:The cells isolated from biopsy specimen of a patient with alcoholic liver cirrhosis and cultured under standard conditions for obtaining stromal cell culture clearly diverged during early passages into two morphologically and phenotypically different subtypes: epithelial and mesenchymal. Mesenchymal cells expressed CD...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-016-3559-z
更新日期：2016-11-01 00:00:00
abstract：:Total antioxidant activity of the serum in patients with liver pathology was assessed by two chemiluminescent methods based on different models of free radical oxidation: Hb-H2O2-luminol and ABAP-luminol. Comparative analysis showed a significant, but not high correlation of the results (r=0.798), which can be explain...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-014-2742-3
更新日期：2014-12-01 00:00:00
abstract：:High doses of phenylephrine and diazepam (1 and 10 mg/kg, respectively) suppressed the development of generalized tonic-clonic pentylenetetrazole-induced convulsions in 86-100% rats, but did not prevent local clonic pentylenetetrazole-induced convulsions. Diazepam in the specified dose produced strong sedation, while ...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-014-2730-7
更新日期：2014-12-01 00:00:00
abstract：:Female rats were exposed to local γ-irradiation of the right hindpaw in doses of 30-50 Gy at 131-154 sGy/min dose rate. Radioprotector indralin was administered per os 15 min prior to irradiation, monizol was injected intraperitoneally 5 min after irradiation. Indralin showed marked radioprotective properties both for...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-015-3065-8
更新日期：2015-10-01 00:00:00
abstract：:Tropomyosin (Tpm) is one of the main regulatory proteins in the myocardium. In some heart pathologies, interchain disulfide crosslinking in the Tpm molecule occurs. In the ventricle, this change in the structural properties of the Tpm molecule affects calcium regulation of the actin-myosin interaction. Using an in vit...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-019-04462-8
更新日期：2019-05-01 00:00:00
abstract：:The effects of two derivatives of 2-aminoadamantane, enantiomers J447H and J579, on the behavior of male and female C57Bl/6J mice were studied using a modified light/dark test. The substances differed by their effects on the behavior of male mice. J579 reduced the number of rearings. J447H in a dose of 1 mg/kg affecte...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-014-2725-4
更新日期：2014-12-01 00:00:00
abstract：:Fibroblasts isolated from skin biopsy specimens from patients with genetic forms of Parkinson's disease, carriers of mutations in LRRK2 and PARK2 genes, and from a healthy volunteer were reprogrammed using lentiviral vectors into induced pluripotent stem cells (iPSC). iPSC were differentiated into neuron-like cells us...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-015-3072-9
更新日期：2015-10-01 00:00:00
abstract：:We studied the effect of a biomedical cell product (bone marrow multipotent mesenchymal stromal cells and products secreted by these cells in conditioned medium) on subpopulation composition of lymphoid cells of central and peripheral lymphoid organs of Wistar rats under normal conditions. Changes in the subpopulation...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-016-3366-6
更新日期：2016-05-01 00:00:00
abstract：:A simple method for the diagnosis of insulin resistance, easily realized in clinical practice, is developed in order to detect patients at a high risk of diseases associated with this condition. The metabolic index is estimated as the proportion of triglycerides and glucose values to quadratic HDL cholesterol value (i...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-015-2771-6
更新日期：2015-01-01 00:00:00
abstract：:Multivariate analysis was used to examine the morphology of mixed saliva crystals in 55 healthy men and the patients with suspected malignant prostate gland diseases. The established changes in the shape of dendritic crystals in the saliva from prostate-problematic patients were corroborated by the cluster and discrim...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-006-0338-2
更新日期：2006-08-01 00:00:00
abstract：:We studied the interaction of the oculomotor, cervical, and vestibular systems using a specially developed technique. A series of two tests were performed on 26 healthy subjects and 42 patients with stages I-II Parkinson's disease receiving and not receiving treatment. In coordinated tests, all amplitude-time characte...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-011-1443-4
更新日期：2011-11-01 00:00:00
abstract：:Applications of cold and warm activated cellular immunity and orientation and exploratory behavior in mice. Application of cold increased the number of turns to the left in the open field, muscle force, and activity of the food instinct, and caused an increase in the total count of peripheral blood leukocytes. Warm ap...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-013-2052-1
更新日期：2013-04-01 00:00:00
abstract：:Activities of antioxidant enzymes, vitamin E level, lactate dehydrogenase isoenzyme spectrum, and effects of melatonin on these parameters were studied in the myocardium of rats aged 6, 12, 18, and 24 months exposed to different illumination regimens. The greatest number of changes was recorded in rats exposed to perm...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-010-0945-9
更新日期：2010-09-01 00:00:00
abstract：:High basal production of primary active oxygen forms was detected in the peripheral blood neutrophils of patients with renal cell cancer. In vitro stimulation of neutrophils led to more rapid release of superoxide radicals into extracellular space and to a reduction of cell capacity to more intense production of prima...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-010-0916-1
更新日期：2010-08-01 00:00:00
abstract：:Groups of microRNA genes, methylation of which is associated with the initial (I-II) stages of breast cancer, are determined, and new markers and marker systems for the disease diagnosis were created on the basis of these data. A total of 14 genes in which methylation was associated with breast cancer were identified ...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-019-04691-x
更新日期：2019-12-01 00:00:00
abstract：:We compared the effects of soluble products from the placenta obtained from women with normal pregnancy and pregnancy complicated by preeclampsia on cytokine secretion by THP-1 cells cultured on a 3D Matrigel scaffold. In the presence of soluble products from all placentas, the cells actively secreted IL-8, MCP-1, and...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-014-2397-0
更新日期：2014-02-01 00:00:00
abstract：:Telocytes, a new type of interstitial stem cells with long thin processes that form a three-dimensional network around cardiomyocytes, vessels, and nerve fibers were described in the myocardium of children with tetralogy of Fallot. Two types of morphologically different telocytes, spindle-shaped and rounded, were iden...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-020-04840-7
更新日期：2020-05-01 00:00:00
abstract：:An integrative systemic model of pharmacological reaction to a phytopreparation was created as a result of conceptual structurization of facts and formalization of causal relations. The use of the new methodological approach to the choice, primary screening, and profound studies of plants for prospective addition ther...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-013-2216-z
更新日期：2013-09-01 00:00:00
abstract：:A series of short neurotoxins (molecular weight 3500-5000 D) was isolated from Vietnamese scorpion B. occitanus sp. All these toxins blocked generation of action potentials (this effect depended on their molecular weight), but did not change conduction velocity and excitation threshold of the nerve. ...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1023/a:1013659026064
更新日期：2001-10-01 00:00:00
abstract：:Activity and levels of protein and mRNA of 3-hydroxy-3-methyl-glutaryl-CoA reductase were estimated in rat liver after the administration of atorvastatin and simvastatin and their complexes with glycyrrhizic acid (atorvaglyzin and simvaglyzin). The amount of 3-hydroxy-3-methyl-glutaryl-CoA reductase protein in rats de...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-013-2278-y
更新日期：2013-11-01 00:00:00
abstract：:We studied the content of corticosterone and its precursors in the adrenal glands, corticosterone in blood serum and daily urine of rats, and activity of first and second isoforms of 11β-hydroxysteroid dehydrogenase in the liver and kidneys of rats after 15 daily intraperitoneal injections of 0.9% NaCl or glucocortico...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-016-3390-6
更新日期：2016-06-01 00:00:00
abstract：:We studied the effect of mesenchymal stromal cells and conditioned media on healing of full-thickness skin wound in rats. Cell transplantation to the wound bed did not accelerate wound closing and had no effect on the severity of inflammation, but increased vasculariza - tion of the granulation tissue in 14 days after...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-018-4215-6
更新日期：2018-08-01 00:00:00
abstract：:We studied the effects and mechanisms of action of NaHS, an H2S donor, on isolated phenylephrine-precontracted bovine mesenteric lymph nodes. NaHS induced concentration-dependent relaxation of lymph nodes. Removal of the endothelium reduced, but did not abolish the relaxing effect of NaHS. The relaxing effect was redu...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-020-04848-z
更新日期：2020-06-01 00:00:00
abstract：:We studied regulation of hypoxanthine transport depending on its concentration in the culture medium. Caco-2 cells were differentiated on membrane filters to create a model of the intestine. Different hypoxanthine uptake on the apical and basolateral cell membranes was observed. The expression of SLC29 family genes en...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-015-3118-z
更新日期：2015-11-01 00:00:00
abstract：:Changes in ECG parameters were studied in pregnant rats exposed to acute hypobaric hypoxia during the period of organogenesis (gestation days 9 to 10). Rats with low, medium, and high tolerance to hypoxia exhibited pronounced autonomic nervous system imbalance, which become apparent as a loss of correlation between va...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-005-0241-2
更新日期：2005-02-01 00:00:00
abstract：:Immunosorbent removing beta2-microglobulin from human blood plasma was synthesized on the basis of sheep monospecific polyclonal antibodies to beta2-microglobulin and conditions ensuring effective regeneration of the immunosorbent for its repeated use were selected. Relationships between adsorption capacity and the vo...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1023/a:1013679630607
更新日期：2001-10-01 00:00:00
abstract：:Interleukin-1beta mRNA, interleukin-1beta receptor mRNA, and erythropoietin receptor mRNA are expressed in the brain of (CBAxC57Bl)F1 mice. Immunization with sheep erythrocytes stimulated the expression of these cytokines in the cerebral hemispheres. Injection of recombinant erythropoietin reduced expression of interl...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1023/a:1015112729103
更新日期：2002-01-01 00:00:00
