Abstract：
:The local anaphylactic reaction and the effects of histamine during blocking of the slow sodium-calcium channels by isoptine were investigated in the spontaneously contracting oracle of the atrium of a guinea pig previously sensitized to egg albumin. Simultaneously with the intracellular recording of the potentials, isometric contractions of the preparation were recorded by means of a mechanotron. The investigation showed that egg albumin (0.2 mg/ml) and histamine (0.1 mg/ml) are antagonists of isoptine (2-16 mg/liter) as regards its effect on automatic contraction and duration of the action potential. It is postulated that this anaphylatic reaction is based on activation of the slow sodium-calcium channels in the surface membrane of the myocardial fibers.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Khodorov BI,Voronovitskii EG,Ignat'eva VBdoi
10.1007/BF00799305subject
Has Abstractpub_date
1975-01-01 00:00:00pages
741-4issue
7eissn
0007-4888issn
1573-8221journal_volume
77pub_type
杂志文章abstract：:The effects of intramuscular administration of neostigmine and physostigmine on Na+,K+-ATPase activity in various cerebral subdivisions were examined in rats. In CNS and peripheral tissues, both agents rapidly and significantly reduced activity of cholinesterases by 30-50%. The development of intoxication did not chan...
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