Abstract:
:Morphological study of allotransplants of rat embryonic neocortex 14-18 months after transplantation into the neocortex, lateral cerebral ventricle, and sciatic nerve of adult animals revealed death of nerve and glial cells in the delayed postoperation period independently on the site of transplantation. After heterotopic transplantation the count of degenerated neurons was 2 times higher that after homotopic transplantation. In heterotopic transplants a considerable number of grafted neurons underwent reversible and irreversible degenerative changes accompanied by their premature aging. Neuronal death is probably determined by insufficiency of trophic influence from afferent structures and target tissues. We hypothesized that antiapoptotic preparations can be used for prevention of transplanted cell death. It was also found that degeneration of neurons was associated with impaired vascularization of transplants and pronounced immune reaction of the recipient in late posttransplantation period. Transplantation of embryonic brain structures can serve as a model system in studies concerning involutive and pathological processes in the central nervous system and in the search for factors improving survival of neurons.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Petrova ES,Otellin VAdoi
10.1023/b:bebm.0000008989.24898.dfsubject
Has Abstractpub_date
2003-09-01 00:00:00pages
302-6issue
3eissn
0007-4888issn
1573-8221journal_volume
136pub_type
杂志文章abstract::Administration of granulocyte CSF preparation to patients with chronic heart failure produced a hemostimulating effect and increased the content of leukocytes and neutrophils in the peripheral blood. Granulocyte CSF induced mobilization of bone marrow progenitor cells into the peripheral blood. The content of hemopoie...
journal_title:Bulletin of experimental biology and medicine
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journal_title:Bulletin of experimental biology and medicine
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