Abstract:
:The incidence of mutations in the BRCA1 and BRCA2 genes in the studied sampling of 74 patients with ovarian cancer was 19%. The incidence of mutations in the Russian sampling of patients, formed without consideration for the family history, is one of the highest in European countries. Retrospective analysis showed that 9% patients carrying mutation had no family history of ovarian or breast cancer. The majority of mutations (86%) were detected in BRCA1 gene, where 5382insC mutation predominated (58%). These data suggest the possibility and advisability of screening for mutations in the BRCA1/2 genes in patients with ovarian cancer, particularly because this population includes patients without family history of ovarian and/or breast cancer.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Smirnova TY,Pospekhova NI,Lyubchenko LN,Tjulandin SA,Gar'kavtseva RF,Ginter EK,Karpukhin AVdoi
10.1007/s10517-007-0261-1subject
Has Abstractpub_date
2007-07-01 00:00:00pages
83-5issue
1eissn
0007-4888issn
1573-8221pii
doijournal_volume
144pub_type
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