Abstract：
:We studied the effects of optical (dd-, ll-, dl-, and ld-dipeptides with alpha-bond, EW) structural isomers and cyclic (dd-, ll-, dl-, and ld-dipeptides with gamma-bond, iEW) analogs of Glu-Trp synthetic dipeptide on the population of normal hemopoietic stem cells. Dipeptides containing lGlu (lGlu-lTrp, lGlu-dTrp) injected to mice were inert towards committed bone marrow CFU-S; dGlu-containing dipeptides (dGlu-dTrp, dGlu-lTrp) inhibited the growth of CFU-S-8; and LiGlu-dTrp stimulated these cells. Inhibitory or stimulatory effects of optical and chemical isomers of Glu-Trp dipeptide are determined by optical orientation and nature of peptide bond of Glu residue. The effects of cyclic and mixed peptides towards colony formation are similar to those of the corresponding linear dipeptides.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Semina OV,Semenets TN,Zamulaeva IA,Selivanova EI,Malyutina YV,Saenko AS,Deigin VIdoi
10.1007/s10517-006-0141-0subject
Has Abstractpub_date
2006-02-01 00:00:00pages
250-3issue
2eissn
0007-4888issn
1573-8221journal_volume
141pub_type
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