Abstract:
:Tropomyosin (Tpm) is one of the main regulatory proteins in the myocardium. In some heart pathologies, interchain disulfide crosslinking in the Tpm molecule occurs. In the ventricle, this change in the structural properties of the Tpm molecule affects calcium regulation of the actin-myosin interaction. Using an in vitro motility assay, we found that Tpm crosslinking does not affect the actin-myosin interaction in the atria. We assume that the intramolecular crosslinking of Tpm in the atrium does not play such a crucial role in the pathogenesis of heart failure as it plays in the heart ventricles.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Shchepkin DV,Matyushenko AM,Bershitsky SY,Kopylova GVdoi
10.1007/s10517-019-04462-8subject
Has Abstractpub_date
2019-05-01 00:00:00pages
65-68issue
1eissn
0007-4888issn
1573-8221pii
10.1007/s10517-019-04462-8journal_volume
167pub_type
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