Abstract:
:The dose-dependent effect of intranasal administration of antibodies to glutamate on acute generalized epileptic activity was studied in C57Bl/6 mice. It was shown that pretreatment with antibodies in doses of 100, 300, and 500 μg/kg 1 h before titration with convulsant pentylenetetrazole had anticonvulsant effects. This treatment was followed by an increase in the thresholds of clonic and tonic seizures with fatal outcome and lengthening of seizure latency. The most pronounced effect was observed in doses of 300 and 500 μg/kg. Comparison of the anticonvulsant effect of antibodies in active immunization with glutamate-BSA conjugate and systemic intraperitoneal administration of purified anti-glutamate antibodies revealed advantages of intranasal administration.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Karpova MN,Kuznetsova LV,Vetrile LA,Klishina NJdoi
10.1007/s10517-013-2140-2subject
Has Abstractpub_date
2013-07-01 00:00:00pages
309-11issue
3eissn
0007-4888issn
1573-8221journal_volume
155pub_type
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