Abstract：
:GABA, baclofen, isoguvacine increase, and cis-4-aminocrotonic acid does not modify resting membrane potential of muscle cells. Bicuculline, phaclofen, N-ethylmaleimide, chlorpromazine, verapamil, and removal of Ca2+ from bathing solution abolished the effect of baclofen, while U73122 and D609 were ineffective in this respect. The authors conclude that the Lumbricus terrestris muscle cells contain GABAergic structures similar to a- and b-receptors. Activation of GABA receptors induced Cl- inward current and Ca2+ entry with subsequent activation of calmodulin-like proteins, which causes membrane hyperpolarization by increasing the effect of "pumping potential" on resting membrane potential.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Volkov EM,Sabirova AR,Grishin SN,Zefirov ALdoi
10.1007/s10517-005-0261-ysubject
Has Abstractpub_date
2005-02-01 00:00:00pages
249-51issue
2eissn
0007-4888issn
1573-8221pii
doijournal_volume
139pub_type
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