Abstract：
:Leprosy was modeled in an experiment on BALB/c, BALB/cNude, CBA, and C57BL/6ТNF-/- mice using three Mycobacterium leprae strains obtained from patients with a diagnosis of A30 according to ICD-10 from different regions of the Russian Federation. Proliferation of M. leprae of the used strains showed a temporal-quantitative dependence on the used mouse line. CBA and BALB/cNude mice were optimal for strain R and BALB/c and BALB/cNude lines were optimal for strain I. BALB/cNude mice infected with strain I had low lifespan. M. leprae strain M showed low proliferation activity in BALB/cNude and C57BL/6ТNF-/- mice.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Karamova AE,Semenova VG,Verbenko DA,Obraztsova OA,Vanchugova KM,Nikonorov AA,Deryabin DG,Solomka VS,Kubanov AAdoi
10.1007/s10517-020-04991-7subject
Has Abstractpub_date
2020-10-01 00:00:00pages
836-839issue
6eissn
0007-4888issn
1573-8221pii
10.1007/s10517-020-04991-7journal_volume
169pub_type
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