Abstract:
:Anticonvulsant activity and pharmacokinetics of nanoemulsion and unmodified substance of carbamazepine were compared in experiments on mice. Carbamazepine nanoemulsion demonstrated significant anticonvulsant activity and was superior to unmodified substance of carbamazepine against seizures induced by maximum electric shock and picrotoxin. Relative bioavailability of carbamazepine after administration of nanoemulsion was 160% compared to unmodified substance. Carbamazepine nanoemulsion more effectively penetrated through BBB by 1.5 times in comparison with unmodified substance.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Prokhorov DI,Sariev AK,Abramov DA,Voronina TA,Kapitsa IG,Zhuravko AS,Shiriaeva MV,Kaplun AP,Seifulla RDdoi
10.1007/s10517-014-2657-zsubject
Has Abstractpub_date
2014-10-01 00:00:00pages
742-6issue
6eissn
0007-4888issn
1573-8221journal_volume
157pub_type
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