Abstract：
:Polymorphic variants of CYP1A2 and CYP2D6 genes of the cytochrome P450 system were studied in patients with schizophrenia with drug-induced motor disorders and hyperprolactinemia against the background of long-term neuroleptic therapy. We revealed an association of polymorphic variant C-163A CYP1A2*1F of CYP1A2 gene with tardive dyskinesia and association of polymorphic variant 1846G>A CY2D6*4 and genotype A/A of CYP2D6 gene (responsible for debrisoquin-4-hydroxylase synthesis) with limbotruncal tardive dyskinesia in patients with schizophrenia receiving neuroleptics for a long time.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Ivanova SA,Filipenko ML,Vyalova NM,Voronina EN,Pozhidaev IV,Osmanova DZ,Ivanov MV,Fedorenko OY,Semke AV,Bokhan NAdoi
10.1007/s10517-016-3250-4subject
Has Abstractpub_date
2016-03-01 00:00:00pages
687-90issue
5eissn
0007-4888issn
1573-8221pii
10.1007/s10517-016-3250-4journal_volume
160pub_type
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