Abstract:
:Human recombinant erythropoietin adsorbed on poly(butyl)cyanoacrylate nanoparticles and administered intraperitoneally in a dose of 0.05 mg/kg exhibited a neuroprotective effect in experimental intracerebral posttraumatic hematomas (hemorrhagic stroke) and reduced animal mortality. Human recombinant erythropoietin, native and adsorbed on lactic and glycolic acid copolymer-based nanoparticles, exhibited no antistroke effect on this model. Analysis of reverse transcription PCR products showed that human recombinant erythropoietin adsorbed on poly(butyl)cyanoacrylate nanoparticles more than 2-fold increased the expression of BDNF and NGF neurotrophins in the rat brain frontal cortex and hippocampus.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Solev IN,Balabanyan VY,Volchek IA,Elizarova OS,Litvinova SA,Garibova TL,Voronina TAdoi
10.1007/s10517-013-2123-3subject
Has Abstractpub_date
2013-06-01 00:00:00pages
242-4issue
2eissn
0007-4888issn
1573-8221journal_volume
155pub_type
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