Abstract：
:Serum concentration of copper, immunoreactive polypeptides of ceruloplasmin and its oxidase activity, and the number of copper atoms per ceruloplasmin molecule were decreased in patients with Parkinson's disease in comparison with the corresponding parameters in age-matched healthy individuals, but the ratio of apoceruloplasmin to holoceruloplasmin in patients with Parkinson's disease was similar in both groups. Treatment of blood serum with Helex 100, a high-affinity copper chelator, revealed reduced content of labile copper atoms per ceruloplasmin molecule in patients with Parkinson's disease in comparison with that in healthy controls. The mechanism underlying impaired metabolic incorporation of labile copper atoms into CP molecule is discussed as a possible cause of copper dyshomeostasis associated with Parkinson's disease.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Karpenko MN,Ilyicheva EY,Muruzheva ZM,Milyukhina IV,Orlov YA,Puchkova LVdoi
10.1007/s10517-018-4039-4subject
Has Abstractpub_date
2018-03-01 00:00:00pages
596-600issue
5eissn
0007-4888issn
1573-8221pii
10.1007/s10517-018-4039-4journal_volume
164pub_type
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