Abstract：
:The gene expression profiles of MDA-MB-231 cell line of breast cancer and xenografts derived from this tumor in murine model were analyzed using GeneChip Human Transcriptome array 2.0 platform (Affymetrix). A more than 1000-fold increase in the MIR1973 gene expression was observed in the xenografts compared to the original cell line. Real-time reverse transcription PCR showed that the content of mature hsa-miR-1973 microRNA encoded by this gene was elevated in the xenografts by more than 300 times. According to microarray analysis, none of hsa-miR-1973 target genes available in the databases changed the expression in the cell line and xenografts. A possible role of hsa-miR-1973 is reduction of apoptosis in the tumor.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Fomicheva KA,Knyazev EN,Mal'tseva DVdoi
10.1007/s10517-017-3873-0subject
Has Abstractpub_date
2017-09-01 00:00:00pages
660-662issue
5eissn
0007-4888issn
1573-8221pii
10.1007/s10517-017-3873-0journal_volume
163pub_type
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journal_title：Bulletin of experimental biology and medicine
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abstract：:We studied the specific features of ultrasonic vocalization of Wistar rats in various motivational and emotional states. No significant changes were found in ultrasonic vocalization of rats during experimental food motivation and after the satisfaction of food requirements. The state of thirst and satisfaction of wate...
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