Involvement of Actin Filaments in the Cytotoxic Effect of GD2-Specific Antibodies.

Abstract:

:Induction of direct cell death is one of the mechanisms of the antitumor effect of GD2-specific antibodies used for the therapy of high-risk neuroblastoma. The mechanisms of the cytotoxic signal triggered by antibody binding to GD2 ganglioside on the surface of the tumor cell remain insufficiently studied. Using inhibitor analysis we demonstrated that actin microfilaments are involved in the cell death induced by GD2-specific antibodies. Specifically, a strong antagonistic influence of cytochalasin D on the cytotoxic effect induced by GD2-specific antibodies was demonstrated in GD2+ tumor cell lines, which was expressed in at least 20% increase in cell survival and a significant decrease of the fraction of cells with fragmented DNA.

journal_name

Bull Exp Biol Med

authors

Doronin II,Kholodenko IV,Zubareva AA,Yarygin KN,Deev SM,Kholodenko RV

doi

10.1007/s10517-019-04389-0

subject

Has Abstract

pub_date

2019-02-01 00:00:00

pages

541-547

issue

4

eissn

0007-4888

issn

1573-8221

pii

10.1007/s10517-019-04389-0

journal_volume

166

pub_type

杂志文章
  • Involvement of the Coronary Bed in Patients with Coronary Heart Disease against the Background of Primarily Coronary and Generalized Atherosclerosis.

    abstract::Significant associations between clinical history factors, lipid metabolism parameters, and type of atherosclerotic process (area of vascular lesions and severity of clinical manifestations) were detected. The predominance of generalized atherosclerosis in chronic coronary heart disease group was associated with patie...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-016-3595-8

    authors: Bakarev MA,Karpova AA,Pichigin VI,Nikityuk DB,Lushnikova EL

    更新日期:2016-12-01 00:00:00

  • The Content of Multipotent Stromal Cells in 3-4.5-Month Heterotopic Bone Marrow Transplants of CBA Mice Subjected to a Single Exposure to Osteogenic Stimuli (Curettage, BMP-2) or Antigens (S. typhimurium antigenic complex, LPS).

    abstract::At the early stages of development (3 months), transplants from bone marrow donors subjected to single in vivo stimulation (curettage, administration of BMP-2 or antigenic complex of S. typhimurium) 1 day before transplantation were characterized by significantly elevated content of nucleated cells (by 1.4, 1.9 and 2....

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-017-3754-6

    authors: Gorskaya YF,Nesterenko VG

    更新日期:2017-05-01 00:00:00

  • Morphofunctional State of the Periodontal Tissues in Humans and Rats with Arterial Hypertension.

    abstract::We performed comparative analysis of hemodynamic in the periodontal microcirculatory bed in adolescents with arterial hypertension (AH) and morphological changes in the periodontal tissues of in hypertensive ISIAH rats of comparable biological age. In the periodontal tissues of adolescents with hypertension, the blood...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-020-04990-8

    authors: Kolesnikova LR,Darenskaya MA,Kolesnikova LI,Grebenkina LA,Korytov LI,Batoroev YK,Belinskaya EI,Mikhalevich IM,Kolesnikov SI

    更新日期:2020-10-01 00:00:00

  • Optimal detection of serum antipaternal antileukocytic antibodies after injection of allogenic lymphocytes in women with habitual abortions.

    abstract::The level of antipaternal antileukocytic antibodies detected by flow cytometry is a parameter reflecting the efficiency of alloimmunization of women with reproductive disorders during preparation to pregnancy. The results of evaluation of antipaternal antileukocytic antibodies by two modifications of the method are pr...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-012-1811-8

    authors: Krechetova LV,Nikolaeva MA,Van'ko LV,Ziganshina MM,Golubeva EL,Stepanova EO,Sukhikh GT

    更新日期:2012-09-01 00:00:00

  • Effects of Chronic Tobacco Smoking on the Distribution of Tachykinin Receptors in Rat Pial Arteries.

    abstract::Pial arteries of different diameter were studied in intact rats and after 6-month modeling of chronic tobacco smoking in rats. Expression of tachykinin NK1 receptors in pial arteries was studied by biomicroscopy and immunohistochemical methods. Chronic tobacco smoking induced considerable reorganizations of the arteri...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-017-3792-0

    authors: Zakharchuk NV,Chertok VM,Nevzorova VA,Gonchar EY

    更新日期:2017-07-01 00:00:00

  • Nociceptive thresholds and indexes of hyperthermia in rats treated with lipopolysaccharide pyrogenal.

    abstract::The relationships between open field behavior, initial nociceptive thresholds, and immunoreactivity assessed according to the development of hyperthermia triggered by LPS pyrogenal were examined in Wistar rats. Behaviorally active animals demonstrated higher nociceptive thresholds and greater immunoreactivity in compa...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-011-1478-6

    authors: Abramova AY,Abramov YB

    更新日期:2011-12-01 00:00:00

  • Correlation of intracellular Ca(2+)-activated proteinase activity and cholesterol content in white sea mussel (Mytilus edulis) membranes at different water saltiness.

    abstract::Correlation between changes in activity of intracellular Ca(2+)-activated proteinases and cholesterol content in mussels in response to changes in habitat saltiness was detected in mollusks from littoral and sublittoral White sea zones. Calpain activity in mussels decreased in low water saltiness and increased in high...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-005-0518-5

    authors: Kyaivyaryainen EI,Nefedova ZA,Bondareva LA,Alekseeva NN,Nemova NN

    更新日期:2005-10-01 00:00:00

  • Ultrastructure of nuclear compartment in cardiomyocytes during regenerative and plastic insufficiency of the myocardium.

    abstract::We studied ultrastructure of nuclear compartment in cardiomyocytes during regenerative and plastic insufficiency of the myocardium induced by anthracycline antibiotic daunomycin. A peculiarity of ultrastructural organization of cardiomyocyte nuclei under these conditions is almost complete disappearance of the heteroc...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:

    authors: Nepomnyashchikh LM,Lushnikova EL,Semenov DE

    更新日期:2000-12-01 00:00:00

  • Content of steroid hormones in the blood and adrenal glands of mice in the dynamics of BCG- and SiO2-induced granulomatous inflammation.

    abstract::Individual or combined administration of BCG vaccine and silicon dioxide to male mice induced a nonspecific stress response of the adrenal glands and gonads judging from changes in the concentration of blood cortisol and testosterone. The dynamics of cortisol concentration in the adrenal glands was similar, while chan...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-009-0396-3

    authors: Palchikova NA,Kuzminova OI,Utkina NV,Selyatitskaya VG,Shkurupiy VA

    更新日期:2008-12-01 00:00:00

  • Peculiarities of in vitro immune response to mycobacterial antigens in inbred I/St mice.

    abstract::Comparative study on inbred mouse stains showed that in vitro response of T lymphocytes from tuberculosis-susceptible I/St mice to mycobacterial antigens did not differ from that of T lymphocytes from resistant mouse strains. The defect appeared only in the presence of virulent mycobacteria and was not related to T ly...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/BF02434877

    authors: Radaeva TV,Nikonenko BV

    更新日期:2000-06-01 00:00:00

  • Changes in thyroid status of rats after prolonged exposure to low dose dichlorodiphenyltrichloroethane.

    abstract::The effect of low dose dichlorodiphenyltrichloroethane (DDT), omnipresent ecotoxicant and endocrine disruptor, on the functioning of the endocrine system is an urgent problem. We studied the effect of low dose DDT on thyroid status in rats. Rats receiving DDT in a dose of 1.890±0.086 μg/kg for 6 weeks showed increased...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-014-2443-y

    authors: Yaglova NV,Yaglov VV

    更新日期:2014-04-01 00:00:00

  • Ultrastructural study of cell populations in the gastric transplant after esophagoplasty.

    abstract::Ultrastructural characteristics of cell populations in the gastric tube mucosa were studied after plastic surgery for benign esophageal disease. The foveolar epithelium mainly consisted of secretory active mucocytes with small changes in cytoplasmic organelles. Functionally immature parietal cells and gland cells in t...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-011-1175-5

    authors: Lapii GA,Nepomnyashchikh LM,Sudovykh IE,Kutepov AV,Govorkov RV

    更新日期:2011-02-01 00:00:00

  • Antidepressant, psychostimulant, and nootropic effects of major and trace element composition.

    abstract::The antidepressant, psychostimulant, and nootropic effects of a composition of major and trace elements including KCl, RbNO3, magnesium sulfate, and zinc sulfate were studied on the models of behavioural despair (Porsolt test) and conditioned passive avoidance test. The preparation was found to shorten the immobilizat...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-013-2113-5

    authors: Afanasieva OG,Suslov NI,Shilova IV

    更新日期:2013-06-01 00:00:00

  • Transplantation of bone marrow mononuclear cells does not affect postinfarction electrical remodeling of the heart.

    abstract::We studied the effect of allotransplantation of bone marrow mononuclear cells on postinfarction remodeling of the heart in rats. The cells were transplanted into the periinfarction zone of the heart. The transplantation was performed on day 9 after coronary occlusion. It was found that on day 45 after coronary occlusi...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-008-0029-2

    authors: Maslov LN,Shakhov VP,Krylatov AV,Platonov AA

    更新日期:2008-01-01 00:00:00

  • Participation of IIb-IIIa glycoprotein in spontaneous platelet aggregation.

    abstract::In some patients with stable and unstable angina pectoris and in some donors without clinical manifestations of cardiovascular diseases and other pathologies, spontaneous platelet aggregation was completely suppressed by glycoprotein IIb-IIIa antagonists blocking the interaction of this glycoprotein with fibrinogen. A...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-007-0146-3

    authors: Sirotkina OV,Zabotina AM,Taraskina AE,Sivachenko EB,Zueva EE,Kadinskaya MI,Buryachkovskaya LI,Uchitel' IA,Khaspekova SG,Vavilova TV,Shvartsman AL,Mazurov AV

    更新日期:2007-04-01 00:00:00

  • Morphological changes in immune and endocrine organs of mice injected with a gonadotropin-releasing hormone analog.

    abstract::Infection of surfagon (gonadotropin-releasing hormone analog) in a dose of 0.1 microg/kg to male CBA mice stimulated lymphocyte migration from splenic B zones, caused moderate thinning of the thymic cortex, thickening of the zona fasciculata of the adrenal cortex with signs of corticocyte activation. After administrat...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-005-0225-2

    authors: Bobyntsev II,Dolzhikov AA,Severyanova LA

    更新日期:2005-01-01 00:00:00

  • Effect of glycine on the microcirculation in rat mesenteric vessels.

    abstract::Model experiments on biomicroscopy of mesenteric microvessels in laboratory rats were performed to evaluate the effect of natural metabolites (e.g., amino acid glycine) on the microcirculation. The effect of glycine was determined from a change in the diameter of arterioles. Application of glycine (0.1 ml, 1 M) to the...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-009-0498-y

    authors: Podoprigora GI,Nartsissov YR

    更新日期:2009-03-01 00:00:00

  • Effects of titanium dioxide nanoparticles on small intestinal mucosa in rats.

    abstract::Penetration of titanium dioxide nanoparticles into enterocytes after their administration into isolated loop of rat small intestine was shown in vivo by transmission electron microscopy. Using electron diffraction, titanium dioxide nanoparticles were identified in the apical regions of the cells under plasma membranes...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-012-1928-9

    authors: Onishchenko GE,Erokhina MV,Abramchuk SS,Shaitan KV,Raspopov RV,Smirnova VV,Vasilevskaya LS,Gmoshinski IV,Kirpichnikov MP,Tutelyan VA

    更新日期:2012-12-01 00:00:00

  • Assessment of Biocompatibility and Local Action of Biomaterial for Production of an Envelope for Implanted Heart Electronic Devices.

    abstract::We studied a biomaterial for a new domestic product, a biological envelope for implantation of cardiac electronic devices. The product is designed to prevent complications after pacemaker implantation and to facilitate the reimplantation procedure. By chemical and biological processing of raw materials (submucosa of p...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-020-04712-0

    authors: Shadrina DV,Venediktov AA,Evdokimov SV,Vaskovskii VA,Artyukhina EA,Revishvili AS,Durmanov SS,Bazylev VV

    更新日期:2020-01-01 00:00:00

  • Molecular mechanisms of hormone resistance of breast cancer.

    abstract::More than 70% malignant mammary tumors contain steroid hormone receptors; this suggests the possibility of hormone therapy in the majority of patients with breast cancer (BC). The main cause of inefficiency of hormone therapy in BC is hormone resistance (tumor resistance to hormonal cytostatics). Here we discuss the m...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-013-2160-y

    authors: Scherbakov AM,Krasil'nikov MA,Kushlinskii NE

    更新日期:2013-07-01 00:00:00

  • Effect of succinic acid and tween-80 on glucuronidation of 2-ethyl-6-methyl-3-hydroxypyridine.

    abstract::We studied the effect of succinic acid on the process of glucuronidation of 2-ethyl-6-methyl-3-hydroxypyridine after peroral and intraperitoneal administration in the form of succinate or a base. Since the basic form of 2-ethyl-6-methyl-3-hydroxypyridine is insoluble in water, it was administered in 5% Tween-80. It wa...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-008-0205-4

    authors: Baranov PA,Kravtsova OU,Sariev AK,Sherdev VP

    更新日期:2008-07-01 00:00:00

  • Cardioprotective Effect of Modified Peroxiredoxins in Retrograde Perfusion of Isolated Rat Heart under Conditions of Oxidative Stress.

    abstract::Antioxidant properties of recombinant peroxiredoxin-6 and chimeric protein PSH combining peroxidase and superoxide dismutase activities were studied on the model of retrograde perfusion of isolated rat heart under conditions of H2O2-induced oxidative stress. The exogenous antioxidant proteins exhibited cardioprotectiv...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-016-3237-1

    authors: Karaduleva EV,Mubarakshina EK,Sharapov MG,Volkova AE,Pimenov OY,Ravin VK,Kokoz YM,Novoselov VI

    更新日期:2016-03-01 00:00:00

  • Protective characteristics of platelets in tuberculosis.

    abstract::We demonstrated specific changes in platelet structure in different types of tuberculous process, in particular, shift in the proportion between alpha-granules, dense granules, different disorders in the mitochondrial and lysosomal apparatus, etc. The role of platelets in immune process is studied. Redistribution of a...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-005-0084-x

    authors: Khechinashvili GN,Khvitiya NG

    更新日期:2004-11-01 00:00:00

  • Analysis of associations of NAT2 gene polymorphisms with the risk of lung cancer.

    abstract::The incidence of 5 polymorphisms of N-acetyltransferase-2 gene was evaluated in patients with lung cancer. A803G polymorphism is a factor of lung cancer resistance in tobacco smoking Caucasians in Novosibirsk. Opposite effects of NAT2 gene polymorphisms on the risk of lung cancer are possible. ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-007-0023-0

    authors: Nikishina MV,Vavilin VA,Makarova SI,Lyakhovich VV

    更新日期:2007-01-01 00:00:00

  • Experimental gastric ulcer: gastro- and duodenoprotective effects of sibusol.

    abstract::We studied the influence of pretreatment with chemical mildronate analogue sibusol on the course of experimental gastric ulcer in rats. Sibusol produced a protective effects on the stomach and duodenum. ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/b:bebm.0000024380.24282.0b

    authors: Lychkova AE,Savchuk VI,Smirnov VM

    更新日期:2004-01-01 00:00:00

  • Prooxidant-antioxidant state of the organism during oxidative stress and correction of the L-arginine-NO system.

    abstract::The prooxidant-antioxidant balance in rats with oxidative stress was studied during correction of the L-arginine-NO system. Oxidative stress was induced by intravenous injection of E. coli lipopolysaccharide. Under conditions of oxidative stress the prooxidant-antioxidant imbalance was least pronounced during selectiv...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-006-0178-0

    authors: Glebov AN,Zinchuk VV

    更新日期:2006-04-01 00:00:00

  • Effect of Proline-Containing Oligopeptides PGP and RGP on Proliferative and Protein-Synthesizing Activity of Cultured Pulmonary Fibroblasts under Conditions of Oxidative Stress.

    abstract::We studied the effect of glyprolines Pro-Gly-Pro (PGP) and Arg-Gly-Pro (RGP) on the primary culture of pulmonary fibroblasts from newborn albino rats under normal conditions and during oxidative stress. Under physiological conditions, the peptides had no effect on parameters of cell division. Hydrogen peroxide induced...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-016-3372-8

    authors: Tolstenok IV,Fleishman MY,Sazonova EN,Lebed'ko OA,Maltseva IM,Myasoedov NF,Timoshin SS

    更新日期:2016-05-01 00:00:00

  • Optimal choice of vacuum-membrane skeletal muscle extension.

    abstract::Peculiarities of skin extension under vacuum applicators (nozzles) of various design was studied in 20 volunteers aged 18-25 years. The data obtained made it possible to chose optimal parameters of elastic membranes of the vacuum cups that produce stretch sufficient for vacuum-membrane skeletal muscle extension with m...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/a:1015550922784

    authors: Alekseev YN,Smirnov BM,Alekseev NY

    更新日期:2002-02-01 00:00:00

  • Influence of Implants Surface Properties on Bone Tissue Formation in the Ectopic Osteogenesis Test.

    abstract::We studied the influence of the characteristics of oxide porous coatings on osteogenesis and integration of new bone tissue and titanium implant surface in the ectopic osteogenesis test. Implants with coating with pore size 2-20 μ exhibit better osteogenic and osteoconductive characteristics than implants with homogen...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-017-3719-9

    authors: Nadezhdin SV,Zubareva EV,Burda YE,Kolobov YR,Ivanov MB,Khramov GV,Afanas'ev AY

    更新日期:2017-04-01 00:00:00

  • Involvement of Wulst neurons in hiding reaction of pied flycatcher nestlings with different visual afferentation.

    abstract::We studied transcriptional activity in the higher avian center visual system (Wulst area) in acoustically guided defensive behavior in visually deprived and non-deprived nestlings to evaluate the effects of visual afferentation on functional involvement of visual structures in acoustically guided defensive behavior. E...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-012-1781-x

    authors: Korneeva EV,Tiunova AA,Alexandrov LI

    更新日期:2012-09-01 00:00:00