Abstract:
:Differential expression of type 1 cannabinoid receptors (CR1) was evaluated at different stages of human skin fibroblast transformation into terminally differentiated neurons. Immunocytochemical staining detected no CR1 on fibroblasts, but their transformation into induced pluripotent stem cells was accompanied by marked stimulation of CR1 expression. In neuronal precursors, the receptors were located mainly on cell bodies and at the base of their processes. This distribution was retained at the terminal stage of differentiation of induced pluripotent stem cells into neurons.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Bobrov MY,Bezuglov VV,Khaspekov LG,Illarioshkin SN,Novosadova EV,Grivennikov IAdoi
10.1007/s10517-017-3782-2subject
Has Abstractpub_date
2017-06-01 00:00:00pages
272-275issue
2eissn
0007-4888issn
1573-8221pii
10.1007/s10517-017-3782-2journal_volume
163pub_type
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