Abstract:
:Induction of direct cell death is one of the mechanisms of the antitumor effect of GD2-specific antibodies used for the therapy of high-risk neuroblastoma. The mechanisms of the cytotoxic signal triggered by antibody binding to GD2 ganglioside on the surface of the tumor cell remain insufficiently studied. Using inhibitor analysis we demonstrated that actin microfilaments are involved in the cell death induced by GD2-specific antibodies. Specifically, a strong antagonistic influence of cytochalasin D on the cytotoxic effect induced by GD2-specific antibodies was demonstrated in GD2+ tumor cell lines, which was expressed in at least 20% increase in cell survival and a significant decrease of the fraction of cells with fragmented DNA.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Doronin II,Kholodenko IV,Zubareva AA,Yarygin KN,Deev SM,Kholodenko RVdoi
10.1007/s10517-019-04389-0subject
Has Abstractpub_date
2019-02-01 00:00:00pages
541-547issue
4eissn
0007-4888issn
1573-8221pii
10.1007/s10517-019-04389-0journal_volume
166pub_type
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