Survival of rats with experimental chronic heart failure depending on pharmacodynamic and pharmacokinetic parameters of angiotensin-converting enzyme inhibitors and beta-adrenoceptor blockers.

Abstract:

:Lipophilic inhibitors of angiotensin-converting enzyme increased 6-month survival and/or lifetime of rats with experimental chronic heart failure. These drugs had no effect on the mortality rate of animals with acute decompensation of the disease. beta-Adrenoceptor blockers without intrinsic sympathomimetic activity not only prolonged 6-month survival and lifetime, but also decreased the mortality rate of rats with decompensation of chronic heart failure.

journal_name

Bull Exp Biol Med

authors

Fedorov VN,Sal'nikov EV,Sidorov AV,Bogatushin AV,Fateev MM

doi

10.1007/s10517-006-0088-1

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

40-3

issue

1

eissn

0007-4888

issn

1573-8221

journal_volume

141

pub_type

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