Abstract：
:Olfactory ensheathing cells showed significant effects on the regeneration of the spinal cord in experimental models and in clinical trials. However, the use of these cells in the therapy of posttraumatic cysts of the spinal cord has not been studied. Cultures of human and rat olfactory mucosa were obtained according to the protocols developed by us. Passage 3-4 cultures are most enriched with olfactory ensheathing cells and are preferable for transplantation. We performed transplantation of 750,000 olfactory ensheathing cells into the region of modeled cysts. The therapeutic effect of human cells was more pronounced. The positive dynamics of recovery of motor activity in the hind limbs of rats can reflect regenerative processes in the spinal cord after transplantation of olfactory ensheathing cells into the region of posttraumatic cysts.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Voronova АD,Stepanova OV,Valikhov MP,Chadin AV,Semkina АS,Abakumov MA,Reshetov IV,Chekhonin VPdoi
10.1007/s10517-019-04568-zsubject
Has Abstractpub_date
2019-08-01 00:00:00pages
536-540issue
4eissn
0007-4888issn
1573-8221pii
10.1007/s10517-019-04568-zjournal_volume
167pub_type
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