Abstract:
:We studied the effects of dipeptidyl peptidase 4 (DPP4) inhibitor linagliptin on the expression of apoptosis regulator proteins Bcl-2 and Bad in the liver of db/db mice with genetically determined obesity and type 2 diabetes mellitus. The mice received daily linagliptin or saline (placebo) by gavage from week 10 to week 18 of life. In the liver of non-treated mice, the area positively stained for Bad was greater than the area of Bcl-2 expression, which created the conditions for apoptosis activation in liver at this age. Administration of linagliptin decreased Bad stained area and increased Bcl-2 stained area in the liver cells. At the same time, Bad stained area remained larger in treated mice than the area of Bcl-2 expression area, which attested to partial normalization of pro- and antiapoptotic protein balance.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Michurina SV,Cherepanova MA,Ishchenko IY,Arkhipov SA,Klimontov VV,Zav'yalov ELdoi
10.1007/s10517-019-04493-1subject
Has Abstractpub_date
2019-06-01 00:00:00pages
210-214issue
2eissn
0007-4888issn
1573-8221pii
10.1007/s10517-019-04493-1journal_volume
167pub_type
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