Evaluation of hepatoprotective activity of water-soluble polysaccharide fraction of Stellaria media L.

abstract：:Treatment with a combination of artrofoon and anaferon significantly reduced clinical and laboratory parameters of rheumatoid inflammation and significantly decreased the content of antiinflammatory cytokines in the blood. These findings attest to antiinflammatory and immunomodulating effects of these preparations. ...

journal_title：Bulletin of experimental biology and medicine

authors： Petrov VI,Babaeva AR,Solodenkova KS,Cherevkova EV,Zabolotneva YA,Kachanova MV,Sergeeva SA

更新日期：2009-09-01 00:00:00

abstract：:The effect of intravenous transplantation of mesenchymal stem cells on the recovery of cognitive functions was studied in Wistar-Kyoto rats after brain stroke induced by occlusion of the middle cerebral artery in the left hemisphere. Analysis 2 and 5 weeks after stroke showed that transplantation of mesenchymal stem c...

journal_title：Bulletin of experimental biology and medicine

authors： Sokolova IB,Fedotova OR,Zin'kova NN,Kruglyakov PV,Polyntsev DG

更新日期：2006-10-01 00:00:00

abstract：:Differential expression of type 1 cannabinoid receptors (CR1) was evaluated at different stages of human skin fibroblast transformation into terminally differentiated neurons. Immunocytochemical staining detected no CR1 on fibroblasts, but their transformation into induced pluripotent stem cells was accompanied by mar...

journal_title：Bulletin of experimental biology and medicine

authors： Bobrov MY,Bezuglov VV,Khaspekov LG,Illarioshkin SN,Novosadova EV,Grivennikov IA

更新日期：2017-06-01 00:00:00

abstract：:The incidence of 5 polymorphisms of N-acetyltransferase-2 gene was evaluated in patients with lung cancer. A803G polymorphism is a factor of lung cancer resistance in tobacco smoking Caucasians in Novosibirsk. Opposite effects of NAT2 gene polymorphisms on the risk of lung cancer are possible. ...

journal_title：Bulletin of experimental biology and medicine

authors： Nikishina MV,Vavilin VA,Makarova SI,Lyakhovich VV

更新日期：2007-01-01 00:00:00

abstract：:Here we addressed a question of whether gamma oscillations previously described in the whisker-related barrel cortex are a universal pattern of activity in the somatosensory cortex of newborn rats. Intracortical recording of local field potentials and action potentials in neurons using multisite silicon electrodes in ...

journal_title：Bulletin of experimental biology and medicine

authors： Gerasimova EV,Zakharov AV,Lebedeva YA,Inacio AR,Minlebaev MG,Sitdikova GF,Khazipov RN

更新日期：2014-01-01 00:00:00

abstract：:Structural changes in the brain of outbred mice were studied after infection with influenza A/H5N1 strain isolated in the Novosibirsk region. High mortality was observed after intranasal infection. Examination of brain specimens revealed vasculopathies with thrombosis of the microcirculatory vessels, pericellular and ...

journal_title：Bulletin of experimental biology and medicine

authors： Potapova OV,Shkurupy VA,Sharkova TV,Shestopalov AM

更新日期：2009-12-01 00:00:00

abstract：:We demonstrated the influence of short peptides on the expression of signaling molecules in organotypic culture of the pineal gland from 3-month-old rats. Peptides Ala-Glu-Asp-Gly and Lys-Glu-Asp stimulate the expression of proliferative protein Ki-67 in pineal gland culture. These peptides as well as Glu-Asp-Arg and ...

journal_title：Bulletin of experimental biology and medicine

authors： Khavinson VKh,Linkova NS,Chalisova NI,Dudkov AV,Koncevaya EA

更新日期：2011-11-01 00:00:00

abstract：:cDNA encoding VEGF and Ig-like extracellular domains 2-4 of VEGFR-1 (sFlt-1(2-4)) were cloned into prokaryotic expression vectors pET32a and pQE60. Recombinant proteins were purified (metal affinity chromatography) and renatured. Chemiluminescent study for the interaction of recombinant VEGF and sFlt-1(2-4) showed tha...

journal_title：Bulletin of experimental biology and medicine

authors： Leopol'd AV,Baklaushev VP,Korchagina AA,Shein SA,Grinenko NF,Pavlov KA,Ryabukhin IA,Chekhonin VP

更新日期：2012-04-01 00:00:00

abstract：:Structural characteristics of the adrenal medulla in hypertensive NISAG rats (hereditary stress-induced arterial hypertension) were studied during various periods of postnatal ontogeny. Signs of hyperplasia of the adrenal medulla were most pronounced in adult hypertensive animals with persistent arterial hypertension,...

journal_title：Bulletin of experimental biology and medicine

authors： Buzueva II,Filyushina EE,Shmerling MD,Markel AL,Yakobson GS

更新日期：2006-12-01 00:00:00

abstract：:We studied changes in protein composition and their effects on convulsive activity in drug-induced and electrical kindling. Injection of protein fraction of brain extract from animals subjected to metronidazole-induced kindling to intact recipients reduced their sensitivity to the convulsant (i. e. increased the dose ...

journal_title：Bulletin of experimental biology and medicine

authors： Karpova MN,Karganov MY,Klishina NY,Khlebnikova NN,Kryzhanovskii GN

更新日期：2002-06-01 00:00:00

abstract：:Intraperitoneal injection of Semax (synthetic analogue of ACTH4-7, MEHFPGP) in a dose of 50 mg/kg produced a protective effect on rats with experimental indomethacin-induced ulcers. Experiments on narcotized rats showed that Semax in the studied dose had no effect on basal blood flow in the stomach, but prevented redu...

journal_title：Bulletin of experimental biology and medicine

authors： Zhuikova SE,Sergeev VI,Samonina GE,Myasoedov NF

更新日期：2002-06-01 00:00:00

abstract：:An important role in the development of the immune response is played by macrophages that acquire either anti-inflammatory M1 or anti-inflammatory M2 phenotype depending on their microenvironment. The possibility of targeted reprogramming of the initial M2 macrophage phenotype towards M1 phenotype and vice versa using...

journal_title：Bulletin of experimental biology and medicine

authors： Lyamina SV,Kruglov SV,Vedenikin TY,Borodovitsyna OA,Suvorova IA,Shimshelashvili ShL,Malyshev IY

更新日期：2012-02-01 00:00:00

abstract：:We proposed a mathematical model and estimated the parameters of adsorption of albumin-bilirubin complex to the surface of carbon pyropolymer. Design data corresponded to the results of experimental studies. Our findings indicate that modeling of this process should take into account fractal properties of the surface ...

journal_title：Bulletin of experimental biology and medicine

authors： Nikolaev AV,Rozhilo YA,Starozhilova TK,Sarnatskaya VV,Yushko LA,Mikhailovskii SV,Kholodov AS,Lobanov AI

更新日期：2005-09-01 00:00:00

abstract：:We studied plus-maze behavior of inbred Krushinskii-Molodkina, Wistar, and black-hooded rats (originating from the Long-Evans outbred strain) differing by predisposition to audiogenic seizures. The severity of audiogenic seizures partially correlated with anxiety and negatively correlated with the total level of locom...

journal_title：Bulletin of experimental biology and medicine

authors： Surina NM,Kalinina TS,Volkova AV,Malikova LA,Poletaeva II,Rayevsky KS,Fedotova IB

更新日期：2011-05-01 00:00:00

abstract：:The possibility of using hyaluronidase for the regulation of the state of different pools of mesenchymal precursors in vivo was demonstrated. The reaction of mesenchymal precursor cells depended on the dose of the enzyme. Administration of hyaluronidase in a dose of 20 U/mouse increased the content of stromal precurso...

journal_title：Bulletin of experimental biology and medicine

authors： Goldberg ED,Dygai AM,Zyuz'kov GN,Zhdanov VV,Simanina EV,Gur'yantseva LA

更新日期：2007-04-01 00:00:00

abstract：:Significant associations between clinical history factors, lipid metabolism parameters, and type of atherosclerotic process (area of vascular lesions and severity of clinical manifestations) were detected. The predominance of generalized atherosclerosis in chronic coronary heart disease group was associated with patie...

journal_title：Bulletin of experimental biology and medicine

authors： Bakarev MA,Karpova AA,Pichigin VI,Nikityuk DB,Lushnikova EL

更新日期：2016-12-01 00:00:00

abstract：:Activities of enzymes of active oxygen forms detoxication and phase II xenobiotic metabolism were measured in rat hepatoma 27 cells transplanted to different organs. Activity of phase II xenobiotic metabolizing enzymes was higher in hepatoma cells growing subcutaneously than in those transplanted into the liver, while...

journal_title：Bulletin of experimental biology and medicine

authors： Ostashkina NM,Dubovaya TK,Koblyakov VA,Konovalova GG,Lankin VZ

更新日期：2000-11-01 00:00:00

abstract：:Adhesion activity of L. acidophilus NK1, L. fermentum 90 TS4, and C. albicans 506 B on female vaginal epithelium was studied. Adhesion of various lactobacillus species was hormone-dependent. Adhesion of C. albicans 506 B was not associated with estrogen level. The effects of synthetic drugs and phytopreparations used ...

journal_title：Bulletin of experimental biology and medicine

authors： Rybas YA,Bustamante RA,Kravtsov EG,Tchernitchin AN,Dalin MV

更新日期：2012-07-01 00:00:00

abstract：:The mechanism of antiischemic effect of low-energy laser radiation was studied in rats with experimental myocardial infarction taking into consideration the effect of laser on hemoglobin affinity for oxygen and intensity of lipid peroxidation. Low-energy laser irradiation for 15 min in vitro decreased the area of myoc...

journal_title：Bulletin of experimental biology and medicine

authors： Gatsura SV,Gladkikh SP,Titov MN

更新日期：2004-04-01 00:00:00

abstract：:We revealed an antimetastatic effect of thymus-dependent corpuscular antigen (sheep erythrocytes) injected intravenously or intraperitoneally in sensitizing or high doses alone or in a complex with a course dose of cyclophosphamide to C57Bl/6 mice with Lewis carcinoma. Injection of the antigen appreciably reduced the ...

journal_title：Bulletin of experimental biology and medicine

authors： Mosienko MD,Mosienko VS,Solyanik GI,Kovalenko NG

更新日期：2004-06-01 00:00:00

abstract：:Antileprosy activity of dialkyldithiocarbamate derivatives was studied in experiments on mice infected with M. leprae into paw pads. We found that 2-diethyldithiocarbamoyl-3-cyano-5-nitropyridine is the most promising antileprosy agent; it effectively suppresses multiplication of M. leprae and is well tolerated under ...

journal_title：Bulletin of experimental biology and medicine

authors： Urlyapova NG,Yuschenko AA,Daudova AD,Makarov VA

更新日期：2008-04-01 00:00:00

abstract：:The linear parameters and number of Langerhans islets were evaluated in rats with alloxaninduced diabetes mellitus after transplantation of fetal pancreatic tissue to the anterior chamber of the eye. The islets significantly increased in size by week 3 after surgery and a trend to an increase in their number was obser...

journal_title：Bulletin of experimental biology and medicine

authors： Kulikov DA,Kulikov AV,Arkhipova LV,Smirnova GN,Dreval' AV,Tikhonova LP,Gaivoronskii IV,Sukhikh GT

更新日期：2015-01-01 00:00:00

abstract：:We measured the content of glutathione and activity of glutathione-metabolizing and antioxidant enzymes superoxide dismutase and catalase in samples obtained from 52 patients with malignant lung tumors and 20 patients with benign lung tumors. The content of glutathione and activity of glutathione-metabolizing enzymes ...

journal_title：Bulletin of experimental biology and medicine

authors： Korotkina RN,Matskevich GN,Devlikanova ASh,Vishnevskii AA,Kunitsyn AG,Karelin AA

更新日期：2002-06-01 00:00:00

abstract：:Biopsy specimens from patients with psoriasis treated with antiproliferative drugs (methotrexate, etretinate) were analyzed. Acanthosis and papillomatosis of the epidermis and inflammatory reaction of the derma decreased. A tendency to normalization of epidermocyte ultrastructure with regeneration of tonofilaments and...

journal_title：Bulletin of experimental biology and medicine

authors： Krinitsyna YM,Nepomnyashchikh GI,Aidagulova SV

更新日期：2001-08-01 00:00:00

abstract：:An open comparative clinical study evaluated the efficiency of Proproten-100 in reliving affective, somatovegetative, behavioral, and cognitive post-withdrawal disorders and manifestations of primary pathological alcohol addiction in patients with alcohol dependence in the stage of therapeutic remission. We compared t...

journal_title：Bulletin of experimental biology and medicine

authors： Bokhan NA,Abolonin AF,Krylov EN,Vetlugina TP,Ivanova SA,Epstein OI

更新日期：2003-01-01 00:00:00

abstract：:The incidence of mutations in the BRCA1 and BRCA2 genes in the studied sampling of 74 patients with ovarian cancer was 19%. The incidence of mutations in the Russian sampling of patients, formed without consideration for the family history, is one of the highest in European countries. Retrospective analysis showed tha...

journal_title：Bulletin of experimental biology and medicine

authors： Smirnova TY,Pospekhova NI,Lyubchenko LN,Tjulandin SA,Gar'kavtseva RF,Ginter EK,Karpukhin AV

更新日期：2007-07-01 00:00:00

abstract：:Initiation of apoptosis by chemotherapeutic drugs is one of the most effective approaches to the treatment of cancers. Caspases, the main enzymes of apoptosis, undergo activation to initiate cell death. Activation of initiator caspases requires their binding to special protein complexes. For elucidation of the mechani...

journal_title：Bulletin of experimental biology and medicine

authors： Zamaraev AV,Egorshina AY,Lavrik IN,Zhivotovsky BD,Kopeina GS

更新日期：2019-11-01 00:00:00

abstract：:In acute experiments on cats neural inotropic and lusitropic reactions of the heart to enhancement of pre- and afterload were assessed by changes in contractility and relaxation indices, which were preliminary chosen for their maximum specificity and sensitivity. The control cardiac responses to increased pre- and aft...

journal_title：Bulletin of experimental biology and medicine

authors： Alipov NN,Sokolov AV,Trubetskaya LV,Kuznetsova TE

更新日期：2003-04-01 00:00:00

abstract：:The combined cytostatic effect of doxorubicin and gestagens progesterone, medroxyprogesterone acetate, mecigestone, and butagest on doxorubicin-resistant and doxorubicin-sensitive human breast cancer MCF-7 cells was studied by the MTT assay. On the 6th day of incubation progesterone, medroxyprogesterone acetate, mecig...

journal_title：Bulletin of experimental biology and medicine

authors： Sergeev PV,Semeikin AV,Fedotcheva TA,Samoilikov RV,Kamernitskii AV,Levina IS,Rzheznikov VM,Grinenko GS,Korystov YN,Ermakova NV,Shaposhnikova VV,Shimanovskii NL

更新日期：2003-11-01 00:00:00

abstract：:The study examined effectiveness of pharmaco-cold cardioplegia employing solutions of enhanced buffer capacity during surgery of obstructive hypertrophic cardiomyopathy in adult patients (N=51) operated during 2013-2018. In group 1 (N=28), the cardioplegia was performed with HTK (Custodiol) solution, whereas in group ...

journal_title：Bulletin of experimental biology and medicine

authors： Bokeria LA,Egorov DN,Popov AE,Bledzhyants GA,Artyukhina TV,Movsesyan RR

更新日期：2020-07-01 00:00:00