Abstract：
:We studied the effect of glyprolines Pro-Gly-Pro (PGP) and Arg-Gly-Pro (RGP) on the primary culture of pulmonary fibroblasts from newborn albino rats under normal conditions and during oxidative stress. Under physiological conditions, the peptides had no effect on parameters of cell division. Hydrogen peroxide induced intensive oxidative stress accompanied by suppression of protein-synthesizing function. When hydrogen peroxide was added to the culture containing the test peptides, correction of the oxidative status was observed accompanied by activation of DNA-synthesizing activity and inhibition of lucigenin-dependent chemiluminescence.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Tolstenok IV,Fleishman MY,Sazonova EN,Lebed'ko OA,Maltseva IM,Myasoedov NF,Timoshin SSdoi
10.1007/s10517-016-3372-8subject
Has Abstractpub_date
2016-05-01 00:00:00pages
184-6issue
1eissn
0007-4888issn
1573-8221pii
10.1007/s10517-016-3372-8journal_volume
161pub_type
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