Effects of short-term local warm and cold applications to the chest on immunophysiological parameters of the organism.

abstract：:Effect of the dipeptidyl peptidase-4 inhibitor linagliptin on structural manifestations of diabetic nephropathy was studied in BKS.Cg-Dock7m+/+Leprdb/J mice (experimental model of type 2 diabetes mellitus). Linagliptin (10 mg/kg per day) or vehicle was administered by gavage over 8 weeks. Mesangial expansion, thickeni...

journal_title：Bulletin of experimental biology and medicine

authors： Gavrilova YS,Bgatova NP,Klimontov VV,Ischenko IY,Michurina SV,Myakina NE,Zavyalov EL

更新日期：2016-08-01 00:00:00

abstract：:The effect of melanin solutions on the skin exposed to UV irradiation (1,050 kJ/m(2)) depended on its dose and varied from photoprotection (0.005 mg/ml) to photosensitization and phototoxicity (burn, 0.1 mg/ml). These results suggest that doses of melanin preparations should be empirically selected to achieve optimum ...

journal_title：Bulletin of experimental biology and medicine

authors： Paramonov BA,Turkovskii II,Potokin IL,Chebotarev VY

更新日期：2002-04-01 00:00:00

abstract：:Biopsy specimens from patients with psoriasis treated with antiproliferative drugs (methotrexate, etretinate) were analyzed. Acanthosis and papillomatosis of the epidermis and inflammatory reaction of the derma decreased. A tendency to normalization of epidermocyte ultrastructure with regeneration of tonofilaments and...

journal_title：Bulletin of experimental biology and medicine

authors： Krinitsyna YM,Nepomnyashchikh GI,Aidagulova SV

更新日期：2001-08-01 00:00:00

abstract：:We studied the effects of lithium carbonate on the cell cycle, apoptosis, and autophagy in hepatocellular carcinoma-29 cells (HCC-29) in vitro. Flow cytofluorometry analysis revealed accumulation of G2/M-phase HCC-29 cells and increase in the number of apoptotic cells in 48 h after administration of 5 mM lithium carbo...

journal_title：Bulletin of experimental biology and medicine

authors： Taskaeva YS,Bgatova NP,Dossymbekova RS,Solovieva AO,Miroshnichenko SM,Sharipov KO,Tungushbaeva ZB

更新日期：2020-12-01 00:00:00

abstract：:In the myocardium and skeletal muscles of rats deprived of food for 2 days, basal activity of adenylate cyclase decreased, while the sensitivity of adenylate cyclase signaling system to the stimulating effects of non-hormonal agents (guanine nucleotides and NaF) and beta-agonist isoproterinol modulating adenylate cycl...

journal_title：Bulletin of experimental biology and medicine

authors： Shpakov AO,Kuznetsova LA,Plesneva SA,Pertseva MN

更新日期：2007-07-01 00:00:00

abstract：:Serum concentration of copper, immunoreactive polypeptides of ceruloplasmin and its oxidase activity, and the number of copper atoms per ceruloplasmin molecule were decreased in patients with Parkinson's disease in comparison with the corresponding parameters in age-matched healthy individuals, but the ratio of apocer...

journal_title：Bulletin of experimental biology and medicine

authors： Karpenko MN,Ilyicheva EY,Muruzheva ZM,Milyukhina IV,Orlov YA,Puchkova LV

更新日期：2018-03-01 00:00:00

abstract：:Effects of local therapy with miacalcic on the metabolism in articular connective tissue structures under conditions of experimental arthritis are shown. An effect modifying articular tissue metabolism and an antiinflammatory effect preventing the development of inflammatory destructive processes in rabbit articular t...

journal_title：Bulletin of experimental biology and medicine

authors： Belova SV

更新日期：2007-03-01 00:00:00

abstract：:The possibility of local laser destruction of the trigeminal sensory root by a puncture technique is demonstrated. A fibrous scar was formed on a limited area of the trigeminal root. There were no signs of axonal regeneration, posttraumatic neuroma, or considerable changes in the Meckel sinus. ...

journal_title：Bulletin of experimental biology and medicine

authors： Giniatullin RU,Kozel' AI,Ismagilova ST

更新日期：2000-06-01 00:00:00

abstract：:The immunomodulatory properties of immunobiological drugs Glutoxim and Phosprenyl we well as vesicular stomatitis virus and inactivated tick-borne encephalitis vaccine virus were studied using human diploid fibroblast cell line from the collection of M. P. Chumakov Federal Research Center for Research and Development ...

journal_title：Bulletin of experimental biology and medicine

authors： Konyuschko OI,Ozherelkov SV,Vorovich MF,Ivanova AL,Sotskova SE,Ishmuhametov AA,Kozhevnikova TN,Sanin AV

更新日期：2020-12-01 00:00:00

abstract：:Addition of anaferon (pediatric formulation) to the therapy of chickenpox patients led to more rapid disappearance of the main symptoms and alleviated the course of the disease. The safety of the preparation is confirmed by the absence of undesirable events and stability of laboratory indexes against the background of...

journal_title：Bulletin of experimental biology and medicine

authors： Timchenko VN,Pavlova EB,Chernova TM,Bannova SL,Savel'eva TI,Tarasov SA,Kachanova MV,Siver'yanova MA

更新日期：2009-08-01 00:00:00

abstract：:Acute experiments on cats showed that dynorphin A(1-13) modulates pulse activity of afferent neurons and interneurons in the bulbar cardiovascular center against the background of stable blood pressure. ...

journal_title：Bulletin of experimental biology and medicine

authors： Mikhailova SD,Vasil'eva TV,Semushkina TM,Storozhakov GI

更新日期：2003-01-01 00:00:00

abstract：:Induction of direct cell death is one of the mechanisms of the antitumor effect of GD2-specific antibodies used for the therapy of high-risk neuroblastoma. The mechanisms of the cytotoxic signal triggered by antibody binding to GD2 ganglioside on the surface of the tumor cell remain insufficiently studied. Using inhib...

journal_title：Bulletin of experimental biology and medicine

authors： Doronin II,Kholodenko IV,Zubareva AA,Yarygin KN,Deev SM,Kholodenko RV

更新日期：2019-02-01 00:00:00

abstract：:The effect of Dicarbamin preparation on hemopoiesis suppressed with cyclophosphamide was studied in animal experiments. It was shown that Dicarbamin produced a protective effect on granulocytic hemopoietic steam. This property of the preparation is determined by both protection of immature granulocytic cells at early ...

journal_title：Bulletin of experimental biology and medicine

authors： Nebolsin VE,Zhdanov VV,Zyuzkov GN,Udut EV,Khrichkova TY,Simanina EV,Stavrova LA,Miroshnichenko LA,Chaikovskiy AV,Dygai AM

更新日期：2011-01-01 00:00:00

abstract：:Phosphatidylcholine liposomes in a dose of 25 mg/kg displayed wound-healing properties. They increased the count of alveolar macrophages, lymphocytes, and microvessels in damaged regions and, therefore, attenuated emphysematous changes in the lungs. ...

journal_title：Bulletin of experimental biology and medicine

authors： Kornilova ZK,Selishcheva AA,Perel'man MI

更新日期：2001-02-01 00:00:00

abstract：:Modification of apolipoprotein B-100 conformation on the surface of LDL isolated from human blood was demonstrated by enzyme immunoassay with a panel of monoclonal antibodies to this protein. The study by the light transmission fluctuation method showed that incubation of LDL with phospholipases A2 or C led to associa...

journal_title：Bulletin of experimental biology and medicine

authors： Aksenov DV,Mel'nichenko AA,Suprun IV,Yanushevskaya EV,Vlasik TN,Sobenin IA,Panasenko OM,Orekhov AN

更新日期：2005-10-01 00:00:00

abstract：:Morphological signs of early interstitial fibrosis, developing under conditions of acute viral inflammation (postinfection days 1-14), were observed in C57Bl/6 mice infected with influenza A/H5N1 A/goose/Krasnoozerskoye/627/05 virus. The development of fibrosis was confirmed by an increase in the number of lung cells ...

journal_title：Bulletin of experimental biology and medicine

authors： Anikina AG,Shkurupii VA,Potapova OV,Kovner AV,Shestopalov AM

更新日期：2014-04-01 00:00:00

abstract：:The distribution of polymorphic variants of innate immunity genes TLR9 (+2848G>A) and DEFB1(-20G>A; -44C>G; -52G>A) was evaluated in long-living individuals. No significant differences were found in the distribution of genotypes and alleles of the TLR9 gene. The following features were revealed: increase in the freque...

journal_title：Bulletin of experimental biology and medicine

authors： Gankovskaya LV,Svitich OA,Artem'eva OV,Miroshnichenkova AM,Rusanova KV

更新日期：2015-05-01 00:00:00

abstract：:Activation of free radical oxidation and inhibition of antioxidant activity in mouse myocardium after long-term dipyridamole treatment were demonstrated using chemiluminescent techniques. At the same time, dipyridamole 10-fold inhibited free radical oxidation and slightly increased antioxidant activity in the plasma. ...

journal_title：Bulletin of experimental biology and medicine

authors： Ivasenko IN,Shlyakhto EV

更新日期：2001-06-01 00:00:00

abstract：:We studied the effect of Selank administered intraperitoneally in doses of 100, 300, and 1000 μg/kg to male Wistar rats 15 min prior to restraint stress on the content of aminotransferases and total protein concentration in blood serum and intensity of free radical oxidation in the liver. Under conditions of acute res...

journal_title：Bulletin of experimental biology and medicine

authors： Fomenko EV,Bobyntsev II,Kryukov AA,Ivanov AV,Andreeva LA,Myasoedov NF

更新日期：2017-08-01 00:00:00

abstract：:Signal pathways of realization of growth potential of mesenchymal progenitor cells related to transcription factor NF-κB were studied in vitro. NF-κB was found to participate in the proliferation and differentiation of progenitor elements that can be blocked by its specific inhibitor oridonin. NF-κB inhibitor aurothio...

journal_title：Bulletin of experimental biology and medicine

authors： Zyuz'kov GN,Danilets MG,Ligacheva AA,Zhdanov VV,Udut EV,Miroshnichenko LA,Simanina EV,Trofimova ES,Minakova MY,Chaikovskii AV,Agafonov VI,Dygai AM

更新日期：2013-10-01 00:00:00

abstract：:We estimated the percentage of CD4+ lymphocytes synthesizing IFN-gamma and IL-4 in the peripheral blood and measured the concentrations of IL-1, IL-6, and TNF-alpha in lochia of patients with postpartum endometritis. T lymphocytes with intracellular IFN-gamma prevailed in women with physiological course of the postpar...

journal_title：Bulletin of experimental biology and medicine

authors： Sukhikh GT,Kasabulatov NM,Van'ko LV,Ordzhonikidze NV,Veryasov VN,Danelyan SZh

更新日期：2005-12-01 00:00:00

abstract：:The combined cytostatic effect of doxorubicin and gestagens progesterone, medroxyprogesterone acetate, mecigestone, and butagest on doxorubicin-resistant and doxorubicin-sensitive human breast cancer MCF-7 cells was studied by the MTT assay. On the 6th day of incubation progesterone, medroxyprogesterone acetate, mecig...

journal_title：Bulletin of experimental biology and medicine

authors： Sergeev PV,Semeikin AV,Fedotcheva TA,Samoilikov RV,Kamernitskii AV,Levina IS,Rzheznikov VM,Grinenko GS,Korystov YN,Ermakova NV,Shaposhnikova VV,Shimanovskii NL

更新日期：2003-11-01 00:00:00

abstract：:In experiments on narcotized rats, BP in the left femoral artery as well as local electrical potential and electrical impedance of the symmetric segment of the right femoral artery were simultaneously recorded in situ with two extracellular nonpolarizable Ag/AgCl electrodes located along the artery at a distance of 3 ...

journal_title：Bulletin of experimental biology and medicine

authors： Revenko SV,Tikhomirova LN,Nesterov AV,Tarakanov IA

更新日期：2018-04-01 00:00:00

abstract：:The role of JNK-mediated signal pathway and participation of p53 transcription factor in stimulation of mesenchymal precursor cell function by the fibroblast growth factor was studied. The levels of fibroblast colony- and cluster formation and proliferative activity of mesenchymal precursors increased in response to J...

journal_title：Bulletin of experimental biology and medicine

authors： Zyuz'kov GN,Zhdanov VV,Udut EV,Miroshnichenko LA,Khrichkova TY,Danilets MG,Simanina EV,Chaikovskii AV,Agafonov VI,Sherstoboev EY,Minakova MY,Burmina YV,Udut VV,Dygai AM

更新日期：2015-08-01 00:00:00

abstract：:We studied the effect of 10-week treatment with intranasal insulin (0.5 IU/day) on glucose tolerance, glucose utilization, lipid metabolism, functions of pancreatic β cells, and insulin system in the liver of rats with cafeteria diet-induced metabolic syndrome. The therapy reduced body weight and blood levels of insul...

journal_title：Bulletin of experimental biology and medicine

authors： Derkach KV,Ivantsov AO,Chistyakova OV,Sukhov IB,Buzanakov DM,Kulikova AA,Shpakov AO

更新日期：2017-06-01 00:00:00

abstract：:An open comparative clinical study evaluated the efficiency of Proproten-100 in reliving affective, somatovegetative, behavioral, and cognitive post-withdrawal disorders and manifestations of primary pathological alcohol addiction in patients with alcohol dependence in the stage of therapeutic remission. We compared t...

journal_title：Bulletin of experimental biology and medicine

authors： Bokhan NA,Abolonin AF,Krylov EN,Vetlugina TP,Ivanova SA,Epstein OI

更新日期：2003-01-01 00:00:00

abstract：:An important role in the development of the immune response is played by macrophages that acquire either anti-inflammatory M1 or anti-inflammatory M2 phenotype depending on their microenvironment. The possibility of targeted reprogramming of the initial M2 macrophage phenotype towards M1 phenotype and vice versa using...

journal_title：Bulletin of experimental biology and medicine

authors： Lyamina SV,Kruglov SV,Vedenikin TY,Borodovitsyna OA,Suvorova IA,Shimshelashvili ShL,Malyshev IY

更新日期：2012-02-01 00:00:00

abstract：:A test system developed by the authors was used to measure serum concentrations of soluble Fas in patients with malignant and benign tumors of different location and morphology. Relationships between soluble Fas levels and the main clinical and morphological characteristics of cancer were evaluated. It is proven that ...

journal_title：Bulletin of experimental biology and medicine

authors： Abbasova SG,Vysotskii MM,Ovchinnikova LK,Obusheva MN,Digaeva MA,Britvin TA,Bahoeva KA,Karabekova ZK,Kazantzeva IA,Mamedov UR,Manuchin IB,Davidov MI

更新日期：2009-10-01 00:00:00

abstract：:The time course of angiotensin-converting enzyme activity in the rat aorta after fractionated exposure to ionizing radiation and the effects of dihydroquercetin and fucoidin on this parameter were studied. Male Wistar rats were exposed to single or repeated (fractionated) X-ray radiation in a dose of 2.5 Gy at 200 kV....

journal_title：Bulletin of experimental biology and medicine

authors： Korystova AF,Kublik LN,Kim YA,Levitman MK,Shaposhnikova VV,Korystov YN

更新日期：2018-07-01 00:00:00

abstract：:Intravenous infection of chicken with H5N1 avian influenza virus (strain A/Gs/Krasnoozerskoye/627/05) causes rapid lethal outcome. Pathomorphological study of bird viscera showed manifestations of disseminated intravascular coagulation syndrome, generalized inflammatory reaction, and wide-scale necrobiotic changes in ...

journal_title：Bulletin of experimental biology and medicine

authors： Shestopalova LV,Shkurupiy VA,Sharkova TV,Shestopalov AM

更新日期：2008-12-01 00:00:00