Hydruric response in Wistar and vasopressin-deficient Brattleboro rats to water load under conditions of increased brain serotonin level.

Abstract:

:The hydruric response to water load in Wistar rats and homozygous Brattleboro rats with a hereditary defect in the synthesis of vasopressin was studied under conditions of increased brain serotonin level. Serotonin prevented the reduction in reabsorption of osmotically free water in normal rats, but had no effect in vasopressin-deficient Brattleboro rats. Our results suggest that serotonin stimulates vasopressin secretion and interacts with the vasopressinergic system during the realization of osmotic regulation.

journal_name

Bull Exp Biol Med

authors

Ivanova LN,Kochkaeva LN,Melidi NN

doi

10.1007/s10517-006-0121-4

subject

Has Abstract

pub_date

2006-02-01 00:00:00

pages

178-80

issue

2

eissn

0007-4888

issn

1573-8221

journal_volume

141

pub_type

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