Suppression of ITGB4 Gene Expression in PC-3 Cells with Short Interfering RNA Induces Changes in the Expression of β-Integrins Associated with RGD-Receptors.

abstract：:Levosimendan is effective in the therapy of chronic heart failure in both mature and old rats, but the duration of its therapeutic effect differs in these age groups. In 15 days after treatment, the myocardium in old rats maintained augmented functionality, whereas in old animals, functional potencies returned to the ...

journal_title：Bulletin of experimental biology and medicine

authors： Mamalyga ML,Mamalyga LM

更新日期：2020-05-01 00:00:00

abstract：:We studied the effects of ionophores on activity of Na+,Cl-(HCO 3- )-ATPase. The most significant effect on the activity of this enzyme was produced by protonophore 2,4-dinitrophenol. The effect of this drug largely depended on the cation and anion composition and pH of the incubation medium and its pH. Activity of Na...

journal_title：Bulletin of experimental biology and medicine

authors： Yurkiv VA,Melikhov VI,Shubin VS

更新日期：2016-10-01 00:00:00

abstract：:The location and level of IL-8 and TGF-beta2 expression in the fimbrial compartment of fallopian tubes and IL-10 expression in the endometrium of women with pyoinflammatory adnexal diseases were studied by in situ hybridization. These diseases are associated with considerable changes in the levels of local production ...

journal_title：Bulletin of experimental biology and medicine

authors： Zhdanov AV,Kurbanova DF,Sosulina LY,Davydova MP,Ezhova LS,Sukhikh GT

更新日期：2003-03-01 00:00:00

abstract：:The levels of himantane and its metabolites in daily urine and feces of rats were measured after intraperitoneal and oral dose of 25 mg/kg. The injected dose of the initial substance and 1.3% its metabolites were eliminated with excrements within 24 h after administration via both routes 0.23%. ...

journal_title：Bulletin of experimental biology and medicine

authors： Litvin EA,Bastrygin DV,Kolyvanov GB,Alekseyev KV,Zherdev VP

更新日期：2012-08-01 00:00:00

abstract：:The expression of synaptophysin (vesicular protein) and mGluR5 (metabotropic glutamate receptor) genes was studied 3, 7, and 20 days after cainic acid injury of the dorsal hippocampal area in Wistar rats. The expression of both genes was characteristically reduced in the hippocampus. Twenty days after the exposure the...

journal_title：Bulletin of experimental biology and medicine

authors： Lebedev DS,Arkhipov VI

更新日期：2009-02-01 00:00:00

abstract：:Characteristics of distribution of cholinergic and adrenoceptor structures along the sinoatrial node artery in rat heart were evaluated by autoradiography on semithin sections by determining the density of (3)H-dihydroalprenolol and (3)H-quinuclidinyl benzilate binding sites. The relative density of binding sites for ...

journal_title：Bulletin of experimental biology and medicine

authors： Sutyagin PV,Kalinina EE,Pylaev AS

更新日期：2005-07-01 00:00:00

abstract：:We studied the effect of ozonized physiological saline on phagocytic properties of polymorphonuclear neutrophilic leukocytes from dog blood. Intravenous infusion of the examined doses of ozonized saline stimulated phagocytosis. Repeated intravenous infusion (48 h after) of the same dose was followed by a significant d...

journal_title：Bulletin of experimental biology and medicine

authors： Volkhovskaya NB,Tkachenko SB,Belopolsky AA

更新日期：2008-11-01 00:00:00

abstract：:We studied the expression of genes encoding angiotensinogen (Agt), renin (Ren), angiotensin-converting enzyme (ACE), and type 1 angiotensin receptor (AT1A) in the hypothalamus and medulla oblongata of hypertensive ISIAH rats and normotensive WAG rats. The amount of Agt mRNA in the hypothalamus of young ISIAH rats was ...

journal_title：Bulletin of experimental biology and medicine

authors： Klimov LO,Fedoseeva LA,Ryazanova MA,Dymshits GM,Markel AL

更新日期：2013-01-01 00:00:00

abstract：:The influence of a new 2-mercaptobenzimidazole derivative afobazole on cytogenetic effects of dioxidine and cyclophosphamide was studied by counting chromosome aberrations in bone marrow cells of C57Bl/6 mice. Afobazole (1-100 mg/kg perorally) exhibited antimutagenic activity determined by its antioxidant properties. ...

journal_title：Bulletin of experimental biology and medicine

authors： Zhanataev AK,Durnev AD,Seredin SB

更新日期：2000-11-01 00:00:00

abstract：:Study of the epidermocyte nuclear-nucleolar system in atopic dermatitis and lichen planus by computer morphometry of preparations stained with 50% AgNO3 showed an increase in their morphometric parameters, reflecting hyperregeneratory processes. ...

journal_title：Bulletin of experimental biology and medicine

authors： Sapuntsova SG,Tsygankov VI,Simkatcheva MV,Timoshin SS

更新日期：2007-09-01 00:00:00

abstract：:We studied daily dynamics of proliferative activity of embryonic fibroblast-like cells in culture during the logarithmic growth phase. Daily increase in cell count in the culture showed a 4-day rhythm that persisted over 3 weeks of culturing. In cultures from different animals, the phase of this rhythm was synchronous...

journal_title：Bulletin of experimental biology and medicine

authors： Diatroptova MA,Ponomarenko EA,Diatroptov ME

更新日期：2020-09-01 00:00:00

abstract：:Plasma cytokine concentration in patients with Parkinson's disease and mutation in GBA gene, in patients with sporadic Parkinson's disease, and in healthy volunteers were measured by ELISA and multiplex analysis. In patients with Parkinson's disease and mutation in GBA gene, elevated plasma concentrations of IL-1β and...

journal_title：Bulletin of experimental biology and medicine

authors： Miliukhina IV,Usenko TS,Senkevich KA,Nikolaev MA,Timofeeva AA,Agapova EA,Semenov AV,Lubimova NE,Totolyan AA,Pchelina SN

更新日期：2020-02-01 00:00:00

abstract：:Lyzed epimastigotes of Trypanosoma cruzi clones P209-1, Gamba1, Sp104-1, MASu, Y7/1, MN12, Cl-Brener, 86/2036, Y7/2-1 inhibit the growth of Ehrlich adenocarcinoma in mice. the tumor decreased 1.5-3 times after 12 daily injections of lysates from 15 million epimastigotes. The protective effect progressed after the inje...

journal_title：Bulletin of experimental biology and medicine

authors： Batmonkh Z,Kallinikova VD,Pakhorukova LV,Kravtsov EG,Karpenko LP,Dalin MV

更新日期：2006-10-01 00:00:00

abstract：:We studied expression of malignancy markers galectin-3, cytokeratin-19, HBME-1, fibronectin, and cyclin D1 in cells of benign (n=51), malignant (n=87), and borderline (n=53) tumors. The results indicate that 3.9% benign and 41.5% borderline tumors express malignancy markers (specificity 98-100%). Follow up over 1-10 y...

journal_title：Bulletin of experimental biology and medicine

authors： Abrosimov AY,Dvinskikh NY,Sidorin AV

更新日期：2016-03-01 00:00:00

abstract：:Biopsy specimens from large bronchi of patients with central and peripheral pulmonary cancer were studied. Central cancer was associated with hyperplasia and dysplasia of the epithelium, hyperplasia of glandular compartment, and pronounced immunocompetent cell response. Peripheral cancer was characterized by predomina...

journal_title：Bulletin of experimental biology and medicine

authors： Nepomnyashchikh GI,Levitskii VA,Dolgovykh AK,Naumova LA

更新日期：2002-08-01 00:00:00

abstract：:Cytogenetic analysis of 13 mesenchymal stem cell cultures isolated from normal human adipose tissue was carried out at different stages of culturing. The incidence of chromosomes 6, 8, 11, and X aneuploidy and polyploidy was studied by fluorescent in situ hybridization. During the early passages, monosomal cells were ...

journal_title：Bulletin of experimental biology and medicine

authors： Buyanovskaya OA,Kuleshov NP,Nikitina VA,Voronina ES,Katosova LD,Bochkov NP

更新日期：2009-07-01 00:00:00

abstract：:The hydruric response to water load in Wistar rats and homozygous Brattleboro rats with a hereditary defect in the synthesis of vasopressin was studied under conditions of increased brain serotonin level. Serotonin prevented the reduction in reabsorption of osmotically free water in normal rats, but had no effect in v...

journal_title：Bulletin of experimental biology and medicine

authors： Ivanova LN,Kochkaeva LN,Melidi NN

更新日期：2006-02-01 00:00:00

abstract：:We performed immunohistochemical analysis of the expression of TGFβ, galectin-1, vimentin, and thrombospondin in the mucosa in gastric cancer of diffuse and intestinal type associated with systemic undifferentiated connective tissue dysplasia. In diffuse gastric cancer, both with and without association with connectiv...

journal_title：Bulletin of experimental biology and medicine

authors： Naumova LA,Osipova ON,Klinnikova MG

更新日期：2019-04-01 00:00:00

abstract：:The kinetics of thrombin inhibition by irons ions was studied in the thrombin time test with normal plasma. The kinetic and concentration characteristics for recovery of thrombin activity by desferal were evaluated at various periods of thrombin incubation with iron ions. The thrombin time test showed that incubation ...

journal_title：Bulletin of experimental biology and medicine

authors： Azizova OA,Shvachko AG,Aseichev AV

更新日期：2009-11-01 00:00:00

abstract：:The level of expression of CD11b and HLA-DR surface molecules on monocyte-like THP-1 cells increased significantly as a result of transmigration of these cells through a monolayer of endothelial cells. The expression of all studied markers (CD11b, HLA-DR, and CD-14) increased significantly after transendothelial migra...

journal_title：Bulletin of experimental biology and medicine

authors： Starikova EA,Sokolov DI,Chernova AA,Freidlin IS

更新日期：2008-11-01 00:00:00

abstract：:Leukocyte count decreased, relative content of neutrophils and monocytes increased, and their phagocytic activity was suppressed in rats with 1-methyl-4-phenyl-1,2,3,4-tetrahydropyridine-induced depressive syndrome at the stage of acute behavioral depression. The severity of behavioral depression inversely correlated ...

journal_title：Bulletin of experimental biology and medicine

authors： Krupina NA,Davydova TV,Fomina VG,Kryzhanovskii GN,Orlova IN

更新日期：2000-11-01 00:00:00

abstract：:Structure of arteries of different diameter in early and late periods of hypertension caused by experimental coarctation of the aorta was studied by histological and morphometric methods. Blood pressure was measured directly via catheterization of the common carotid artery and used for evaluation of hemodynamic in the...

journal_title：Bulletin of experimental biology and medicine

authors： Gansburgsky AN,Jaltsev AV

更新日期：2012-07-01 00:00:00

abstract：:We studied the effects of plant extracts and products of their biological treatment on trans-sialidase activity in human blood plasma. Extracts of kelp, fucus, yarrow, Saint John's wort, onion, and honey in vitro decreased trans-sialidase activity. Extracts of pollen (beebread) and garlic powder produced the maximum i...

journal_title：Bulletin of experimental biology and medicine

authors： Aksenov DV,Kaplun VV,Tertov VV,Sobenin IA,Orekhov AN

更新日期：2007-01-01 00:00:00

abstract：:Morphological study of allotransplants of rat embryonic neocortex 14-18 months after transplantation into the neocortex, lateral cerebral ventricle, and sciatic nerve of adult animals revealed death of nerve and glial cells in the delayed postoperation period independently on the site of transplantation. After heterot...

journal_title：Bulletin of experimental biology and medicine

authors： Petrova ES,Otellin VA

更新日期：2003-09-01 00:00:00

abstract：:Polymorphic variants of CYP1A2 and CYP2D6 genes of the cytochrome P450 system were studied in patients with schizophrenia with drug-induced motor disorders and hyperprolactinemia against the background of long-term neuroleptic therapy. We revealed an association of polymorphic variant C-163A CYP1A2*1F of CYP1A2 gene w...

journal_title：Bulletin of experimental biology and medicine

authors： Ivanova SA,Filipenko ML,Vyalova NM,Voronina EN,Pozhidaev IV,Osmanova DZ,Ivanov MV,Fedorenko OY,Semke AV,Bokhan NA

更新日期：2016-03-01 00:00:00

abstract：:The role of signaling molecules in synthesis of humoral regulators of granulocytopoiesis by the hematopoietic microenvironmental cells during stress was analyzed using specific inhibitors. The major role in stimulation of the synthesis of granulocytic CSF during stressful stimulation is played by PI3K/Akt signaling ca...

journal_title：Bulletin of experimental biology and medicine

authors： Zhdanov VV,Miroshnichenko LA,Udut EV,Polyakova TY,Zyuz'kov GN,Simanina EV,Sherstoboev EY,Stavrova LA,Agafonov VI,Minakova MY,Dygai AM

更新日期：2019-01-01 00:00:00

abstract：:Comparative analysis of the efficiency of PCR and microbiological methods for deciphering of the etiological structure of non-nosocomial pneumonias demonstrated the diagnostic significance of detecting Streptococcus pneumoniae DNA in the blood, but not sputum. Mechanisms of penetration of S. pneumoniae into the blood ...

journal_title：Bulletin of experimental biology and medicine

authors： Artemova LV,Beskhlebnaya VA,Ezhova LG,Kirillov MY,Kravtsov EG,Dalin MV

更新日期：2003-10-01 00:00:00

abstract：:More than 70% malignant mammary tumors contain steroid hormone receptors; this suggests the possibility of hormone therapy in the majority of patients with breast cancer (BC). The main cause of inefficiency of hormone therapy in BC is hormone resistance (tumor resistance to hormonal cytostatics). Here we discuss the m...

journal_title：Bulletin of experimental biology and medicine

authors： Scherbakov AM,Krasil'nikov MA,Kushlinskii NE

更新日期：2013-07-01 00:00:00

abstract：:Oxidative modification of fibrinogen in acute myocardial infarction increased 1.3-fold compared to that in CHD and 1.5-fold surpassed that in the control without CHD. Elevated content of oxidized fibrinogen correlated with increased levels of LPO products, von Willebrand factor, and fibrin degradation products, with a...

journal_title：Bulletin of experimental biology and medicine

authors： Ragino YI,Baum VA,Polonskaya YV,Sadovski EV,Baum SR,Nikitin YP

更新日期：2008-04-01 00:00:00

abstract：:The effects of glucocorticoids on monocyte morphology and function in vitro and the results of high-dose budesonide therapy in patients with non-severe bronchial asthma were analyzed. Before therapy with inhalation glucocorticosteroid (budesonide) characteristics of blood monocytes and the effects of different concent...

journal_title：Bulletin of experimental biology and medicine

authors： Terpigorev SA,Il'chenko VA,Vasilenko IA,Slinchenko OI,Stotskaya TV,Markina TR,Paleev NR

更新日期：2003-06-01 00:00:00